Results 71 to 80 of about 93,718 (253)

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis

ChemistryOpen, EarlyView.
The study demonstrated that thidiazine compounds potentiated the action of antibiotics. The compounds associated with norfloxacin against S. aureus showed greater significance in relation to the other medications. The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of ...
João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Radosław Kowalski, Grażyna Kowalska, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Ana Carolina Justino de Araújo   +15 more
wiley   +1 more source

Otitis in pet guinea pigs: Causes, clinical signs, treatment and outcomes

Veterinary Record, EarlyView.
Abstract Background Otitis is a major disease impacting both pet guinea pigs and laboratory guinea pigs that are used as models in human otological studies. Methods Medical records from two veterinary clinics were retrospectively reviewed to identify guinea pigs diagnosed with computed tomography (CT)‐confirmed otitis between 2014 and 2023.
Patricia Muffat‐es‐Jacques, Mathilde Charrasse, Paul Raymond, Minh Huynh, Thomas Coutant, Charly Pignon   +5 more
wiley   +1 more source

Recent Advances in Optical Detection of Aminoglycosides

Applied Sciences, 2020
Aminoglycosides (AGs) are broad-spectrum antibiotics used in both human infection and animal medicine. The overuse of AGs causes undesirable residues in food, leading to serious health problems due to food chain accumulation.
Yan Zhou, Yanwei Ji, Zhijuan Cao
doaj   +1 more source

Designer Aminoglycosides That Selectively Inhibit Cytoplasmic Rather than Mitochondrial Ribosomes Show Decreased Ototoxicity

Journal of Biological Chemistry, 2013
Background: Whether the mitochondrial or cytoplasmic protein synthesis inhibition predominates to aminoglycoside-induced ototoxicity is unclear. Results: The ototoxicity of an aminoglycoside correlates primarily with its ability to block mitochondrial ...
E. Shulman, V. Belakhov, G. Wei, A. Kendall, E. Meyron-Holtz, D. Ben-Shachar, J. Schacht, T. Baasov   +7 more
semanticscholar   +1 more source

A structured, behavioural science approach to the preparation of antimicrobial stewardship interventions for companion animal veterinarians

Veterinary Record, EarlyView.
Abstract Background A structured, behavioural science approach was adopted to develop antimicrobial stewardship interventions in UK first‐opinion companion animal veterinary practice. The objectives were to identify behavioural targets for intervention and to understand how practice contexts influence these behaviours.
Ben Walker, Dan O'Neill, Huw Stacey, Dave Brodbelt   +3 more
wiley   +1 more source

The impact of aminoglycosides on the dynamics of translation elongation.

Cell Reports, 2013
Inferring antibiotic mechanisms on translation through static structures has been challenging, as biological systems are highly dynamic. Dynamic single-molecule methods are also limited to few simultaneously measurable parameters.
Albert Tsai, S. Uemura, Magnus Johansson, Magnus Johansson, E. V. Puglisi, R. Marshall, R. Marshall, Colin Echeverría Aitken, Colin Echeverría Aitken, J. Korlach, M. Ehrenberg, J. Puglisi   +11 more
semanticscholar   +1 more source

Belgian bovine veterinarian practices and opinions on udder health‐related antimicrobial use and services

Veterinary Record, EarlyView.
Abstract Background Changing legislation regarding antimicrobial consumption (AMC) forces Flemish bovine veterinary practitioners (BVP) to rethink their business models and shift their on‐farm practices from curative to preventive. However, little is known about their current practices and opinions regarding antibiotic stewardship, mastitis treatment ...
Lien Creytens, Sofie Piepers, Sarne De Vliegher   +2 more
wiley   +1 more source

Clinical Features and Outcomes of Chronic Otitis Media Complications: A 20‐Year Retrospective Study at a Tertiary Hospital

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Chronic otitis media (COM) is a major public health concern, particularly in developing countries. Although complications have decreased with modern antibiotics, they still cause significant morbidity and mortality. This study analyzed the clinical features, bacteriological profiles, and treatment outcomes of COM complications at a ...
Viraporn Atchariyasathian, Nipit Tangchitnob   +1 more
wiley   +1 more source

Overexpression of Escherichia coli yaiX Confers Multidrug Resistance and Enhances Virulence in the Silkworm Infection Model

Microbiology and Immunology, EarlyView.
ABSTRACT The emergence of bacteria with both antimicrobial resistance and high virulence has become a global health concern, underscoring the urgent need to elucidate the molecular basis underlying these traits. Here, we employed the silkworm (Bombyx mori) infection model, which is suitable for high‐throughput screening, together with an Escherichia ...
Kinuka Hongu, Kazuya Ishikawa, Tomoki Kosaki, Shin‐Ichi Miyoshi, Kazuyuki Furuta, Chikara Kaito   +5 more
wiley   +1 more source

Genetic engineering for SIT application: a fruit fly‐focused review

Insect Science, EarlyView.
Abstract Sterile insect technique (SIT) has become a key component of efficient pest control. Fruit fly pests from the Drosophilidae and Tephritidae families pose a substantial and overwhelmingly increasing threat to the agricultural industry, aggravated by climate change and globalization among other contributors.
Serafima Davydova, Danheng Yu, Angela Meccariello   +2 more
wiley   +1 more source