Results 51 to 60 of about 56,556 (236)

Synergistic Effect and Mechanism of Plumbagin with Gentamicin Against Carbapenem-Resistant Klebsiella pneumoniae

Infection and Drug Resistance, 2020
Xiuli Chen,* Liyuan Yin,* Linxiu Peng, Yanshan Liang, Hang Lv, Tonghui Ma School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, People’s Republic of China*These authors contributed equally to this ...
Chen X, Yin L, Peng L, Liang Y, Lv H, Ma T   +5 more
doaj  

Impact of cumulative glucocorticoid exposure on vancomycin clearance in hospitalized children: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Prior glucocorticoid exposure is associated with modestly increased vancomycin clearance in hospitalized children, partly mediated by renal function and inflammation and may contribute to subtherapeutic early drug exposure. Abstract Introduction Augmented renal clearance (ARC) can lead to subtherapeutic vancomycin exposure in children.
Kouki Tomari, Ruud H. J. Verstegen, Cintia Cruz, Erin Chung, Aleena Azim, Shinya Ito, Tamorah R. Lewis   +6 more
wiley   +1 more source

Cyclic Peptide MV6, an Aminoglycoside Efficacy Enhancer Against Acinetobacter baumannii

Antibiotics
Background/Objectives: Acinetobacter baumannii is a globally emerging pathogen with widespread antimicrobial resistance driven by multiple mechanisms, such as altered expression of efflux pumps like AdeABC, placing it as a priority for research.
Natalia Roson-Calero, Jimmy Lucas, María A. Gomis-Font, Roger de Pedro-Jové, Antonio Oliver, Clara Ballesté-Delpierre, Jordi Vila   +6 more
doaj   +1 more source

MT‐RNR1 genotype testing for preventing aminoglycoside‐mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Aminoglycosides are broad‐spectrum antibiotics used in the management of severe infections. Aminoglycosides are associated with nephrotoxicity and ototoxicity. Although dosing strategies such as once‐daily administration and therapeutic drug monitoring have reduced the incidence of nephrotoxicity, ototoxicity remains unpredictable and may occur at ...
John H. McDermott, Sian Hilton, Cinzia Dello Russo, Nicola Booth, Simon Drysdale, Philip Howard, Stephen Hughes, Mallinath Chakraborty, Helen McDevitt, Charlotte Alston, Maya Desai, Mike Beadsworth, Adam Reynolds, Serim Min, Katherine Payne, Munir Pirmohamed, William G. Newman   +16 more
wiley   +1 more source

Aminoglycoside heteroresistance in Enterobacter cloacae is driven by the cell envelope stress response

mBio
Enterobacter cloacae is a Gram-negative nosocomial pathogen of the ESKAPE (Enterococcus, Staphylococcus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.) priority group with increasing multi-drug resistance via the acquisition of resistance
Ana J. Choi, Daniel J. Bennison, Esha Kulkarni, Hibah Azar, Haoyu Sun, Hanqi Li, Jonathan Bradshaw, Hui Wen Yeap, Nicholas Lim, Vishwas Mishra, Anna Crespo-Puig, Ewurabena A. Mills, Frances Davies, Shiranee Sriskandan, Avinash R. Shenoy   +14 more
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

H-NS controls the susceptibility of Escherichia coli to aminoglycosides by interfering its uptake and efflux

Frontiers in Veterinary Science
H-NS is a histone-like nucleoid-structuring protein that regulates gene expressions, particularly acquired foreign genes, however, little is known about whether H-NS can modulate bacterial susceptibility by regulating its intrinsic genes. The hns-deleted
Qiuru Chen, Yulei Liang, Yanbin Dong, Junling Cui, Kun He, Xiaoyuan Ma, Jinfeng Zhao, Jinfeng Zhao, Yajun Zhai, Yajun Zhai, Li Yuan, Li Yuan, Li Yuan, Li Yuan   +13 more
doaj   +1 more source

Highly Potent Fluorogenic Ligands for Triplex DNA: 5‐Substituted 2‐(Naphthalen‐2‐yl)‐4H‐Chromen‐4‐Ones

Chemistry – A European Journal, EarlyView.
5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran, Landy Gu, Krege M. Christison, Kalee Thao, Liang Xue   +4 more
wiley   +1 more source

Surface‐Strongly Complexed BiVO4 Homojunction Photoanodes: Enabling Efficient Antibiotic Pollutant Degradation and Resource Upgrading

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Herein, a synergistic photoelectrochemical‐photothermal platform is constructed for simultaneous kanamycin remediation and resource valorization, addressing energy and environmental concerns. Photoelectrochemical (PEC) technology offers a promising approach for degrading antibiotic pollutants, yet it remains constrained by low efficiency and incomplete
Zhaoqi Wang, Yaqi He, Xiaolei Liu, Zaizhu Lou, Difei Xiao, Peng Wang, Zhaoke Zheng, Yuanyuan Liu, Hefeng Cheng, Baibiao Huang, Zeyan Wang, Dongqi Tang   +11 more
wiley   +1 more source

Implantable electrochemical sensors for continuous blood monitoring

FlexMat, EarlyView.
Implantable electrochemical sensors enable direct, in situ, and continuous blood monitoring, shifting diagnosis from population‐based averages to dynamic, individualized analysis. This review systematically examines the influence of the unique blood properties on sensor design.
Kuangyi Zou, Yuanzhen Wang, Haidong Wang, Ye Zhang   +3 more
wiley   +1 more source