Results 51 to 60 of about 69,960 (284)
Once-daily aminoglycosides: practical guidelines
, 1998 There is ample evidence that once-daily dosing of aminoglycosides is preferable to the conventional regimens during the treatment of serious infections.
Prins, J. M., Speelman, P.
core +1 more source
Biosynthetic pathways of aminoglycosides and their engineering
, 2021 Despite decades long clinical usage, aminoglycosides still remain a valuable pharmaceutical source for fighting Gram-negative bacterial pathogens, and their newly identified bioactivities are also renewing interest in this old class of antibiotics.
남상집 +3 more
core +1 more source
Precision medicine in paediatrics: Progress and priorities
British Journal of Clinical Pharmacology, EarlyView.Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain +3 more
wiley +1 more source
Therapeutic drug monitoring of aminoglycosides in neonates
, 2009 The efficacy and toxicity of aminoglycosides show a strong direct positive relationship with blood drug concentrations, therefore, therapy with aminoglycosides in adults is usually guided by therapeutic drug monitoring.
Sprij, Arwen J +2 more
core +2 more sources
Antibiotics, 2019 Orbignya speciosa (babassu) is an important palm tree in Brazil whose fixed almond oil is used in popular medicine and especially in food, in addition to being a research target for the manufacture of biofuels.
Jean Ferreira Machado +8 more
doaj +1 more source
Gentamicin in neonates with hemodynamically significant patent ductus arteriosus
Journal of Pharmacy and Bioallied Sciences, 2023 Background: Gentamicin has been shown to cause vasodilation in preclinical studies. Hemodynamically significant patent ductus arteriosus (hsPDA) is a commonly observed congenital heart disorder in preterm neonates.
Kannan Sridharan +6 more
doaj +1 more source
One Model to Dose Them All: A Population Pharmacokinetic Model for Multiple Aminoglycosides Across the Human Lifespan. [PDF]
J Clin PharmacolAbstract Aminoglycosides require therapeutic drug monitoring due to substantial pharmacokinetic variability across individuals. While population pharmacokinetic (popPK) models have been developed for individual drugs across age groups, and cross‐drug maturation models have been explored, it is unclear whether pooling data across aminoglycosides ...
Tong DMH +3 more
europepmc +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Prior glucocorticoid exposure is associated with modestly increased vancomycin clearance in hospitalized children, partly mediated by renal function and inflammation and may contribute to subtherapeutic early drug exposure. Abstract Introduction Augmented renal clearance (ARC) can lead to subtherapeutic vancomycin exposure in children.
Kouki Tomari +6 more
wiley +1 more source
Molecules, 2019 Glycosidic (β-1′′→6, 3′ and 4′) site isomers of neomycin B (i.e., neobiosamine (β-1′′→6, 3′ and 4′) neamines) have been synthesized in a straightforward manner.
Lotta Granqvist +2 more
doaj +1 more source
Antibiotics, 2020 The increasing prevalence of antimicrobial resistance and the laborious development of novel antimicrobial agents have limited the options for effective antimicrobial therapy.
Shukho Kim +5 more
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