Results 41 to 50 of about 71,389 (251)
Synthesis of 6″-Modified Kanamycin A Derivatives and Evaluation of Their Antibacterial Properties
Pharmaceutics, 2023 Aminoglycosides are one of the first classes of antibiotics to have been used clinically, and they are still being used today. They have a broad spectrum of antimicrobial activity, making them effective against many different types of bacteria.
Kseniya Shapovalova +6 more
doaj +1 more source
Aminoglycosides for the Treatment of Severe Infection Due to Resistant Gram-Negative Pathogens
, 2023 Aminoglycosides are a family of rapidly bactericidal antibiotics that often remain active against resistant Gram-negative bacterial infections. Over the past decade, their use in critically ill patients has been refined; however, due to their renal and ...
Jean-François Timsit +2 more
core +1 more source
Designer aminoglycosides prevent cochlear hair cell loss and hearing loss. [PDF]
, 2015 Bacterial infections represent a rapidly growing challenge to human health. Aminoglycosides are widely used broad-spectrum antibiotics, but they inflict permanent hearing loss in up to ~50% of patients by causing selective sensory hair cell loss.
Alan G. Cheng +21 more
core +2 more sources
Phytochemical analysis and modulation in aminoglycosides antibiotics activity by Lantana camara L.
Acta Scientiarum: Biological Sciences, 2015 Several plants have been evaluated not only for alone antimicrobial activity, but as resistance-modifying agent. This work is the first on the modulation of antibiotic activity by Lantana camara L.
Erlânio Oliveira de Sousa +3 more
doaj +1 more source
Electrostatic Interactions in RNA Aminoglycosides Binding
, 2016 Electrostatic Interactions in RNA Aminoglycosides ...
Hai Wang (310051), Yitzhak Tor (1339890)
core +1 more source
Advanced Science, EarlyView.Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green +15 more
wiley +1 more source
AntibioticsBackground/Objetives: Antimicrobial Resistance (AMR) is a multifaceted issue that the World Health Organization (WHO) identifies as one of the primary threats to global health for humans, animals, and the environment.
Aura Falco +5 more
doaj +1 more source
Frontiers in Oncology, 2018 The tumor suppressor gene TP53 is inactivated by mutation in a large fraction of human tumors. Around 10% of TP53 mutations are nonsense mutations that lead to premature termination of translation and expression of truncated unstable and non-functional ...
Meiqiongzi Zhang +5 more
doaj +1 more source
Structures of aminoglycosides kanamycin B and FG08.
, 2013 Structures of aminoglycosides kanamycin B and FG08.
Jon Y. Takemoto (456553) +4 more
core +1 more source
TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss
Advanced Science, EarlyView.TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale +23 more
wiley +1 more source