Results 31 to 40 of about 69,960 (284)
Kidney International, 1980 Nephrotoxicity has been recognized as a major complication of aminoglycoside antibiotics for many years. During the past 6 to 8 years, this problem has attracted the attention and interest of a number of investigators, resulting in the generation of a large body of experimental data that has greatly expanded our understanding of the pathogenesis of ...
Kaloyanides, George J. +1 more
openaire +2 more sources
Brazilian Journal of Otorhinolaryngology, 2010 O processo de morte e danos em células ciliadas devido à exposição ao ruído e ototoxinas parece ser mediado por espécies reativas de oxigênio. OBJETIVO: Investigar a relação entre polimorfismos gênicos na Glutationa S-transferase e a susceptibilidade à ...
Bruna Palodetto +4 more
doaj +1 more source
Frontiers in Microbiology, 2022 Aminoglycosides are not only antibiotics but also have wider and diverse non-antibiotic cellular functions. To elucidate the understanding of non-antibiotic cellular functions, here we report transcriptome-profiling analysis of Escherichia coli in the ...
Yaowen Chang +3 more
doaj +1 more source
Aminoglycosides ototoxicity molecular mechanisms [PDF]
, 2020 Aminoglycosides are a group of antibiotics which are currently widespread in clinical practice due to their relatively low price. However, aminoglycosides have several side effects that complicate their application.
Izmozherova, N. V. +11 more
core
MT-RNR1 genotype testing for preventing aminoglycoside-mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx). [PDF]
Br J Clin PharmacolAminoglycosides are broad‐spectrum antibiotics used in the management of severe infections. Aminoglycosides are associated with nephrotoxicity and ototoxicity. Although dosing strategies such as once‐daily administration and therapeutic drug monitoring have reduced the incidence of nephrotoxicity, ototoxicity remains unpredictable and may occur at ...
McDermott JH +16 more
europepmc +2 more sources
Pharmaceutics, 2021 The eradication of Pseudomonas aeruginosa in cystic fibrosis patients has become continuously difficult due to its increased resistance to treatments.
Douweh Leyla Gbian, Abdelwahab Omri
doaj +1 more source
Journal of Nepal Medical AssociationIntroduction: Urinary tract infections are the most common infections encountered in clinical practice. Treatment needs to take into account the likely organism, comorbidities and local antibiotic sensitivity pattern.
Bishnu Jwarchan +3 more
doaj +1 more source
Synthesis of 6″-Modified Kanamycin A Derivatives and Evaluation of Their Antibacterial Properties
Pharmaceutics, 2023 Aminoglycosides are one of the first classes of antibiotics to have been used clinically, and they are still being used today. They have a broad spectrum of antimicrobial activity, making them effective against many different types of bacteria.
Kseniya Shapovalova +6 more
doaj +1 more source
Late-stage functionalization of glucosides and aminoglycosides to combat resistant pathogens [PDF]
, 2022 The rapid emergence of resistant bacteria and the scarcity of antibiotic pipeline has been a persistent threat to the global health. To expand the antibiotic pipeline, we have focused our strategy by revitalizing the current antibiotic via novel site ...
xiaolei, wang +7 more
core +2 more sources
Phytochemical analysis and modulation in aminoglycosides antibiotics activity by Lantana camara L.
Acta Scientiarum: Biological Sciences, 2015 Several plants have been evaluated not only for alone antimicrobial activity, but as resistance-modifying agent. This work is the first on the modulation of antibiotic activity by Lantana camara L.
Erlânio Oliveira de Sousa +3 more
doaj +1 more source