Results 31 to 40 of about 71,389 (251)

Integrated Microfluidic Devices Fabricated in Poly (Methyl Methacrylate) (PMMA) for On-site Therapeutic Drug Monitoring of Aminoglycosides in Whole Blood

Biosensors, 2019
On-site therapeutic drug monitoring (TDM) is important for providing a quick and accurate dosing to patients in order to improve efficacy and minimize toxicity.
Zaidon T. Al-aqbi, Yiing C. Yap, Feng Li, Michael C. Breadmore   +3 more
doaj   +1 more source

Antimicrobial Synergy between Aminoglycosides and Licorice Extract in Listeria monocytogenes

Pathogens, 2022
Listeria monocytogenes is a foodborne pathogen that can develop serious invasive infections. Among foodborne pathogens, L. monocytogenes exhibits the highest case fatality despite antibiotic treatment, suggesting the current therapy should be improved ...
Myungseo Park, Liz Horn, Victoria Lappi, Dave Boxrud, Craig Hedberg, Byeonghwa Jeon   +5 more
doaj   +1 more source

Bioenergetic State of Escherichia coli Controls Aminoglycoside Susceptibility

mBio, 2023
Aminoglycosides (AG) have been used against Gram-negative bacteria for decades. Yet, how bacterial metabolism and environmental conditions modify AG toxicity is poorly understood.
Jessica Y. El Khoury, Jordi Zamarreño Beas, Allison Huguenot, Béatrice Py, Frédéric Barras   +4 more
doaj   +1 more source

KI04 an Aminoglycosides-Derived Molecule Acts as an Inhibitor of Human Connexin46 Hemichannels Expressed in HeLa Cells

Biomolecules, 2023
Background: Connexins (Cxs) are proteins that help cells to communicate with the extracellular media and with the cytoplasm of neighboring cells. Despite their importance in several human physiological and pathological conditions, their pharmacology is ...
Cheng-Wei T. Chang, Naveena Poudyal, Daniel A. Verdugo, Francisca Peña, Jimmy Stehberg, Mauricio A. Retamal   +5 more
doaj   +1 more source

Influência dos polimorfismos da glutationa s-transferase na ototoxicidade dos aminoglicosídeos Influence of glutathione s-transferase on the ototoxicity caused by aminoglycosides

Brazilian Journal of Otorhinolaryngology, 2010
O processo de morte e danos em células ciliadas devido à exposição ao ruído e ototoxinas parece ser mediado por espécies reativas de oxigênio. OBJETIVO: Investigar a relação entre polimorfismos gênicos na Glutationa S-transferase e a susceptibilidade à ...
Bruna Palodetto, Mariana Postal, Carlos Roberto Escrivão Grignoli, Edi Lúcia Sartorato, Camila Andréa de Oliveira   +4 more
doaj   +1 more source

Transcriptome profiling in response to Kanamycin B reveals its wider non-antibiotic cellular function in Escherichia coli

Frontiers in Microbiology, 2022
Aminoglycosides are not only antibiotics but also have wider and diverse non-antibiotic cellular functions. To elucidate the understanding of non-antibiotic cellular functions, here we report transcriptome-profiling analysis of Escherichia coli in the ...
Yaowen Chang, Xuhui Zhang, Alastair I. H. Murchie, Dongrong Chen   +3 more
doaj   +1 more source

Clinical pharmacokinetics of aminoglycosides in the neonate: a review [PDF]

, 2008
Sepsis is common in neonates and is a major cause of morbidity and mortality. Sixty percent of preterm neonates receive at least one antibiotic, and 43% of the antibiotics administered to these neonates are aminoglycosides. The clearance (Cl), serum half-
PACIFICI, GIAN MARIA
core   +1 more source

Aminoglycosides ototoxicity molecular mechanisms [PDF]

, 2020
Aminoglycosides are a group of antibiotics which are currently widespread in clinical practice due to their relatively low price. However, aminoglycosides have several side effects that complicate their application.
Izmozherova, N. V., Казанцев, Ю. А., Бахтин, В. М., Мельникова, В. В., Kashapova, E. F., Кашапова, Е. Ф., Koroleva, M. V., Melnikova, V. V., Bakhtin, V. M., Королева, М. В., Изможерова, Н. В., Kazancev, J. A.   +11 more
core  

The Impact of an Efflux Pump Inhibitor on the Activity of Free and Liposomal Antibiotics against Pseudomonas aeruginosa

Pharmaceutics, 2021
The eradication of Pseudomonas aeruginosa in cystic fibrosis patients has become continuously difficult due to its increased resistance to treatments.
Douweh Leyla Gbian, Abdelwahab Omri
doaj   +1 more source

Positive Bacterial Culture among Adults with Suspected Urinary Tract Infections Presenting to the Department of Medicine of a Tertiary Care Centre

Journal of Nepal Medical Association
Introduction: Urinary tract infections are the most common infections encountered in clinical practice. Treatment needs to take into account the likely organism, comorbidities and local antibiotic sensitivity pattern.
Bishnu Jwarchan, Subash Sapkota, Durga Dhungana, Anil Dhakal   +3 more
doaj   +1 more source