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Promising Approaches to Optimize the Biological Properties of the Antimicrobial Peptide Esculentin-1a(1–21)NH2: Amino Acids Substitution and Conjugation to Nanoparticles [PDF]

Frontiers in Chemistry, 2017
Antimicrobial peptides (AMPs) represent an interesting class of molecules with expanding biological properties which make them a viable alternative for the development of future antibiotic drugs.
Bruno Casciaro +3 more
doaj +4 more sources

Quantum chemical study of molecular properties of small branched-chain amino acids in water [PDF]

Amino Acids
Four aliphatic amino acids—α-aminobutyric acid (AABA), β-aminobutyric acid (BABA), α-aminoisobutyric acid (AAIBA) and β-aminoisobutyric acid (BAIBA) were investigated in water as a solvent by two quantum chemical methods.
Roman Boča +4 more
doaj +2 more sources

A Journey into the Blue: Current Knowledge and Emerging Insights into Marine-Derived Peptaibols [PDF]

Marine Drugs
Peptaibols represent a large family of membrane-active, linear fungal peptides, with variable lengths from 5 to 21 α–amino acid residues. As products of nonribosomal peptide synthetase (NRPS) biosynthetic machinery, they encompass several non ...
Claudia Finamore +4 more
doaj +2 more sources

Chemoenzymatic synthesis of polypeptides containing the unnatural amino acid 2-aminoisobutyric acid

Chemical Communications, 2017
Polypeptides containing 2-aminoisobutiryc acid (Aib) as an unnatural amino acid were synthesized via chemoenzymatic polymerization of the tripeptide ethyl ester AlaAibAla-OEt.
Kousuke, Tsuchiya, Keiji, Numata
openaire +4 more sources

Pertussis toxin nullifies the depolarisation of the membrane potential and the stimulation of the rapid phase of 45Ca2+ entry through L-type calcium channels that are produced by follicle stimulating hormone in 10- to 12-day-old-rat Sertoli cells. [PDF]

Frontiers in Physiology, 2010
The aim of this study was to evaluate the effect of pertussis toxin (PTX) on the depolarising component of the action of FSH on the membrane potential of Sertoli cells, which is linked to the rapid entry of Ca2+ into cells and to the Ca2+-dependent ...
Ana P Jacobus +3 more
doaj +3 more sources

Identification of blood biomarkers associated with hepatic lipid accumulation in aging laying hens with fatty liver [PDF]

Poultry Science
Fatty Liver Hemorrhagic Syndrome (FLHS) is a metabolic disorder characterized by excessive hepatic triglycerides (TG) accumulation, primarily affecting high-producing, caged laying hens.
Zheng Wang +5 more
doaj +2 more sources

Effect of Introducing Leucine Residues into 2‑Aminoisobutyric Acid-Based Amphiphilic Helical Peptides on Intermolecular Interactions and Peptide Self-Assembly. [PDF]