Results 21 to 30 of about 3,558 (167)

Toxicity and protein composition of venoms of Hottentotta saulcyi, Hottentotta schach and Androctonus crassicauda, three scorpion species collected in Iran

Veterinary Medicine and Science, 2021
Background Scorpion stings comprise a serious problem throughout the globe, especially in regions where they are more frequent. Despite a recent upsurge of interest in scorpion venoms by various research groups, there remain many challenges.
Ani Boghozian, Habibollah Nazem, Mohammad Fazilati, Seyed Hossein Hejazi, Mohammadreza Sheikh Sajjadieh   +4 more
doaj   +1 more source

Effects of water deficit during maturation on amino acids and jujube fruit eating quality

Macedonian Journal of Chemistry and Chemical Engineering, 2014
Pear-jujube yield and fruit characteristics can be clearly modified   by a water deficit imposed during fruit maturation period. One essential (cystine (Cys-cys)) and seven non-essential (4-hydroxyproline (p-Hyp), α-aminoadipic acid (AADA), ornithine ...
Jacinta Collado-González, Zulma N. Cruz, Sonia Medina, Carmen Mellisho, Pedro Rodríguez, Alejandro Galindo, Isabel Egea, Félix Romojaro, Federico Ferreres, Arturo Torrecillas, Angel Gil-Izquierdo   +10 more
doaj   +1 more source

Large‐Diameter DNA‐Scaffolded Nanopores Enabled by Loosely Packed Peptides for Single‐Molecule Sensing

Angewandte Chemie, EarlyView.
A nanopore composed of transmembrane peptides and a DNA scaffold that assists peptide assembly was constructed. By employing peptides containing the unnatural amino acid 2‐aminoisobutyric acid (Aib), which promotes loose packing between helices, a large‐diameter nanopore was achieved.
Zugui Peng, Daisuke Noshiro, Shiroh Futaki, Ryuji Kawano   +3 more
wiley   +2 more sources

Amino Acid Transporters and Release of Hydrophobic Amino Acids in the Heterocyst-Forming Cyanobacterium Anabaena sp. Strain PCC 7120

Life, 2015
Anabaena sp. strain PCC 7120 is a filamentous cyanobacterium that can use inorganic compounds such as nitrate or ammonium as nitrogen sources. In the absence of combined nitrogen, it can fix N2 in differentiated cells called heterocysts.
Rafael Pernil, Silvia Picossi, Antonia Herrero, Enrique Flores, Vicente Mariscal   +4 more
doaj   +1 more source

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

Valorphins alter physicochemical characteristics of phosphatidylcholine membranes: Datasets on lipid packing, bending rigidity, specific electrical capacitance, dipole potential, vesicle size

Data in Brief, 2022
Endogenous hemorphins are being intensively investigated as therapeutic agents in neuropharmacology, and also as biomarkers in mood regulation, inflammation and oncology.
Victoria Vitkova, Galya Staneva, Rusina Hazarosova, Stela I. Georgieva, Iva Valkova, Krassimira Antonova, Petаr Todorov   +6 more
doaj   +1 more source

Crystal structure and hydrogen bonding in N-(1-deoxy-β-d-fructopyranos-1-yl)-2-aminoisobutyric acid

Acta Crystallographica Section E: Crystallographic Communications, 2018
The title compound, alternatively called d-fructose-2-aminoisobutyric acid (FruAib), C10H19NO7, (I), crystallizes exclusively in the β-pyranose form, with two conformationally non-equivalent molecules [(IA) and (IB)] in the asymmetric unit.
Valeri V. Mossine, Charles L. Barnes, Thomas P. Mawhinney   +2 more
doaj   +1 more source

Leucine Reduced Blood–Brain Barrier Disruption and Infarct Size in Early Cerebral Ischemia-Reperfusion

Brain Sciences, 2023
A disruption of the blood–brain barrier (BBB) is a crucial pathophysiological change that can impact the outcome of a stroke. Ribosomal protein S6 (S6) and protein kinase B (Akt) play significant roles in early cerebral ischemia-reperfusion injury ...
Oak Z. Chi, Xia Liu, Jedrick Magsino, Harvey R. Weiss   +3 more
doaj   +1 more source

Factors Influencing Production of Fusaristatin A in Fusarium graminearum

Metabolites, 2015
Fusarium graminearum is a ubiquitous plant pathogen, which is able to produce several bioactive secondary metabolites. Recently, the cyclic lipopeptide fusaristatin A was isolated from this species and the biosynthetic gene cluster identified ...
Anne Hegge, Rikke Lønborg, Ditte Møller Nielsen, Jens Laurids Sørensen   +3 more
doaj   +1 more source

β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury

Molecular Medicine, 2023
Background Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain amino acids (BCAA) metabolism can protect against cardiac I/R injury, which may be related to bioactive molecules ...
Ziyue Zhang, Xingbing Li, Jingwen Guo, Bo He, Lianpan Wu, Rongpei Yang, Xingyue Li, Dandong Fang, XiaoLi Yang, Donghai Yang, Fengxian Wang, Ming Tang, Yu Han, Pedro A. Jose, Hongyong Wang, Chunyu Zeng   +15 more
doaj   +1 more source