Results 31 to 40 of about 3,558 (167)

Alpha-aminoisobutyric acid uptake in primary cultures of astrocytes [PDF]

Neurochemical Research, 1982
Homotypically pure cultures of rat brain astrocytes were used to examine some aspects of non-neuronal A-system (alanine preferring) amino acid uptake. The A-system specific probe, alpha-aminoisobutyric acid is transported rapidly, and a steady state distribution ratio of 9-25 is reached after 30 minute incubations. Kinetic estimates derived from uptake
Sellinger, Otto Z., Cummins, C. J., Glover, Roy A.   +2 more
openaire   +3 more sources

Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases

Nutrition & Metabolism, 2022
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining health and homeostasis. Although white adipose tissue and brown adipose tissue are currently considered key endocrine organs, they differ functionally and ...
Sabrina Azevedo Machado, Gabriel Pasquarelli-do-Nascimento, Debora Santos da Silva, Gabriel Ribeiro Farias, Igor de Oliveira Santos, Luana Borges Baptista, Kelly Grace Magalhães   +6 more
doaj   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Amino Acid Metabolism in Multiple Sclerosis: Analyzing Plasma and Cerebrospinal Fluid Profiles for Biomarker Discovery and Pathophysiological Insights

Cumhuriyet Science Journal
Multiple sclerosis (MS) is a neuroinflammatory disease associated with involving metabolic disruptions. Although amino acid metabolism is linked to MS pathophysiology, its role remains unclear.
Sümeyra Kaplan, Burhanettin Çiğdem, Şeyda Figül Gökçe, Hayrettin Yavuz, Halef Okan Dogan   +4 more
doaj   +1 more source

A Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina

Molecules, 2018
Soil fungi are known to contain a rich variety of defense metabolites that allow them to compete with other organisms (fungi, bacteria, nematodes, and insects) and help them occupy more preferential areas at the expense of effective antagonism.
Eugene A. Rogozhin, Vera S. Sadykova, Anna A. Baranova, Alexey S. Vasilchenko, Vladislav A. Lushpa, Konstantin S. Mineev, Marina L. Georgieva, Alexander B. Kul’ko, Mikhail E. Krasheninnikov, Alexey V. Lyundup, Anastasia V. Vasilchenko, Yaroslav A. Andreev   +11 more
doaj   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

A Journey into the Blue: Current Knowledge and Emerging Insights into Marine-Derived Peptaibols

Marine Drugs
Peptaibols represent a large family of membrane-active, linear fungal peptides, with variable lengths from 5 to 21 α–amino acid residues. As products of nonribosomal peptide synthetase (NRPS) biosynthetic machinery, they encompass several non ...
Claudia Finamore, Carmen Festa, Mattia Cammarota, Simona De Marino, Maria Valeria D’Auria   +4 more
doaj   +1 more source

Severe child form of primary hyperoxaluria type 2 - a case report revealing consequence of GRHPR deficiency on metabolism

BMC Medical Genetics, 2017
Background Primary hyperoxaluria type 2 is a rare monogenic disorder inherited in an autosomal recessive pattern. It results from the absence of the enzyme glyoxylate reductase/hydroxypyruvate reductase (GRHPR).
Jana Konkoľová, Ján Chandoga, Juraj Kováčik, Marcel Repiský, Veronika Kramarová, Ivana Paučinová, Daniel Böhmer   +6 more
doaj   +1 more source

C‐Terminal Nucleobase Modification Amplifies Peptide‐Mediated Liposome Fusion

Chemistry – A European Journal, EarlyView.
Let's come together right now. Cationic peptides are known to promote aggregation of negatively charged liposomes through electrostatic interaction. The process is reversible: once neutrality is achieved, liposomes disaggregate. Here, we demonstrate that end‐capping peptides with nucleobases turns the process into irreversible fusion.
Laura Morbiato, Giacomo Bettin, Chiara Dalla Torre, Lorenzo Stella, Marta De Zotti   +4 more
wiley   +1 more source

Utilization of glucose, alanine, lactate, and glycerol as lipogenic substrates by periuterine adipose tissue in situ in fed and starved rats.

Journal of Lipid Research, 1988
A technique previously used to study placental transfer in pregnant rats, consisting of labeled tracer infusion through the left uterine artery, was employed to determine the utilization of lipogenic substrates by periuterine adipose tissue in the fed ...
M Palacín, M A Lasunción, E Herrera
doaj   +1 more source