Results 51 to 60 of about 6,130 (209)

A Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina

Molecules, 2018
Soil fungi are known to contain a rich variety of defense metabolites that allow them to compete with other organisms (fungi, bacteria, nematodes, and insects) and help them occupy more preferential areas at the expense of effective antagonism.
Eugene A. Rogozhin, Vera S. Sadykova, Anna A. Baranova, Alexey S. Vasilchenko, Vladislav A. Lushpa, Konstantin S. Mineev, Marina L. Georgieva, Alexander B. Kul’ko, Mikhail E. Krasheninnikov, Alexey V. Lyundup, Anastasia V. Vasilchenko, Yaroslav A. Andreev   +11 more
doaj   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Synthesis of Dehydrodipeptide and N-ethyl-dehydrodipeptide Derivatives with an α-Aminoisobutyric Acid Residue [PDF]

, 2014
Several dipeptides with an N-benzyloxycarbonyl or an N-(tert-butyloxycarbonyl) α-aminoisobutyric acid residue and a β-hydroxyamino acid methyl ester were subjected to dehydration to form dehydrodipeptide derivatives.
Monteiro, Luís S., Pereira, Sofia, Pereira-Lima, Sílvia M. M. A.   +2 more
core  

Metabolic Modulation Predicts Heart Failure Tests Performance [PDF]

, 2019
The metabolic changes that accompany changes in Cardiopulmonary testing (CPET) and heart failure biomarkers (HFbio) are not well known. We undertook metabolomic and lipidomic phenotyping of a cohort of heart failure (HF) patients and utilized Multiple ...
Abbate, Antonio, Buckley, Leo F., Canada, Justin M., Carbone, Salvatore, Contaifer, Daniel, Jr., Kumar, Naren G., Morriss, Joshua M., Ranasinghe, Asanga D., Trankle, Cory, Van Tassell, Benjamin W., Wijesinghe, Dayanjan S., Wohlford, George   +11 more
core   +3 more sources

Alpha-aminoisobutyric acid uptake in primary cultures of astrocytes [PDF]

Neurochemical Research, 1982
Homotypically pure cultures of rat brain astrocytes were used to examine some aspects of non-neuronal A-system (alanine preferring) amino acid uptake. The A-system specific probe, alpha-aminoisobutyric acid is transported rapidly, and a steady state distribution ratio of 9-25 is reached after 30 minute incubations. Kinetic estimates derived from uptake
Sellinger, Otto Z., Cummins, C. J., Glover, Roy A.   +2 more
openaire   +3 more sources

C‐Terminal Nucleobase Modification Amplifies Peptide‐Mediated Liposome Fusion

Chemistry – A European Journal, EarlyView.
Let's come together right now. Cationic peptides are known to promote aggregation of negatively charged liposomes through electrostatic interaction. The process is reversible: once neutrality is achieved, liposomes disaggregate. Here, we demonstrate that end‐capping peptides with nucleobases turns the process into irreversible fusion.
Laura Morbiato, Giacomo Bettin, Chiara Dalla Torre, Lorenzo Stella, Marta De Zotti   +4 more
wiley   +1 more source

Solvent Effects on the Conformational Preferences of 2,6‐Pyridylcarboxamide Foldamers

Chemistry – A European Journal, EarlyView.
The marked effect of organic solvents and water/methanol mixtures on the conformational preferences of a soluble chiral foldamer has been established in a diverse array of seventeen distinct environments. ABSTRACT The marked influence of organic solvents and water on the conformational preferences of a chiral, soluble 2,6‐pyridylcarboxamide foldamer ...
Alexander R. Davis, Sena Öztürk, Kushal Samanta, Louise Male, Adam A. L. Michalchuk, Sarah J. Pike   +5 more
wiley   +1 more source

The cationic tetradecapeptide mastoparan as a privileged structure for drug discovery: Enhanced antimicrobial properties of mitoparan analogues modified at position-14 [PDF]

, 2018
Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing ...
Howl, John, Howl, Lewis, Jones, Sarah
core   +1 more source

Composite membranes comprising of polymeric and molecular amines embedded in poly(vinyl alcohol) matrices to facilitate CO2/H2 separation

The Canadian Journal of Chemical Engineering, EarlyView.
Polymeric and molecular amines embedded in hygroscopic matrices to facilitate CO2 transport for CO2/H2 separation. Abstract This work dealt with composite membranes comprising of polyvinylamine (PVAm) and triethylenetetramine (TETA) embedded in poly(vinyl alcohol) (PVA) for CO2/H2 separation via facilitated transport of CO2, where polymeric and ...
Steve Yijie Hu, Kean Wang, Xianshe Feng
wiley   +1 more source

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains [PDF]

, 2018
Alpha helices form a critical part of the binding interface for many protein-protein interactions, and chemically stabilized synthetic helical peptides can be effective inhibitors of such helix-mediated complexes.
Keating, Amy E., Letai, Anthony, Rezaei Araghi, Raheleh, Ryan, Jeremy Adam   +3 more
core   +1 more source