Results 51 to 60 of about 3,558 (167)

Syntheses and Properties of [1,1′-Bis(α-Aminoisobutyric Acid)]Gramicidin S and [1-α-Aminoisobutyric Acid]Semigramicidin S [PDF]

Bulletin of the Chemical Society of Japan, 1987
Abstract Analogs of gramicidin S, [1,1′-bis(α-aminoisobutyric acid)]gramicidin S (18) and [1-α-aminoisobutyric acid] semigramicidin S (11), have been synthesized by a conventional solution method. The cyclization reactions of a linear pentapeptide active ester and a linear decapeptide active ester yielded exclusively a protected cyclic ...
Michio Kondo, Mikio Kimura, Ken-ichi Sato, Hideaki Horimoto   +3 more
openaire   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, EarlyView.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

The muscle–intervertebral disc interaction mediated by L-BAIBA modulates extracellular matrix homeostasis and PANoptosis in nucleus pulposus cells

Experimental and Molecular Medicine
Upon engaging in physical activity, skeletal muscle synthesizes myokines, which not only facilitate crosstalk with various organs, including the brain, adipose tissue, bone, liver, gut, pancreas, and skin but also promote intramuscular signaling ...
Tianyu Qin, Ming Shi, Chao Zhang, Jiajun Wu, Zhengqi Huang, Xiaohe Zhang, Shuangxing Li, Yuliang Wu, Weitao Han, Bo Gao, Kang Xu, Song Jin, Wei Ye   +12 more
doaj   +1 more source

Integrated Metabolome and Microbiome Analysis Reveals the Regulatory Effects of Fermented Soybean Meal on the Gut Microbiota of Late Gestation

Fermentation
Late gestation is a critical period for regulating maternal peripartum physiological metabolism and gut microbiota balance. Fermented diets have been widely recognized as effective exogenous nutritional interventions capable of modulating the maintenance
Yantao Li, Lele Fu, Yushi Chen, Hua Yang, Yingping Xiao, Ying Ren, Cheng Wang   +6 more
doaj   +1 more source

Nutrition and Aromatic Components Analysis and Antioxidant Activity Evaluation of Gu Nin Chio Banana(Gu Nin Chio香蕉果实营养、香气成分分析及抗氧化活性评价) [PDF]

Shipin kexue jishu xuebao
To clarify the nutritional value, aromatic composition and anti oxidation activity of a newly introduced Gu Nin Chio banana in China, spectrophotometry, HPLC(high-performance liquid chromatography), ICP-MS (inductively coupled plasma-mass spectrometry ...
TAN Lin(谭琳), LI Sunjin(李孙锦), LIU Xingdi(刘兴地), LI Jingyang(李敬阳), CHEN Qingmian(陈清勉)   +4 more
doaj   +1 more source

Engineering Polymeric Membranes for CO₂ Separation: Materials, Fabrication, Challenges, and Future Perspectives

Carbon Neutralization, Volume 5, Issue 4, July 2026.
Overview of polymeric and mixed‐matrix membranes for CO₂ separation, highlighting key materials, fabrication techniques, performance challenges, and innovations supporting industrial decarbonization and sustainable development. ABSTRACT Carbon dioxide (CO₂) emissions from anthropogenic sources are major contributors to global warming and climate change,
Muhammad Mansha, Noreen Abass, Faizah Altaf, Shehzada Muhammad Sajid Jillani, Safyan Akram Khan, Shahid Ali   +5 more
wiley   +1 more source

Contemporary Applications of Chemical Libraries for Drug Discovery and Methods for Their Synthesis

ChemistryEurope, Volume 4, Issue 5, May 2026.
Screening of chemical libraries has over the past decades become a cornerstone of drug discovery. Today, a broad range of chemical libraries exist but they are often not well described in terms of diversity. This review describes current efforts which aim to visualize chemical diversity in compound collections and discuss current trends in synthetic ...
Tobias N. Hansen, Nils J. V. Hansen
wiley   +1 more source

Identification of blood biomarkers associated with hepatic lipid accumulation in aging laying hens with fatty liver

Poultry Science
Fatty Liver Hemorrhagic Syndrome (FLHS) is a metabolic disorder characterized by excessive hepatic triglycerides (TG) accumulation, primarily affecting high-producing, caged laying hens.
Zheng Wang, Dan Wang, Yijing Liu, Zeshun Jian, Minghui Wang, Hai Lin   +5 more
doaj   +1 more source

Beta-Aminoisobutyric Acid, A Possible Factor in Pyrimidine Metabolism.

Experimental Biology and Medicine, 1951
Summary(1) A compound frequently noted in a chromatographic study of urinary amino acids has now been isolated from the urines of two cancer patients and identified as beta-aminoisobutyric acid (BAIB). (2) In a group of 140 apparently healthy subjects, 52 individuals showed detectable urinary levels of BAIB (>0.15 millimole per liter), and three of ...
K, FINK, R B, HENDERSON, R M, FINK
openaire   +2 more sources