Results 61 to 70 of about 6,130 (209)

β‐Aminoisobutyric Acid Alleviates Cisplatin‐Induced Muscle Atrophy by Regulating E3 Ubiquitin Ligases, Apoptosis, Amino Acid Metabolism, Autophagy, and Ferroptosis

Medicine Bulletin, EarlyView.
ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang, Wen‐Bi He, Huan Wang, Hao Wang, Wen‐Jun Fang, Meng‐Qian Li, Jiong‐Xing Huang, Fei‐Peng Chen, Hui‐Guo Wang, Lin Zhu, Xiao‐Guang Liu   +10 more
wiley   +1 more source

Severe child form of primary hyperoxaluria type 2 - a case report revealing consequence of GRHPR deficiency on metabolism

BMC Medical Genetics, 2017
Background Primary hyperoxaluria type 2 is a rare monogenic disorder inherited in an autosomal recessive pattern. It results from the absence of the enzyme glyoxylate reductase/hydroxypyruvate reductase (GRHPR).
Jana Konkoľová, Ján Chandoga, Juraj Kováčik, Marcel Repiský, Veronika Kramarová, Ivana Paučinová, Daniel Böhmer   +6 more
doaj   +1 more source

Contemporary Applications of Chemical Libraries for Drug Discovery and Methods for Their Synthesis

ChemistryEurope, Volume 4, Issue 5, May 2026.
Screening of chemical libraries has over the past decades become a cornerstone of drug discovery. Today, a broad range of chemical libraries exist but they are often not well described in terms of diversity. This review describes current efforts which aim to visualize chemical diversity in compound collections and discuss current trends in synthetic ...
Tobias N. Hansen, Nils J. V. Hansen
wiley   +1 more source

Utilization of glucose, alanine, lactate, and glycerol as lipogenic substrates by periuterine adipose tissue in situ in fed and starved rats.

Journal of Lipid Research, 1988
A technique previously used to study placental transfer in pregnant rats, consisting of labeled tracer infusion through the left uterine artery, was employed to determine the utilization of lipogenic substrates by periuterine adipose tissue in the fed ...
M Palacín, M A Lasunción, E Herrera
doaj   +1 more source

Integrating the Field of Prebiotic Chemistry into a Christian Worldview [PDF]

, 2017
This thesis will provide an overarching examination into the scientific field of prebiotic chemistry, the purported chemistry of the formation of life on earth.
Anderson, Matthew B
core  

Pertussis toxin nullifies the depolarisation of the membrane potential and the stimulation of the rapid phase of 45Ca2+ entry through L-type calcium channels that are produced by follicle stimulating hormone in 10- to 12-day-old-rat Sertoli cells.

Frontiers in Physiology, 2010
The aim of this study was to evaluate the effect of pertussis toxin (PTX) on the depolarising component of the action of FSH on the membrane potential of Sertoli cells, which is linked to the rapid entry of Ca2+ into cells and to the Ca2+-dependent ...
Ana P Jacobus, Ana P Jacobus, Eloísa S Loss, Guillermo F Wassermann   +3 more
doaj   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Altered Urinary Amino Acids in Children With Autism Spectrum Disorders

Frontiers in Cellular Neuroscience, 2019
Autism spectrum disorders (ASD) affect 1% of children. Although there is no cure, early diagnosis and behavioral intervention can relieve the symptoms.
Aiping Liu, Wei Zhou, Liuhong Qu, Fusheng He, Hui Wang, Yan Wang, Chunquan Cai, Xiaoge Li, Wenhao Zhou, Mingbang Wang   +9 more
doaj   +1 more source

Genetic transformation of Fusarium avenaceum by Agrobacterium tumefaciens mediated transformation and the development of a USER-Brick vector construction system [PDF]

, 2014
BACKGROUND: The plant pathogenic and saprophytic fungus Fusarium avenaceum causes considerable in-field and post-field losses worldwide due to its infections of a wide range of different crops.
Frandsen, Rasmus John Normand, Khorsand-Jamal, Paiman, Larsen, Jesper Erup, Lysøe, Erik, Nielsen, Kristian Fog, Sorensen, Lisette Quaade   +5 more
core   +2 more sources

EPR of Gamma Irradiated Nα -Monochloroacetyl-α-Aminoisobutyric Acid

Zeitschrift für Naturforschung A, 2004
Electron paramagnetic resonance of γ -irradiated single crystals of Nα -monochloroacetyl-α-aminoisobutyric acid were investigated at room temperature and 130 K. The paramagnetic center as attributed to the (CH3)2 ˙CCOOH radical.
Baskan, MH, Osmanoglu, S
openaire   +1 more source