Results 41 to 50 of about 3,563 (171)

Synthesis and Characterization of Tritium‐Labeled Neuropeptide Y Y5 Receptor Ligands Derived From CGP71683A

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
From a synthesized series of 2,4‐diaminoquinazoline‐type Y5R ligands, three were prepared as tritium‐labeled compounds and characterized by saturation equilibrium binding at HEC‐1B‐hY5R cells. [3H]32 was further applied in a competition binding assay. High non‐specific binding of the radioligands prompted investigation of material‐dependent adsorption.
Franziska Schettler, Pierre Koch, Max Keller   +2 more
wiley   +1 more source

Composite membranes comprising of polymeric and molecular amines embedded in poly(vinyl alcohol) matrices to facilitate CO2/H2 separation

The Canadian Journal of Chemical Engineering, Volume 104, Issue 8, Page 4453-4463, August 2026.
Polymeric and molecular amines embedded in hygroscopic matrices to facilitate CO2 transport for CO2/H2 separation. Abstract This work dealt with composite membranes comprising of polyvinylamine (PVAm) and triethylenetetramine (TETA) embedded in poly(vinyl alcohol) (PVA) for CO2/H2 separation via facilitated transport of CO2, where polymeric and ...
Steve Yijie Hu, Kean Wang, Xianshe Feng
wiley   +1 more source

Recent data on obesity research: β-aminoisobutyric acid

Bratislava Medical Journal, 2014
The world-wide epidemic of obesity is now affecting up to a third of the adult population. Research attempting to contribute to management of this health scourge has been recently refocused on the essential role of physical activity. Muscle activity induces a dramatic increase in transcription of the peroxisome proliferator-activated receptor gamma ...
E, Ginter, V, Simko
openaire   +3 more sources

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Pertussis toxin nullifies the depolarisation of the membrane potential and the stimulation of the rapid phase of 45Ca2+ entry through L-type calcium channels that are produced by follicle stimulating hormone in 10- to 12-day-old-rat Sertoli cells.

Frontiers in Physiology, 2010
The aim of this study was to evaluate the effect of pertussis toxin (PTX) on the depolarising component of the action of FSH on the membrane potential of Sertoli cells, which is linked to the rapid entry of Ca2+ into cells and to the Ca2+-dependent ...
Ana P Jacobus, Ana P Jacobus, Eloísa S Loss, Guillermo F Wassermann   +3 more
doaj   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Altered Urinary Amino Acids in Children With Autism Spectrum Disorders

Frontiers in Cellular Neuroscience, 2019
Autism spectrum disorders (ASD) affect 1% of children. Although there is no cure, early diagnosis and behavioral intervention can relieve the symptoms.
Aiping Liu, Wei Zhou, Liuhong Qu, Fusheng He, Hui Wang, Yan Wang, Chunquan Cai, Xiaoge Li, Wenhao Zhou, Mingbang Wang   +9 more
doaj   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Properties of α-Aminoisobutyric Acid Transport in a Thermophilic Microorganism [PDF]

Journal of Bacteriology, 1974
Uptake of α-aminoisobutyric acid (AIB) by a leucine-tyrosine auxotroph of a thermophilic microorganism starved for leucine was studied. AIB was taken up by the cells against a substantial concentration gradient (300:1) and was present there in a free and unchanged form.
J, Reizer, N, Grossowicz
openaire   +2 more sources

Syntheses and Properties of [1,1′-Bis(α-Aminoisobutyric Acid)]Gramicidin S and [1-α-Aminoisobutyric Acid]Semigramicidin S [PDF]

Bulletin of the Chemical Society of Japan, 1987
Abstract Analogs of gramicidin S, [1,1′-bis(α-aminoisobutyric acid)]gramicidin S (18) and [1-α-aminoisobutyric acid] semigramicidin S (11), have been synthesized by a conventional solution method. The cyclization reactions of a linear pentapeptide active ester and a linear decapeptide active ester yielded exclusively a protected cyclic ...
Michio Kondo, Mikio Kimura, Ken-ichi Sato, Hideaki Horimoto   +3 more
openaire   +1 more source