Recent data on obesity research: β-aminoisobutyric acid
Bratislava Medical Journal, 2014 The world-wide epidemic of obesity is now affecting up to a third of the adult population. Research attempting to contribute to management of this health scourge has been recently refocused on the essential role of physical activity. Muscle activity induces a dramatic increase in transcription of the peroxisome proliferator-activated receptor gamma ...
E, Ginter, V, Simko
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Syntheses and Properties of [1,1′-Bis(α-Aminoisobutyric Acid)]Gramicidin S and [1-α-Aminoisobutyric Acid]Semigramicidin S [PDF]
Bulletin of the Chemical Society of Japan, 1987 Abstract Analogs of gramicidin S, [1,1′-bis(α-aminoisobutyric acid)]gramicidin S (18) and [1-α-aminoisobutyric acid] semigramicidin S (11), have been synthesized by a conventional solution method. The cyclization reactions of a linear pentapeptide active ester and a linear decapeptide active ester yielded exclusively a protected cyclic ...
Michio Kondo +3 more
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Aging-Driven Inter-Organ Crosstalk in Postmenopausal Osteoporosis: From Immunometabolic Drift to Multisystem Frailty. [PDF]
FASEB JPostmenopausal osteoporosis (PMOP) is increasingly recognized as an aging‐associated, multisystem state of fragility, in which estrogen deficiency exacerbates immune and metabolic drift across the bone marrow, skeletal muscle, adipose tissue, gut, vascular system, and neural circuits.
Rao X, Cai X.
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Stapled truncated orexin peptides as orexin receptor agonists [PDF]
, 2018 The peptides orexin-A and -B, the endogenous agonists of the orexin receptors, have similar 19-amino-acid C-termini which retain full maximum response as truncated peptides with only marginally reduced potency, while further N-terminal truncations ...
Karhu, Lasse +7 more
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Nutrition & Metabolism, 2022 Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining health and homeostasis. Although white adipose tissue and brown adipose tissue are currently considered key endocrine organs, they differ functionally and ...
Sabrina Azevedo Machado +6 more
doaj +1 more source
Metabolomics-based biomarker discovery for bee health monitoring : a proof of concept study concerning nutritional stress in Bombus terrestris [PDF]
, 2019 Bee pollinators are exposed to multiple natural and anthropogenic stressors. Understanding the effects of a single stressor in the complex environmental context of antagonistic/synergistic interactions is critical to pollinator monitoring and may serve ...
Meeus, Ivan +5 more
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Deletion of TSPO resulted in change of metabolomic profile in retinal pigment epithelial cells [PDF]
, 2019 Age-related macular degeneration is the main cause of vision loss in the aged population worldwide. Drusen, extracellular lesions formed underneath the retinal pigment epithelial (RPE) cells, are a clinical feature of AMD and associated with AMD ...
Abdulwahab Alamri +7 more
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QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study
Advanced Science, EarlyView.The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda +8 more
wiley +1 more source
Gold(III)-Dithiocarbamato Peptidomimetics in the Forefront of the Targeted Anticancer Therapy: Preclinical Studies against Human Breast Neoplasia [PDF]
, 2014 Since the serendipitous discovery of cisplatin, platinum-based drugs have become well-established antitumor agents, despite the fact that their clinical use is limited by many severe side-effects.
Dou, Q. Ping +5 more
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Cumhuriyet Science JournalMultiple sclerosis (MS) is a neuroinflammatory disease associated with involving metabolic disruptions. Although amino acid metabolism is linked to MS pathophysiology, its role remains unclear.
Sümeyra Kaplan +4 more
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