Results 11 to 20 of about 3,563 (171)

Associations between plasma branched-chain amino acids, β-aminoisobutyric acid and body composition

Journal of Nutritional Science, 2016
Plasma branched-chain amino acids (BCAA) are elevated in obesity and associated with increased cardiometabolic risk. β-Aminoisobutyric acid (B-AIBA), a recently identified small molecule metabolite, is associated with decreased cardiometabolic risk ...
Annemarie Rietman, Takara L. Stanley, Clary Clish, Vamsi Mootha, Marco Mensink, Steven K. Grinspoon, Hideo Makimura   +6 more
doaj   +1 more source

β-Aminoisobutyric acid (L-BAIBA) is a novel regulator of mitochondrial biogenesis and respiratory function in human podocytes

Scientific Reports, 2023
Podocytes constitute an external layer of the glomerular filtration barrier, injury to which is a hallmark of renal disease. Mitochondrial dysfunction often accompanies podocyte damage and is associated with an increase in oxidative stress and apoptosis.
Irena Audzeyenka, Maria Szrejder, Dorota Rogacka, Stefan Angielski, Moin A. Saleem, Agnieszka Piwkowska   +5 more
doaj   +1 more source

Physiological competition of brain phenylalanine accretion: Initial pharmacokinetic analyses of aminoisobutyric and methylaminoisobutyric acids in Pahenu2−/− mice

Molecular Genetics and Metabolism Reports, 2015
Objective: Initial studies on the use of non-physiological amino acids (NPAAs) to block the accretion of Phe in the brain of Pahenu2−/− mice revealed that 2-aminoisobutyrate (AIB) and N-methyl-2-aminoisobutyrate (MAIB) were promising lead compounds whose
Kara R. Vogel, Garrett R. Ainslie, Brian Phillips, Erland Arning, Teodoro Bottiglieri, Danny D. Shen, K. Michael Gibson   +6 more
doaj   +1 more source

Amino Acids in Cerebrospinal Fluid of Patients with Aneurysmal Subarachnoid Haemorrhage: An Observational Study

Frontiers in Neurology, 2017
BackgroundThe authors are aware of only one article investigating amino acid concentrations in cerebrospinal fluid (CSF) in patients with ruptured intracranial aneurysms, and this was published 31 years ago.
Bartosz Sokół, Bartosz Urbaniak, Norbert Wąsik, Szymon Plewa, Agnieszka Klupczyńska, Roman Jankowski, Barbara Więckowska, Robert Juszkat, Zenon Kokot   +8 more
doaj   +1 more source

Metabolomic analysis of plasma from breast tumour patients. A pilot study

Journal of Public Health Research, 2021
Background: Patients at risk of breast cancer are submitted to mammography, resulting in a classification of the lesions following the Breast Imaging Reporting and Data System (BI-RADS®). Due to BI-RADS 3 classification problems and the great uncertainty
Carola Politi, Claudia Fattuoni, Alessandra Serra, Antonio Noto, Silvia Loi, Andrea Casanova, Gavino Faa, Alberto Ravarino, Luca Saba   +8 more
doaj   +1 more source

Synthesis of enantiomerically enriched (R)-13C-labelled 2-aminoisobutyric acid (Aib) by conformational memory in the alkylation of a derivative of L-alanine

Beilstein Journal of Organic Chemistry, 2011
The method of Kouklovsky and coworkers for the enantioselective alkylation of cyclic N-naphthoyl derivatives of amino acids was used to introduce a 13C label into one of the two enantiotopic methyl groups of 2-aminoisobutyric acid (Aib) by retentive ...
Stephen P. Fletcher, Jordi Solà, Dean Holt, Robert A. Brown, Jonathan Clayden   +4 more
doaj   +1 more source

Metabolism of α-Aminoisobutyric Acid by Soil Bacteria [PDF]

Journal of Bacteriology, 1969
Eleven different bacteria, isolated by enrichment procedures on α-aminoisobutyric (AIB) as sole fixed nitrogen source, were examined for the mechanism by which they attacked the amino acid. All eleven organisms, including one which grew well on isopropylamine, converted AIB to acetone and CO 2 and showed an absolute
openaire   +2 more sources

Promising Approaches to Optimize the Biological Properties of the Antimicrobial Peptide Esculentin-1a(1–21)NH2: Amino Acids Substitution and Conjugation to Nanoparticles

Frontiers in Chemistry, 2017
Antimicrobial peptides (AMPs) represent an interesting class of molecules with expanding biological properties which make them a viable alternative for the development of future antibiotic drugs.
Bruno Casciaro, Floriana Cappiello, Mauro Cacciafesta, Maria Luisa Mangoni   +3 more
doaj   +1 more source

Toxicity and protein composition of venoms of Hottentotta saulcyi, Hottentotta schach and Androctonus crassicauda, three scorpion species collected in Iran

Veterinary Medicine and Science, 2021
Background Scorpion stings comprise a serious problem throughout the globe, especially in regions where they are more frequent. Despite a recent upsurge of interest in scorpion venoms by various research groups, there remain many challenges.
Ani Boghozian, Habibollah Nazem, Mohammad Fazilati, Seyed Hossein Hejazi, Mohammadreza Sheikh Sajjadieh   +4 more
doaj   +1 more source

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources