Results 11 to 20 of about 3,840 (168)

Multicomponent Stapling of Glucagon-Like Peptide-1 Enables Receptor-Guided PROTAC Delivery. [PDF]

Angew Chem Int Ed Engl
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Venne JL, Krajcovicova S, Davies G, Bolt H, Revell J, Spring DR.   +5 more
europepmc   +3 more sources

Metabolite Signatures in Postpartum Prediabetes and Diabetes Among Indian Women With Prior Gestational Diabetes Mellitus: Insights From CHIP-F Study. [PDF]

Diabetes Metab Res Rev
Metabolite Signatures in Postpartum Prediabetes and Diabetes Among Indian Women With Prior Gestational Diabetes Mellitus: Insights From CHIP‐F Study. ABSTRACT Aims Gestational diabetes mellitus (GDM) increases the risk of postpartum dysglycaemia. This study investigates candidate metabolites and perturbed metabolic pathways associated with postpartum ...
Kapoor S, Singh A, Mahlawat N, Manivannan J, Singh A, Bhatnagar S, Tandon N, Gupta Y, Kshetrapal P.   +8 more
europepmc   +2 more sources

Detection and Excretion Profile of Retatrutide in Human Plasma and Urine by LC-HRMS: Implications for Antidoping Analysis. [PDF]

Rapid Commun Mass Spectrom
ABSTRACT Rationale Retatrutide (LY3437943) is a novel long‐acting triple incretin receptor agonist that targets the glucagon‐like peptide‐1 receptor (GLP‐1R), glucose‐dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR). Its pronounced effects on body composition and metabolic health, combined with increasing off‐label use
Carneiro GRA, da Costa Nunes IK, Dos Santos Cardoso GR, Dos Santos PF, Padilha MC, Nogueira FCS, Pereira HMG.   +6 more
europepmc   +2 more sources

Tetradecanuclear {Ni₉Ln₅} Clusters Featuring Encapsulated {Ln₅} Trigonal Bipyramids: Modular 3d-4f Architectures With Broad-Range Magnetocaloric Response. [PDF]

Chemistry
The use of 2‐aminoisobutyric acid in 3d–4f chemistry affords three {Ni₉Ln5} clusters, with the Gd analogue exhibiting an unusually broad magnetocaloric effect across an extended temperature range. ABSTRACT The solvothermal reaction between Ni(HCOO)2.2H2O, 2‐aminoisobutyric acid (aibH), Ln(OAc)3·4H2O (Ln = Gd, Y, Dy) and NEt3 in MeOH/MeCN affords the ...
Tziotzi TG, Asmargiannaki EG, Thamm B, Dalgarno SJ, Charkiolakis EK, Cervera MUI, Gracia D, Evangelisti M, Milios CJ.   +8 more
europepmc   +2 more sources

Music and Exercise in Concert: Uncovering Synergistic Mechanisms for Enhancing Brain Health and Cognitive Resilience-A Narrative Review. [PDF]

Brain Behav
Music and physical exercise share convergent neurobiological mechanisms, including neuroplasticity, metabolic regulation, and neuroinflammatory modulation. Integrating music with exercise produces synergistic effects that enhance brain function beyond single interventions.
Yang S, Liu Q, Wang M, Zhang Y.
europepmc   +2 more sources

Saliva Metabolomics in Dry Mouth Patients with Head and Neck Cancer or Sjögren’s Syndrome

Cells, 2022
The etiology of dry mouth conditions is multi-faceted. Patients radiated after head and neck cancer (HNC) and those with primary Sjögren’s syndrome (pSS) share many of the same symptoms despite different causes.
Håvard Hynne, Elise Mørk Sandås, Katja Benedikte Prestø Elgstøen, Helge Rootwelt, Tor P. Utheim, Hilde Kanli Galtung, Janicke Liaaen Jensen   +6 more
doaj   +1 more source

β-Aminoisobutyric acid (L-BAIBA) is a novel regulator of mitochondrial biogenesis and respiratory function in human podocytes

Scientific Reports, 2023
Podocytes constitute an external layer of the glomerular filtration barrier, injury to which is a hallmark of renal disease. Mitochondrial dysfunction often accompanies podocyte damage and is associated with an increase in oxidative stress and apoptosis.
Irena Audzeyenka, Maria Szrejder, Dorota Rogacka, Stefan Angielski, Moin A. Saleem, Agnieszka Piwkowska   +5 more
doaj   +1 more source

Amino Acids in Cerebrospinal Fluid of Patients with Aneurysmal Subarachnoid Haemorrhage: An Observational Study

Frontiers in Neurology, 2017
BackgroundThe authors are aware of only one article investigating amino acid concentrations in cerebrospinal fluid (CSF) in patients with ruptured intracranial aneurysms, and this was published 31 years ago.
Bartosz Sokół, Bartosz Urbaniak, Norbert Wąsik, Szymon Plewa, Agnieszka Klupczyńska, Roman Jankowski, Barbara Więckowska, Robert Juszkat, Zenon Kokot   +8 more
doaj   +1 more source

Synthesis of enantiomerically enriched (R)-13C-labelled 2-aminoisobutyric acid (Aib) by conformational memory in the alkylation of a derivative of L-alanine

Beilstein Journal of Organic Chemistry, 2011
The method of Kouklovsky and coworkers for the enantioselective alkylation of cyclic N-naphthoyl derivatives of amino acids was used to introduce a 13C label into one of the two enantiotopic methyl groups of 2-aminoisobutyric acid (Aib) by retentive ...
Stephen P. Fletcher, Jordi Solà, Dean Holt, Robert A. Brown, Jonathan Clayden   +4 more
doaj   +1 more source

Differential Analysis of Amino Acids and Their Derivative Metabolites in Lychee Wine Fermented at Different Temperatures Based on Untargeted Metabolomics [PDF]

Zhongguo niangzao
To elucidate the effect of fermentation temperature on the composition of amino acid and derivative metabolites in lychee wine, the differences in amino acids and their derivatives in lychee wine fermented at 10, 20, and 30 ℃ were investigate with liquid
CHEN Liping, HU Xueling, LIU Mengtong, PENG Yongcong, SHI Zhangyan, ZHANG Lin, ZHONG Qiuping
doaj   +1 more source