Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes. [PDF]
Diabetes Obes MetabAbstract Background Elevated branched‐chain amino acids (BCAAs; leucine, valine, isoleucine) are linked to type 2 diabetes (T2D) risk, characterised by defective insulin secretion in pancreatic β‐cell and peripheral insulin resistance. Causative interaction between BCAA metabolism and these two diabetic pathogenesis remains unclear.
Zhou X, Lu J, Wang Z, Cheng KK, Li GH.
europepmc +2 more sources
Anti-Inflammatory Effects of <i>Hermetia illucens</i> Fermented With Riboflavin-Producing <i>Leuconostoc mesenteroides</i>KCCM13067P in RAW 264.7 Cells and Colitis Mouse Model. [PDF]
Food Sci NutrFermentation of Hermetia illucens with riboflavin‐producing Leuconostoc mesenteroides KCCM13067P enhanced vitamin B2 derivatives and bioactive metabolites, including amino acids and amines. The fermented product (HeHi_Lm) suppressed inflammatory responses in LPS‐stimulated RAW 264.7 macrophages and alleviated DSS‐induced colitis in mice.
Son SJ +5 more
europepmc +2 more sources
A Novel Multimodal LC-MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF. [PDF]
J Inherit Metab DisABSTRACT Metabolic testing of cerebrospinal fluid (CSF) is essential for early diagnosis of neurometabolic disorders. However, the large number of differential diagnoses, the phenotypic variance within a clinical picture, and the disease rarity complicate targeted metabolic diagnostics.
Christ S +8 more
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Turn-Induction in Peptides Incorporating Novel Cyrene-Derived α,α-Disubstituted Amino Acid. [PDF]
J Pept SciNovel chiral cyrene‐derived Cyr residues were incorporated into peptides. The α,α‐disubstituted amino acid residue was introduced using the Ugi reaction. X‐ray crystallographic analysis of R‐ and S‐Cyr residues indicated preference to adopt left‐ and right‐handed α‐helical conformations, respectively.
Bhowal KB, Hitti R, Lubell WD.
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Crystallization and 1.6 Å resolution crystal structure of an acylated GLP-1/GIP analogue peptide. [PDF]
Acta Crystallogr F Struct Biol CommunThe 1.6 Å resolution diffraction and subsequent structure solution of an acylated GLP‐1/GIP analogue lipopeptide is reported. This represents the first published data on the crystal structure of an unbound GLP‐1 and/or GIP analogue lipopeptide.With the meteoric rise in interest in GLP‐1 and GIP analogue peptides in recent years, there is a drive for ...
Mitchell HM +3 more
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Skeletal muscles and gut microbiota-derived metabolites: novel modulators of adipocyte thermogenesis
Frontiers in Endocrinology, 2023 Obesity occurs when overall energy intake surpasses energy expenditure. White adipose tissue is an energy storage site, whereas brown and beige adipose tissues catabolize stored energy to generate heat, which protects against obesity and obesity ...
Yi Tang +5 more
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Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children [PDF]
, 2015 Enteric infections, enteropathy and undernutrition in early childhood are preventable risk factors for child deaths, impaired neurodevelopment, and later life metabolic diseases.
Guerrant, RL +10 more
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New approaches to investigating the function of mycelial networks [PDF]
, 2005 Fungi play a key role in ecosystem nutrient cycles by scavenging, concentrating, translocating and redistributing nitrogen. To quantify and predict fungal nitrogen redistribution, and assess the importance of the integrity of fungal networks in soil for ...
Boddy, Lynne +6 more
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A Novel Pathway for Metabolism of the Cardiovascular Risk Factor Homoarginine by alanine:glyoxylate aminotransferase 2 [PDF]
, 2016 Low plasma concentrations of L-homoarginine are associated with an increased risk of cardiovascular events, while homoarginine supplementation is protective in animal models of metabolic syndrome and stroke.
Bode-Böger, SM +12 more
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Porcine Health Management, 2022 Background As a nutritive feed additive, guanidine acetic acid (GAA) participates in the metabolism of energy and proteins. This study aimed to investigate the effects of GAA on growth performance, organ index, plasma and tissue free amino acid profiles,
Yiyan Cui +7 more
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