Results 41 to 50 of about 6,885 (219)

β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury

open access: yesMolecular Medicine, 2023
Background Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain amino acids (BCAA) metabolism can protect against cardiac I/R injury, which may be related to bioactive molecules ...
Ziyue Zhang   +15 more
doaj   +1 more source

Metabolomics-based biomarker discovery for bee health monitoring : a proof of concept study concerning nutritional stress in Bombus terrestris [PDF]

open access: yes, 2019
Bee pollinators are exposed to multiple natural and anthropogenic stressors. Understanding the effects of a single stressor in the complex environmental context of antagonistic/synergistic interactions is critical to pollinator monitoring and may serve ...
Meeus, Ivan   +5 more
core   +2 more sources

Differential diagnosis of (inherited) amino acid metabolism or transport disorders [PDF]

open access: yes, 1992
__Abstract__ Disorders of amino acid metabolism or transport are most clearly expressed in urine. Nevertheless the interpretation of abnormalities in urinary amino acid excretion remains difficult. An increase or decrease of almost every amino acid in
Blom, W.A.M. (Wim)   +1 more
core   +7 more sources

Recent data on obesity research: β-aminoisobutyric acid

open access: yesBratislava Medical Journal, 2014
The world-wide epidemic of obesity is now affecting up to a third of the adult population. Research attempting to contribute to management of this health scourge has been recently refocused on the essential role of physical activity. Muscle activity induces a dramatic increase in transcription of the peroxisome proliferator-activated receptor gamma ...
E, Ginter, V, Simko
openaire   +3 more sources

Syntheses and Properties of [1,1′-Bis(α-Aminoisobutyric Acid)]Gramicidin S and [1-α-Aminoisobutyric Acid]Semigramicidin S [PDF]

open access: yesBulletin of the Chemical Society of Japan, 1987
Abstract Analogs of gramicidin S, [1,1′-bis(α-aminoisobutyric acid)]gramicidin S (18) and [1-α-aminoisobutyric acid] semigramicidin S (11), have been synthesized by a conventional solution method. The cyclization reactions of a linear pentapeptide active ester and a linear decapeptide active ester yielded exclusively a protected cyclic ...
Michio Kondo   +3 more
openaire   +1 more source

Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases

open access: yesNutrition & Metabolism, 2022
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining health and homeostasis. Although white adipose tissue and brown adipose tissue are currently considered key endocrine organs, they differ functionally and ...
Sabrina Azevedo Machado   +6 more
doaj   +1 more source

Amino Acid Metabolism in Multiple Sclerosis: Analyzing Plasma and Cerebrospinal Fluid Profiles for Biomarker Discovery and Pathophysiological Insights

open access: yesCumhuriyet Science Journal
Multiple sclerosis (MS) is a neuroinflammatory disease associated with involving metabolic disruptions. Although amino acid metabolism is linked to MS pathophysiology, its role remains unclear.
Sümeyra Kaplan   +4 more
doaj   +1 more source

A Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus Emericellopsis alkalina

open access: yesMolecules, 2018
Soil fungi are known to contain a rich variety of defense metabolites that allow them to compete with other organisms (fungi, bacteria, nematodes, and insects) and help them occupy more preferential areas at the expense of effective antagonism.
Eugene A. Rogozhin   +11 more
doaj   +1 more source

Diagnosis of dihydropyrimidinase deficiency in a Chinese boy with dihydropyrimidinuria [PDF]

open access: yes, 2013
published_or_final_versio
Lam, CW   +5 more
core   +1 more source

Alpha-aminoisobutyric acid uptake in primary cultures of astrocytes [PDF]

open access: yesNeurochemical Research, 1982
Homotypically pure cultures of rat brain astrocytes were used to examine some aspects of non-neuronal A-system (alanine preferring) amino acid uptake. The A-system specific probe, alpha-aminoisobutyric acid is transported rapidly, and a steady state distribution ratio of 9-25 is reached after 30 minute incubations. Kinetic estimates derived from uptake
Sellinger, Otto Z.   +2 more
openaire   +3 more sources

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