Results 71 to 80 of about 8,541,382 (232)

Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis

Photochemical and Photobiological Sciences, 2018
The administration of 5-aminolevulinic acid (ALA) to generate enhanced intracellular levels of endogenous porphyrins is currently one of the most important approaches for photodynamic therapy (PDT) and photodiagnosis (PDD).
K. Tewari, I. Eggleston
semanticscholar   +1 more source

A low‐cost handheld device for monitoring cutaneous photosensitivity

Photochemistry and Photobiology, EarlyView.
The cutaneous photosensitivity detection (CPD) device is a handheld contact‐based measurement device using 405 nm excitation and red fluorescence detection for monitoring skin phototoxicity risk after photodynamic therapy (PDT) procedures involving systemic aminolaevulinic acid (ALA) induced protoporphyrin IX (PpIX) photosensitization.
Md Asaduzzaman Rasel, Ryan Beland, Shakir Khan, Tayyaba Hasan, Jonathan P. Celli   +4 more
wiley   +1 more source

Biallelic pathogenic hydroxymethylbilane synthase gene variants of a neurodegenerative disorder with progressive cystic leukoencephalopathy: a case report

Journal of Medical Case Reports
Background Heterozygous mutations of the hydroxymethylbilane synthase gene can lead to acute intermittent porphyria, with episodic abdominal pain and neuropsychiatric symptoms.
Gabriel Schacht, Miriam Elbracht, Anna-Elisabeth Minder, Thomas Stauch, Arzu Stoppe, Eva Lausberg, Martin Häusler   +6 more
doaj   +1 more source

Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

Nature Communications, 2017
The mechanisms of action of the antibacterial metalloid tellurite are unclear. Here, the authors show that tellurite induces an accumulation of hydroxyl radical and intermediates of heme biosynthesis inE.
Eduardo H. Morales, Camilo A. Pinto, Roberto Luraschi, Claudia M. Muñoz-Villagrán, Fabián A. Cornejo, Scott W. Simpkins, Justin Nelson, Felipe A. Arenas, Jeff S. Piotrowski, Chad L. Myers, Hirotada Mori, Claudio C. Vásquez   +11 more
doaj   +1 more source

5-Aminolevulinic acid-mediated sonosensitization of rat RG2 glioma cells in vitro

, 2016
Sonodynamic therapy (SDT) is a promising technique based on the ability of certain substances, called sonosensitizers, to sensitize cancer cells to non-thermal effects of low-energy ultrasound waves, allowing their destruction.
Krzysztof Bilmin, Wojciech Secomski, Tamara Kujawska, Andrzej Nowicki, Paweł Grieb   +4 more
core   +1 more source

Photodynamic diagnosis for skull invasion [PDF]

, 2008
OBJECTIVE: We present a case of a meningioma in which photodynamic diagnosis (PDD) using 5-aminolevulinic acid was very useful in identifying the cranial involvement. CLINICAL PRESENTATION: An 83-year-old woman presented with a bony, hard, immobile bulge
Nagata, Izumi, Hayashi, Yukishige, Suyama, Kazuhiko, Morofuji, Yoichi, Matsuo, Takayuki   +4 more
core   +1 more source

Time‐series multi‐omics analysis of micronutrient stress in Sorghum bicolor reveals iron and zinc crosstalk and regulatory network conservation

Plant Biology, EarlyView.
Overlap between Fe and Zn responsive gene regulatory networks (GRNs) were found, indicative of micronutrient crosstalk, and conservation of root and leaf GRNs and genes suggests strong constraint on homeostasis networks in plants. Abstract Micronutrient stress impacts growth, biomass production, and grain yield in crops.
A. Mishra, A. Bhat, S. Kumari, R. Sharma, J. Braynen, D. Tadesse, S. El Alaoui, S. Seaver, N. Grosjean, D. Ware, M. Xie, T. Paape   +11 more
wiley   +1 more source

Photodynamische Therapie (PDT) und wassergefiltertes Infrarot A (wIRA) bei Patienten mit therapierefraktären vulgären Hand- und Fußwarzen [PDF]

, 2005
Background: Common warts (verrucae vulgares) are human papilloma virus (HPV) infections with a high incidence and prevalence, most often affecting hands and feet, being able to impair quality of life.
Tittelbach, Jörg, Fluhr, Joachim Wilhelm, Bankova, Lora, Hoffmann, Gerd, Fuchs, Silke M., Elsner, Peter   +5 more
core  

Structural and Functional Characterisation of a Metagenome‐Derived CYP108D18 Reveals an Unusual Dioxygen‐Bound State and Selective Hydrocarbon Hydroxylation

Microbial Biotechnology, Volume 19, Issue 10, October 2026.
CYP108D18, identified from a hot spring metagenome, catalyses selective phenylcyclohexane hydroxylation. This P450 has an exceptionally low substrate‐bound heme redox potential. Crystal structures revealed an unusual dioxygen‐bound substrate‐free form and a persistent open active site upon substrate binding.
Simran Kundral, Peter D. Giang, Alicia M. Kirk, Julia B. Buczynski, Kasun S. A. Arachchige, Sunil K. Khare, Paul V. Bernhardt, Paul N. Evans, Luke W. Guddat, Stephen G. Bell, James J. De Voss   +10 more
wiley   +1 more source

Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer

Molecules, 2011
Aminolevulinic acid (ALA) is an endogenous metabolite normally formed in the mitochondria from succinyl-CoA and glycine. Conjugation of eight ALA molecules yields protoporphyrin IX (PpIX) and finally leads to formation of heme.
Jakub Golab, Kamil Bojarczuk, Małgorzata Wańczyk, Magdalena Winiarska, Magdalena Gabrysiak, Małgorzata Firczuk, Angelika Muchowicz, Małgorzata Wachowska   +7 more
doaj   +1 more source