δ‐aminolevulinic acid dehydratase (ALAD) is an important enzyme in tetrapyrrole synthesis. ALAD combines two δ‐aminolevulinic acid (δ‐ALA) molecules to form the pyrrole molecule, porphobilinogen, an important precursor for plant pigments involved in ...
Nabil Killiny +4 more
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In vitro evaluation of 5-aminolevulinic acid (ALA) loaded PLGA nanoparticles
Lei Shi,1 Xiuli Wang,1 Feng Zhao,2 Hansen Luan,2 Qingfeng Tu,1 Zheng Huang,3 Hao Wang,2 Hongwei Wang1,41Shanghai Skin Disease Hospital, Shanghai, People's Republic of China; 2National Pharmaceutical Engineering Research Center, China State Institute ...
Wang XL +7 more
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Improvement Effect of 5-Aminolevulinic Acid on Hyperlipidemia in Miniature Schnauzer Dogs: An Open Study in 5 Cases of One Pedigree [PDF]
This is the first study to examine the long-term effect of 5-aminolevulinic acid mainly on serum lipoproteins in dogs with hyperlipidemia. We studied 5 Miniature Schnauzer cases whose fasting serum total triglyceride and very-low-density lipoprotein of ...
Sakai, Aki +7 more
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Novel Bioconjugates of Aminolevulinic Acid with Vitamins
5-Aminolevulinic acid (ALA) and derivatives thereof have been successfully used in photodynamic cancer therapy (PDT). The synthesis of novel bioconjugates combining ALA with two lipophilic and one hydrophilic vitamins is reported.
Joanne Weber (2413990) +2 more
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Photodynamic diagnosis for skull invasion
OBJECTIVE: We present a case of a meningioma in which photodynamic diagnosis (PDD) using 5-aminolevulinic acid was very useful in identifying the cranial involvement. CLINICAL PRESENTATION: An 83-year-old woman presented with a bony, hard, immobile bulge
Nagata, Izumi +4 more
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Effects of 5-aminolevulinic acid on growth and amylase activity in the radish taproot [PDF]
5-Aminolevulinic acid (ALA) promotes the growth of plants by enhancing their photosynthetic activities, but there is little information on how ALA influences the metabolism of sugars produced by photosynthesis.
9849dab2-49a9-4d5d-ac06-b4ed9e4f02db +26 more
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Effects of 5-aminolevulinic acid-mediated sonodynamic therapy on macrophages
Jiali Cheng,1,* Xin Sun,1,2,* Shuyuan Guo,1,* Wei Cao,1 Haibo Chen,1 Yinghua Jin,1 Bo Li,1 Qiannan Li,1 Huan Wang,1 Zhu Wang,3 Qi Zhou,3 Peng Wang,3 Zhiguo Zhang,3 Wenwu Cao,3,4 Ye Tian1,21Division of Cardiology, the First Affiliated Hospital ...
Zhou Q +13 more
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Clinical Remission of Delta-Aminolevulinic Acid Dehydratase Deficiency Through Suppression of Erythroid Heme Synthesis [PDF]
Delta-aminolevulinic acid dehydratase-porphyria (ADP) is an autosomal recessive disorder of heme biosynthesis, caused by delta-aminolevulinic acid dehydratase deficiency (ALAD).(1) We report an important change in pathophysiological concepts and ...
Wilson, Paul +32 more
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Regulation of human liver delta-aminolevulinic acid synthase by bile acids
Aminolevulinic acid synthase 1 (ALAS1) is the rate-limiting enzyme of heme synthesis in the liver and is highly regulated to adapt to the metabolic demand of the hepatocyte.
Peyer, Anne-Kathrin +15 more
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Photodynamic therapy with methyl aminolevulinate in the treatment of basal cell carcinoma
The article presents the results of the studies on the effectiveness of treatment basal cell carcinoma of the skin with photodynamic therapy with 5-aminolevulinic acid and methyl aminolevulinate.
A. A. Kubanov +2 more
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