Results 41 to 50 of about 20,500 (163)

Heating reactivation of rats aminolevulinic acid dehydratase in lead poisoning. [PDF]

, 1988
Heat reactivation (60 degrees C for 5 minutes) of the red blood cells aminolevulinic acid dehydratase activity was studied in lead treated rats (0.25 to 5.0 mg/kg b.w., i.p., for 4 weeks). Complete enzyme reactivation occurs with lead blood concentration
RAIMONDI M, BUNGARO A, CHIESURA P., TREVISAN, ANDREA   +3 more
core   +1 more source

miR-145 mediates the anti-cancer stemness effect of photodynamic therapy with 5-aminolevulinic acid (ALA) in oral cancer cells

Journal of the Formosan Medical Association, 2018
5-Aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) has been used in the treatment of various precancerous and malignant lesions. Our previous work has demonstrated that ALA-PDT possesses the potential to serve as an adjuvant therapy against ...
Chih-Yuan Fang, Pei-Yin Chen, Dennis Chun-Yu Ho, Lo-Lin Tsai, Pei-Ling Hsieh, Ming-Yi Lu, Cheng-Chia Yu, Chuan-Hang Yu   +7 more
doaj   +1 more source

Role of Delta-aminolevulinic Acid in the Symptoms of Acute Porphyria [PDF]

, 2015
BACKGROUND: Attacks of neuropathic pain, usually abdominal, are characteristic of the acute porphyrias and accompanied by overproduction of heme-precursor molecules, specifically delta-aminolevulinic acid and porphobilinogen.
Meister, Raymond K, Bissell, D Montgomery, Lai, Jennifer C, Blanc, Paul D   +3 more
core   +1 more source

Enhanced Delivery of 5‐Aminolevulinic Acid by Lecithin Invasomes in 3D Melanoma Cancer Model [PDF]

, 2023
Photodynamic therapy (PDT) is a noninvasive therapeutic approach for the treatment of skin cancer and diseases. 5-Aminolevulinic acid is a prodrug clinically approved for PDT.
Alfredo Zito, Annalisa Caputo, Andrea Ragusa, Clara Piccirillo, Raffaele Filotico, Luca Salvatore, Gabriella Guida, Alessandra Quarta, Antonio Gaballo, Alessia Nito, Nunzia Gallo, Concetta Nobile, and Alessandra Quarta   +12 more
core   +1 more source

Assessment of the efficacy and safety of auricular keloids excision followed by 5-aminolevulinic acid photodynamic therapy

Photodiagnosis and Photodynamic Therapy
Background: Auricular keloids are a significant clinical challenge, which adversely affect the life of the patient at the level of aesthetic and psychological well-being. Despite various treatment modalities, a universally effective therapy has yet to be
Ziyue Lu, Ding Zhu, Yunchuan Yang, Huiling Kou, Xinying Li, Junbo Zhang   +5 more
doaj   +1 more source

5-Aminolevulinic acid-mediated sonosensitization of rat RG2 glioma cells in vitro

, 2016
Sonodynamic therapy (SDT) is a promising technique based on the ability of certain substances, called sonosensitizers, to sensitize cancer cells to non-thermal effects of low-energy ultrasound waves, allowing their destruction.
Krzysztof Bilmin, Wojciech Secomski, Tamara Kujawska, Andrzej Nowicki, Paweł Grieb   +4 more
core   +1 more source

Effect of 5-aminolevulinic acid-based photodynamic therapy via reactive oxygen species in human cholangiocarcinoma cells

, 2011
Cy Hyun Kim1,2, Chung-Wook Chung1, Kyung Ha Choi1, Jin-Ju Yoo1, Do Hyung Kim1,2, Young-IL Jeong1, Dae Hwan Kang1,21National Research and Development Center for Hepatobiliary Cancer, Research Institute for Convergence of Biomedical Science and Technology,
Jeong YI, Kim DH, Chung CW, Dae Hwan Kang, Kang DH, Kim CH, Chung-Wook Chung, Yoo JJ, Choi KH   +8 more
core   +1 more source

Biallelic pathogenic hydroxymethylbilane synthase gene variants of a neurodegenerative disorder with progressive cystic leukoencephalopathy: a case report

Journal of Medical Case Reports
Background Heterozygous mutations of the hydroxymethylbilane synthase gene can lead to acute intermittent porphyria, with episodic abdominal pain and neuropsychiatric symptoms.
Gabriel Schacht, Miriam Elbracht, Anna-Elisabeth Minder, Thomas Stauch, Arzu Stoppe, Eva Lausberg, Martin Häusler   +6 more
doaj   +1 more source

Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

Nature Communications, 2017
The mechanisms of action of the antibacterial metalloid tellurite are unclear. Here, the authors show that tellurite induces an accumulation of hydroxyl radical and intermediates of heme biosynthesis inE.
Eduardo H. Morales, Camilo A. Pinto, Roberto Luraschi, Claudia M. Muñoz-Villagrán, Fabián A. Cornejo, Scott W. Simpkins, Justin Nelson, Felipe A. Arenas, Jeff S. Piotrowski, Chad L. Myers, Hirotada Mori, Claudio C. Vásquez   +11 more
doaj   +1 more source

Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer

Molecules, 2011
Aminolevulinic acid (ALA) is an endogenous metabolite normally formed in the mitochondria from succinyl-CoA and glycine. Conjugation of eight ALA molecules yields protoporphyrin IX (PpIX) and finally leads to formation of heme.
Jakub Golab, Kamil Bojarczuk, Małgorzata Wańczyk, Magdalena Winiarska, Magdalena Gabrysiak, Małgorzata Firczuk, Angelika Muchowicz, Małgorzata Wachowska   +7 more
doaj   +1 more source