Results 31 to 40 of about 15,695 (155)
G‐Quadruplexes: Structural Diversity and Emerging Roles in Biomolecular Condensation
Advanced Science, EarlyView.G‐quadruplexes (G4s) fold into diverse intra‐ and intermolecular structures, positioning them as emerging regulators of biomolecular condensation. Mechanistically, G4s autonomously form condensates, act as structural platforms to initiate and stimulate condensation, or induce phase transitions.
Wenmeng Wang +5 more
wiley +1 more source
5-Aminolevulinic acid hydrochloride
IUCrDataThe crystal structure of 5-aminolevulinic acid hydrochloride (systematic name: 4-carboxy-2-oxobutan-1-aminium chloride), C5H10NO3+·Cl−, has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional ...
Jean guillaume Ducreux +3 more
doaj +1 more source
BMEMat, EarlyView.Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao +4 more
wiley +1 more source
Porphyria: What Is It and Who Should Be Evaluated?
Rambam Maimonides Medical Journal, 2018 The porphyrias are a group of rare metabolic disorders, inherited or acquired, along the heme biosynthetic pathway, which could manifest with neurovisceral and/or cutaneous symptoms, depending on the defective enzyme.
Yonatan Edel, Rivka Mamet
doaj +1 more source
Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity
VIEW, EarlyView.Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin +3 more
wiley +1 more source
ANZ Journal of Surgery, EarlyView.ABSTRACT Background There is compelling evidence that treating high‐grade squamous intraepithelial lesions (HSIL), the anal squamous cell cancer (ASCC) precursor, reduces the risk of developing ASCC. Using high‐resolution anoscopy (HRA), surgical excision, ablative and topical therapies are widely used to treat HSIL.
Matthew Joseph Marino +5 more
wiley +1 more source
Agriculture, 2023 Intensive poultry production may result in substantial emissions of pollutants into the environment, including pharmaceuticals and other chemicals used in poultry farming.
Magdalena Krupka +7 more
doaj +1 more source
Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes
The FEBS Journal, EarlyView.During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb +4 more
wiley +1 more source
Journal of the European Academy of Dermatology and Venereology, EarlyView.This single‐centre, randomized controlled trial showed that simulated daylight photodynamic therapy (SDL‐PDT, n = 785 lesions) was less effective than conventional photodynamic therapy (C‐PDT, n = 673 lesions) in treating mild to moderate actinic keratoses with 1‐year clearance rates of 71.0% for SDL‐PDT versus 85.3% for C‐PDT (p < 0.001). However, SDL‐
Alexandra Sjöholm +5 more
wiley +1 more source
Journal of the Formosan Medical Association, 2018 5-Aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) has been used in the treatment of various precancerous and malignant lesions. Our previous work has demonstrated that ALA-PDT possesses the potential to serve as an adjuvant therapy against ...
Chih-Yuan Fang +7 more
doaj +1 more source