Results 111 to 120 of about 41,379 (247)
, 2006 Racemic derivatives of 3-amino-2-tetralone were synthesised and evaluated for their ability to inhibit metallo-aminopeptidase activities. New compounds substituted in position 2 by methyl ketone, substituted oximes or hydroxamic acids as well as ...
Albrecht, S +5 more
core +1 more source
eLifeNew antimalarial drug candidates that act via novel mechanisms are urgently needed to combat malaria drug resistance. Here, we describe the multi-omic chemical validation of Plasmodium M1 alanyl metalloaminopeptidase as an attractive drug target using ...
Carlo Giannangelo +17 more
doaj +1 more source
Plant, Cell &Environment, Volume 49, Issue 12, Page 10283-10300, December 2026.ABSTRACT Arginine metabolism in plants is targeted by phytopathogens such as Pseudomonas syringae strains, which produce toxins that affect enzymes of plant arginine metabolism, causing devastating infections in crops. In this work, the structural and functional properties of plant N‐acetylornithine glutamate acetyltransferase (NAOGAT), the key ...
Maciej Nielipinski +3 more
wiley +1 more source
Zinc-dependent aminopeptidases: new perspectives on structure, function, and biomedical applications
Frontiers in Chemical BiologyZinc-dependent aminopeptidases are a subclass of exopeptidases implicated in the hydrolysis of N-terminal residues from peptides through a Zn(II) co-factor dependent hydrolytic mechanism. In humans, the prominent members of this class of enzymes (ERAP1/2,
Saleem Bhat
doaj +1 more source
Arthritis &Rheumatology, Volume 78, Issue 11, Page 2280-2291, November 2026.Objective Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Patients with lupus and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu +2 more
wiley +1 more source
Aminopeptidase N as a target for oral vaccine delivery
, 2010 Aminopeptidase N as a target for oral vaccine ...
Remon, Jean Paul +4 more
core
THE HISTOCHEMICAL DEMONSTRATION OF LEUCINE AMINOPEPTIDASE
, 1957 1. A method is described for the histochemical localization of leucine aminopeptidase in fresh frozen and paraffin embedded tissues. 2. Evidence is offered which supports the idea that the substrate l-leucyl-β-naphthylamide is hydrolyzed by leucine ...
MARVIN M. NACHLAS +2 more
core +1 more source
Immunity, Inflammation and Disease, Volume 14, Issue 11, November 2026.ABSTRACT Introduction Behçet's disease (BD) is a multisystem inflammatory vasculitis with clinical heterogeneity that may vary across ethnic groups within the same country. This study aimed to evaluate the influence of ethnicity on the clinical manifestations, immunogenic laboratory findings and disease course of BD by comparing Turkic and non‐Turkic ...
Shokufeh Sadeghi +7 more
wiley +1 more source
Journal of Environmental Quality, Volume 55, Issue 6, November/December 2026.Abstract Soils are increasingly receiving treated wastewater (TWW) to support crop production and protect natural resources. However, besides water, various inputs, such as soil nutrients (salts), organic carbon, and various contaminants of emerging concern, including antibiotics, antibiotic resistance genes, pharmaceutical compounds, heavy metals, and
Vasileios A. Tzanakakis +3 more
wiley +1 more source
Determination of aminopeptidase activity in cheese
, 2005 Aminopeptidase activity was studied in different types of cheese. Of the cheeses analysed having a mesophilous lactic flora, Roncal was contained the most aminopeptidase activity, coinciding with the highest ripening indices found [non-protein nitrogen ...
Martí De Castro, M. A. +3 more
core +1 more source