Results 11 to 20 of about 25,591 (179)

From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase

Frontiers in Pharmacology, 2020
It was reported three decades ago that intracerebroventricular injection of angiotensin IV (Ang IV, Val-Tyr-Ile-His-Pro-Phe) improved memory and learning in the rat. There are several explanations for these positive effects of the hexapeptide and related
Mathias Hallberg, Mats Larhed
doaj   +1 more source

Correlation Between Proteolytic Enzymes and Microangiogenesis in Degenerative Intervertebral Disc Nucleus

Journal of Investigative Surgery, 2021
Objective To investigate the correlation between proteolytic enzymes and microangiogenesis in degenerative intervertebral disc nucleus. Methods: Forty patients with degenerative disc nucleus pulposus who were admitted to our hospital were selected incase
Dong Chen, Xin Jiang
doaj   +1 more source

Aminopeptidase N inhibition could be involved in the anti-angiogenic effect of dobesilates [PDF]

Journal of the Serbian Chemical Society, 2015
Calcium, magnesium and zinc 2,5-dihydroxybenzenesulfonates (dobesilates) were synthesized by sulfonation of hydroquinone with sulfuric acid under mild conditions.
Farsa Oldřich, Sedláková Šárka, Podlipná Jana, Maxa Jaroslav   +3 more
doaj   +1 more source

Effects of silencing APN gene on proliferation, invasion and apoptosis of human glioma U251 cells

Di-san junyi daxue xuebao, 2020
Objective To determine the effect of aminopeptidase N (APN) on the proliferation, invasion, and apoptosis in human glioma U251 cells and to investigate the possible mechanism.
DONG Yunpeng, CHENG Yuan, CHEN Jin
doaj   +1 more source

Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia

Journal of Neuroinflammation, 2012
Background Cerebral inflammation is a hallmark of neuronal degeneration. Dipeptidyl peptidase IV, aminopeptidase N as well as the dipeptidyl peptidases II, 8 and 9 and cytosolic alanyl-aminopeptidase are involved in the regulation of autoimmunity and ...
Röhnert Peter, Schmidt Werner, Emmerlich Patrick, Goihl Alexander, Wrenger Sabine, Bank Ute, Nordhoff Karsten, Täger Michael, Ansorge Siegfried, Reinhold Dirk, Striggow Frank   +10 more
doaj   +1 more source

Impaired angiogenesis in aminopeptidase N-null mice [PDF]

Proceedings of the National Academy of Sciences, 2007
Aminopeptidase N (APN, CD13; EC 3.4.11.2) is a transmembrane metalloprotease with several functions, depending on the cell type and tissue environment. In tumor vasculature, APN is overexpressed in the endothelium and promotes angiogenesis. However, there have been no reports ofin vivoinactivation of the APN gene to validate these findings.
Roberto, Rangel, Yan, Sun, Liliana, Guzman-Rojas, Michael G, Ozawa, Jessica, Sun, Ricardo J, Giordano, Carolyn S, Van Pelt, Peggy T, Tinkey, Richard R, Behringer, Richard L, Sidman, Wadih, Arap, Renata, Pasqualini   +11 more
openaire   +2 more sources

Aminopeptidase N in arterial hypertension [PDF]

Heart Failure Reviews, 2007
Aminopeptidase N (APN) or CD13 is a conserved type II integral membrane zinc-dependent metalloprotease in the M1 family of ectoenzymes. APN is abundant in the kidneys and central nervous system. Identified substrates include Angiotensin III (Ang III); neuropeptides, including enkephalins and endorphins; and homones, including kallidan and somatostatin.
openaire   +2 more sources

CD13/aminopeptidase N in collagen vascular diseases [PDF]

Rheumatology International, 2003
To determine the significance of CD13/aminopeptidase N in collagen vascular diseases (CVD), we examined its activity and expression in sera and disease sites of patients with CVD. Significantly higher aminopeptidase activity was detected in bronchoalveolar lavage fluid from patients with interstitial lung diseases due to rheumatoid arthritis (RA ...
Dan, Hirohumi, Tani, Kenji, Hase, Kayoko, Shimizu, Teruki, Tamiya, Hiroyuki, Biraa, Yanjmaa, Huang, Luping, Yanagawa, Hiroaki, Sone, Saburo   +8 more
openaire   +2 more sources

Aminopeptidases do not directly degrade tau protein

Molecular Neurodegeneration, 2010
Background Tau hyperphosphorylation and aggregation to form intracellular neurofibrillar tangles is prevalent in a number of tauopathies. Thus there is current interest in the mechanisms involved in Tau clearance. It was recently reported that Tau can be
Hersh Louis B, Guan Hanjun, Chow K
doaj   +1 more source

Urinary aminopeptidase activities as early and predictive biomarkers of renal dysfunction in cisplatin-treated rats. [PDF]

PLoS ONE, 2012
This study analyzes the fluorimetric determination of alanyl- (Ala), glutamyl- (Glu), leucyl-cystinyl- (Cys) and aspartyl-aminopeptidase (AspAp) urinary enzymatic activities as early and predictive biomarkers of renal dysfunction in cisplatin-treated ...
Andrés Quesada, Félix Vargas, Sebastián Montoro-Molina, Francisco O'Valle, María Dolores Rodríguez-Martínez, Antonio Osuna, Isabel Prieto, Manuel Ramírez, Rosemary Wangensteen   +8 more
doaj   +1 more source