Results 51 to 60 of about 25,591 (179)

Activatable smart contrast agents for photoacoustic imaging

Smart Molecules, EarlyView.
This review highlights recent advances in smart activatable photoacoustic imaging (PAI) contrast agents, which dynamically modulate their optical properties in response to external stimuli or microenvironmental cues. It discusses their molecular design, activation mechanisms, biomedical applications, and future prospects for clinically tailored use ...
Donghyeon Oh, Jihye Lee, Suyoung Park, Juyoung Yoon, Won Jong Kim, Chulhong Kim   +5 more
wiley   +1 more source

Potential Activities and Long Lifetimes of Organic Carbon-Degrading Extracellular Enzymes in Deep Subsurface Sediments of the Baltic Sea

Frontiers in Microbiology, 2021
Heterotrophic microorganisms in marine sediments produce extracellular enzymes to hydrolyze organic macromolecules, so their products can be transported inside the cell and used for energy and growth. Therefore, extracellular enzymes may mediate the fate
Jenna M. Schmidt, Taylor M. Royalty, Karen G. Lloyd, Andrew D. Steen, Andrew D. Steen   +4 more
doaj   +1 more source

Necromass chemistry drives the functional diversity of the necrobiome, resulting in microbe–organic matter feedbacks

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract In temperate European forests, soil fungal communities, dominated by saprotrophic and ectomycorrhizal (ECM) species, represent almost 25% of soil organic carbon (C) in the soil.
Elsa Hilaire, Laure Fauchery, Michaël Danger, Aurélie Cébron, Bernhard Zeller, Marc Buée   +5 more
wiley   +1 more source

DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk

eLife, 2016
The aminopeptidase DPP9 removes dipeptides from N-termini of substrates having a proline or alanine in second position. Although linked to several pathways including cell survival and metabolism, the molecular mechanisms underlying these outcomes are ...
Daniela Justa-Schuch, Maria Silva-Garcia, Esther Pilla, Michael Engelke, Markus Kilisch, Christof Lenz, Ulrike Möller, Fumihiko Nakamura, Henning Urlaub, Ruth Geiss-Friedlander   +9 more
doaj   +1 more source

Positioning of Melflufen in Heavily Pretreated RRMM Patients: Real‐World Evidence in a Rapidly Evolving Therapeutic Landscape

European Journal of Haematology, EarlyView.
ABSTRACT Modern therapies have clearly marked the history of multiple myeloma (MM), leading to undisputed advantages in terms of sustained responses and prolonged survival, while progressively improving patients' quality of life. Nonetheless, disease recurrence and resistance to available therapies underscore the importance of identifying additional ...
K. Mancuso, S. Masci, M. Talarico, A. Vitale, S. Barbato, V. Solli, M. Puppi, I. Rizzello, L. Pantani, P. Tacchetti, M. Iezza, R. Restuccia, I. Sacchetti, E. Manzato, S. Ghibellini, S. Armuzzi, B. Taurisano, M. Cavo, E. Zamagni   +18 more
wiley   +1 more source

Tumor-derived aminopeptidase N promotes early stages of brain metastatic colonization

Cell Reports
Summary: Metastasis is a highly inefficient process, with the vast majority of disseminated cancer cells failing to form secondary tumors. To establish brain metastases, cancer cells must traverse the blood-brain barrier and rapidly adapt to the ...
Leire Bejarano, Alberto Hernández-Barranco, Vincent Roh, Rui Santalla Méndez, Eleni Lamprou, Catia F. Costa, Michelle Ballabio, Monika E. Hegi, Nadine Fournier, Johanna A. Joyce   +9 more
doaj   +1 more source

Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer

BMC Cancer, 2008
Background Radiotherapy can be used to treat all stages of cervical cancer. For improving local control via radiotherapy, it is important to use additional antitumor agents.
Nawa Akihiro, Terauchi Mikio, Kajiyama Hiroaki, Shibata Kiyosumi, Tsukamoto Hirohisa, Kikkawa Fumitaka   +5 more
doaj   +1 more source

Aminopeptidase N

, 2013
The third edition of the Handbook of Proteolytic Enzymes aims to be a comprehensive reference work for the enzymes that cleave proteins and peptides, and contains over 850 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing
openaire   +1 more source

The impact of accumulating immune adaptation in circulating strains of HIV‐1

HIV Medicine, EarlyView.
Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi, Alison Castley, Pooja Deshpande, Abha Chopra, David Nolan, Simon Mallal, Mina John, Silvana Gaudieri   +7 more
wiley   +1 more source

Crystal structure of X‐prolyl aminopeptidase fromCaenorhabditis elegans: A cytosolic enzyme with a di‐nuclear active site

FEBS Open Bio, 2015
Eukaryotic aminopeptidase P1 (APP1), also known as X‐prolyl aminopeptidase (XPNPEP1) in human tissues, is a cytosolic exopeptidase that preferentially removes amino acids from the N‐terminus of peptides possessing a penultimate N‐terminal proline residue.
Shalini Iyer, Penelope J. La-Borde, Karl A.P. Payne, Mark R. Parsons, Anthony J. Turner, R. Elwyn Isaac, K. Ravi Acharya   +6 more
doaj   +1 more source