Results 71 to 80 of about 25,591 (179)
Immunology, Volume 177, Issue 4, Page 752-765, April 2026.Our data show that suppressing IRF2, genetically or by siRNA, modulates PD‐L1 and MHC‐I levels. This induced immune‐evasive state critically underlies the significantly prolonged survival of cardiac allografts, revealing a novel therapeutic avenue.
Li Tian +5 more
wiley +1 more source
Feline aminopeptidase N is not a functional receptor for avian infectious bronchitis virus
Virology Journal, 2007 Background Coronaviruses are an important cause of infectious diseases in humans, including severe acute respiratory syndrome (SARS), and have the continued potential for emergence from animal species. A major factor in the host range of a coronavirus is
Harbison Carole E +6 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, Volume 600, Issue 5, Page 631-643, March 2026.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad +3 more
wiley +1 more source
Comparison of Three RT-PCR Based Methods for Relative Quantification of mRNA
Food Technology and Biotechnology, 2005 Comparison of three RT-PCR based methods: semi-quantitative, competitive and real--time RT-PCR for relative quantification of mRNA is presented. Aminopeptidase N expressed on human promyeloid HL-60 cell line, at basal and activated state, served as a ...
Andreja Ambriović-Ristov +4 more
doaj
Click Chemistry and Bioorthogonal Reaction for Aggregation‐Induced Emission Bioconjugates
Aggregate, Volume 7, Issue 3, March 2026.This review highlights the construction of AIE active bioconjugates via click chemical or bioorthogonal reactions, and their applications in biosensing, bioimaging, and image‐guided treatment. The challenges and perspectives in the area are also discussed.
Xinzhe Yang +3 more
wiley +1 more source
Recent Progress on Giant Molecules: Synthesis, Assembly, and Applications
Chemistry–Methods, Volume 6, Issue 3, March 2026.Giant molecules are molecules constructed by molecular nanoparticles with precise, rigid structure, have similar structures with small molecules and a large size as macromolecules. In this review, the constituent modules of giant molecules, as well as their synthesis, self‐assembly, applications in various fields and future developing prospect are ...
Haoyu Chen +7 more
wiley +1 more source
European Journal of Immunology, Volume 56, Issue 3, March 2026.Mouse Qa1b‐restricted T cells show promiscuous requirements for positive selection. Using in vivo tetramer enrichment, in vitro APC engineering, and in vitro thymocyte stimulation, we demonstrate that a Qa1b‐restricted T cell population can be selected by both Qa1b and H2‐T11, and depends on non‐cognate CD8‐MHC I binding.
Xiaokun Yang +7 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 2, March 2026.This randomized, double‐blind, placebo‐controlled trial demonstrated that probiotic supplementation in individuals with non‐celiac gluten/wheat sensitivity improved tolerance to gluten reintroduction in nearly half of participants. The effect was associated with beneficial shifts in gut microbiome composition and function, including enhanced microbial ...
Ilario Ferrocino +14 more
wiley +1 more source
The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach
Scientific Reports, 2017 The M1 family of metalloproteases represents a large number of exopeptidases that cleave single amino acid residues from the N-terminus of peptide substrates.
Shilvi Joshi +9 more
doaj +1 more source