Results 101 to 110 of about 6,120 (213)

Evaluation of α,β-unsaturated ketones as antileishmanial agents [PDF]

, 2015
In this study, we assessed the antileishmanial activity of 126 α,β-unsaturated ketones. The compounds NC901, NC884, and NC2459 showed high leishmanicidal activity for both the extracellular (50% effective concentration [EC(50)], 456 nM, 1,122 nM, and 20 ...
Beverley, Stephen M, Das, Umashankar, Dimmock, Jonathan R, Herrera, Linda J, Iniguez, Eva, Maldonado, Rosa A, Vasquez, Miguel A   +6 more
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Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines

Malaria Journal, 2018
Background Tafenoquine was recently approved for Plasmodium vivax radical cure (KRINTAFEL™) and malaria prevention (ARAKODA™). Methods A review of the non-clinical and clinical literature was conducted to assess whether tafenoquine (and primaquine ...
Jonathan Berman, Tracey Brown, Geoffrey Dow, Stephen Toovey   +3 more
doaj   +1 more source

Quantifying the Evolution and Impact of Antimalarial Drug Resistance: Drug Use, Spread of Resistance, and Drug Failure over a 12-Year Period in Papua New Guinea [PDF]

, 2017
Background. Antimalarial use is a key factor driving drug resistance and reduced treatment effectiveness in Plasmodium falciparum malaria, but there are few formal, quantitative analyses of this process. Methods.
Baea, Kay, Beck, Hans-Peter, Betschart, Bruno, Felger, Ingrid, Genton, Blaise, Hastings, Ian M., Marfurt, Jutta, Muüller, Ivo, Nsanzabana, Christian, Rare, Lawrence, Schapira, Allan, Smith, Thomas A.   +11 more
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Resistant Plasmodium Falciparum Infection From Samarinda, Kalimantan [PDF]

, 1974
Rumah Sakit Caltex di Rumbai, Pekanbaru pernah melaporkan adanya P. falciparum yang resistent terhadap chloroquine. Setelah dilakukan follow up ternyata kasus ini masih sangat sensitive terhadap group 4 aminoquinoline.
Arwati, A. (Arwati), Verdrager, J. (J)
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Aberraciones cromosomales en bulbos de cebolla Allium cepa inducidas por moléculas híbridas 4-aminoquinolínicas

Universitas Scientiarum, 2012
To study the toxicological properties of three hybrid compounds, quinoline-thiazolidinone (FR-72 and FR-121) and acridin-epoxyisoindolindione (FR- 154), applying named compounds to the test of the roots of Allium cepa onion bulbs.
Ricardo Restrepo Manrique, Diana Maria Reyes Quezada, Marlyn Catalina Ortiz Villamizar, Fernando A. Rojas Ruiz, Vladimir V. Kouznetsov   +4 more
doaj  

Structural Insight into the Mechanism of 4-Aminoquinolines Selectivity for the alpha2A-Adrenoceptor

Drug Design, Development and Therapy, 2020
Zaibing Li,1,2,* Jingyu Li,1,* Liyan Liu,1 Wenyi Deng,3 Qingrong Liu,4 Ruofan Liu,4 Wen Zhang,3 Zaiqing He,5 Lei Fan,6 Yingzhuo Yang,7 Yun Duan,7 Huifang Hou,1 Xinyuan Wang,1 Zhimei Yang,1 Xiaoying Wang,1 Shanze Chen,1 Yi Wang,1 Ning Huang,1 Junli Chen1 ...
Li Z, Li J, Liu L, Deng W, Liu Q, Liu R, Zhang W, He Z, Fan L, Yang Y, Duan Y, Hou H, Wang X, Yang Z, Wang X, Chen S, Wang Y, Huang N, Chen J   +18 more
doaj  

Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties [PDF]

, 2020
Chibale, Kelly, Combrinck, Jill, D'hooghe, Matthias, Minić, Aleksandra, Smith, Peter J., Van de Walle, Tim, Van Hecke, Kristof   +6 more
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Safety, tolerability, and efficacy of high versus low-dose, short versus long-course daily primaquine for the radical cure of uncomplicated Plasmodium vivax malaria in children under 15 years of age: an open-label, non-inferiority, randomized controlled trial (CHILDPRIM)

Malaria Journal
Background Primaquine (PQ) is widely used to prevent Plasmodium vivax relapses. However, the most efficacious and safest dose is unknown, particularly in children.
Ana Luisa O. Pacheco, Aretha G. Omena, Djane C. Baía-da-Silva, Tyane A. P. Jardim, Debora C. B. Silva, Adriana P. B. Lopes, Laila R. A. Barbosa, Ingrid G. Souza, Renata F. Araujo, Luis O. S. Nogueira, Suianne C. N. Vale, Gisely C. Melo, Jady S. M. Cordeiro, Quique Bassat, Vanderson S. Sampaio, Valéria D. S. Lima, Flor E. Martinez-Espinosa, Maria Paula G. Mourão, Wuelton M. Monteiro, Maria Graças C. Alecrim, Jose Diego Brito-Sousa, Marcus V. G. Lacerda   +21 more
doaj   +1 more source

Pharmacology of 8-aminoquinolines.

Bulletin of the World Health Organization, 1982
The 8-aminoquinolines were the first group of compounds to be synthesized specifically for their antimalarial activity. A large-scale research programme in the United States of America in the 1940s produced three new antimalarial drugs-pentaquine, isopentaquine, and primaquine -of which primaquine was the most effective.
openaire   +1 more source

Effect of Single Dose of Minocycline on a Chloroquine Resistant Falciparum Infection From Balikpapan, Kalimantan [PDF]

, 1975
Selain 3 kasus P. falciparum yang resistent terhadap chloroquine dari Samarinda (Verdrager & Arwati, 1974) baru-baru ini ditemukan lagi satu kasus juga dari Kalimantan Timur, tetapi dari daerah yang lain (Balikpapan). Terhadap kasus yang terakhir ini
Arwati, A. (Arwati), Verdrager, J. (J)
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