Results 81 to 90 of about 6,120 (213)
Future Journal of Pharmaceutical Sciences, 2020 Background Based on bioisosteric similarities with thiacetazone, a series of 7-chloro-4-aminoquinoline derivatives have been designed and synthesized. The target compounds were elucidated by NMR, mass, and FTIR spectral data.
Shankar Alegaon +7 more
doaj +1 more source
Saquinavir Inhibits the malaria parasite's chloroquine resistance transporter [PDF]
, 2012 The antiretroviral protease inhibitors (APIs) ritonavir, saquinavir, and lopinavir, used to treat HIV infection, inhibit the growth of Plasmodium falciparum at clinically relevant concentrations.
Alice S. Butterworth +43 more
core +1 more source
Comparison of the susceptibility of Plasmodium knowlesi and Plasmodium falciparum to antimalarial agents. [PDF]
, 2017 BACKGROUND: The simian malaria parasite Plasmodium knowlesi is now a well-recognized pathogen of humans in South-East Asia. Clinical infections appear adequately treated with existing drug regimens, but the evidence base for this practice remains weak ...
Blasco, Benjamin +3 more
core +1 more source
Antiproliferative evaluation of various aminoquinoline derivatives
Acta Pharmaceutica, 2019 Abstract Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were ...
Zorc, Branka +2 more
openaire +4 more sources
European Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.A sustainable, ligand‐free Pd‐catalyzed borrowing hydrogen protocol in a biodegradable hydrophobic natural deep eutectic solvent (NADES) (thymol/DL‐menthol) enables the N‐alkylation of primary amines with benzylic alcohols under mild, aerobic conditions, allowing efficient reuse of both catalyst and solvent for seven consecutive cycles. The hydrophobic
Maryam Saeb +5 more
wiley +1 more source
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines [PDF]
, 2015 We have synthesized a series of dimers of (+)-(7R,11R)-huprine Y and evaluated their activity against Trypanosoma brucei, Plasmodium falciparum, rat myoblast L6 cells and human acetylcholinesterase (hAChE), and their brain permeability.
Artigas, Albert +8 more
core +2 more sources
In vitro activity of immunosuppressive drugs against Plasmodium falciparum [PDF]
, 2014 Background Solid organ transplant recipients are particularly vulnerable for infectious diseases due to prolonged immunosuppressive treatment. Residents of endemic regions and travellers may be exposed to malaria and may, therefore, require prolonged ...
Felix Loetsch +6 more
core +2 more sources
Pharmaceuticals, 2010 Drugs that kill or inhibit the sexual stages of Plasmodium could potentially amplify or synergize the impact of other interventions by blocking transmission to mosquitoes.
Anthony E. Kiszewski
doaj +1 more source
Malaria Journal, 2020 Background Trials to assess the efficacy of the radical cure of Plasmodium vivax malaria with 8-aminoquinolines require that most post-treatment relapses are identified, but there is no consensus on the optimal duration of follow-up in either symptomatic
Koukeo Phommasone +18 more
doaj +1 more source
Amodiaquine failure associated with erythrocytic glutathione in Plasmodium falciparum malaria [PDF]
, 2007 Objective To establish the relationship between production of glutathione and the therapeutic response to amodiaquine (AQ) monotherapy in Plasmodium falciparum non-complicated malaria patients.
Lina Zuluaga +4 more
core +1 more source