The role of anti-malarial drugs in eliminating malaria [PDF]
Malaria Journal, 2008 Effective anti-malarial drug treatment reduces malaria transmission. This alone can reduce the incidence and prevalence of malaria, although the effects are greater in areas of low transmission where a greater proportion of the infectious reservoir is ...
White Nicholas J
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Enantioselective Interactions of Anti-Infective 8-Aminoquinoline Therapeutics with Human Monoamine Oxidases A and B [PDF]
Pharmaceuticals, 2021 8-Aminoquinolines (8-AQs) are an important class of anti-infective therapeutics. The monoamine oxidases (MAOs) play a key role in metabolism of 8-AQs. A major role for MAO-A in metabolism of primaquine (PQ), the prototypical 8-AQ antimalarial, has been ...
Narayan D. Chaurasiya +5 more
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Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria
Tropical Medicine and Infectious Disease, 2023 Enhanced therapeutic efficacy achieved in treating Plasmodium vivax malaria with an 8-aminoquinoline (8-AQ) drug such as primaquine (PQ) together with a partner drug such as chloroquine (CQ) is usually explained as CQ inhibiting asexual parasites in the ...
Miles B. Markus
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8-Amino-6-Methoxyquinoline—Tetrazole Hybrids: Impact of Linkers on Antiplasmodial Activity
Molecules, 2021 A new series of compounds was prepared from 6-methoxyquinolin-8-amine or its N-(2-aminoethyl) analogue via Ugi-azide reaction. Their linkers between the quinoline and the tert-butyltetrazole moieties differ in chain length, basicity and substitution ...
Patrick Hochegger +6 more
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Anti‐malarial drug effects on parasite dynamics in vivax malaria
Malaria Journal, 2021 Relapses of Plasmodium vivax malaria are prevented by 8-aminoquinolines. If hypnozoites survive, then the subsequent blood stage infections in early relapses (
Nicholas J. White
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Catalyst controlled remote CH activation of 8-aminoquinolines with NFSI for CN versus CF coupling
Catalysis Communications, 2021 A catalyst-controlled selective functionalization of 8-aminoquinolines with N-fluorobenzenesulfonimide (NFSI) has been developed. The use of GTP-Cu catalysts leads to CN coupling products and whereas the CF coupling reaction is dominant for GPT-Ni ...
Kai Zheng +6 more
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Primaquine for Plasmodium vivax radical cure: What we do not know and why it matters
International Journal for Parasitology: Drugs and Drug Resistance, 2021 Plasmodium vivax radical cure requires the administration of a blood schizonticide for killing blood-stage parasites and the addition of a drug able to kill hypnozoites, the dormant parasite stages residing in the liver of infected patients.
Jean Popovici +3 more
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Frontiers in Pharmacology, 2022 Background:Plasmodium vivax remains the malaria species posing a major threat to human health worldwide owing to its relapse mechanism. Currently, the only drugs of choice for radical cure are the 8-aminoquinolines (primaquine and tafenoquine), which are
Sirapapha Sudsumrit +8 more
doaj +1 more source
Pathogens, 2023 Plasmodium vivax malaria continues to cause a significant burden of disease in the Asia-Pacific, the Horn of Africa, and the Americas. In addition to schizontocidal treatment, the 8-aminoquinoline drugs are crucial for the complete removal of the ...
Arkasha Sadhewa +7 more
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Submicroscopic carriage of Plasmodium falciparum and Plasmodium vivax in a low endemic area in Ethiopia where no parasitaemia was detected by microscopy or rapid diagnostic test. [PDF]
, 2015 BACKGROUND: Motivated by the success in malaria control that was documented over the last decade Ethiopia is aiming at malaria elimination by 2020 in selected districts.
Baidjoe, Amrish +9 more
core +12 more sources