Results 41 to 50 of about 1,092 (179)

Regiodivergent C3 and C4 Amination of Quinolines via Radical and Ionic Pathways

Angewandte Chemie, Volume 138, Issue 16, 13 April 2026.
A regiodivergent strategy converts a single N‐aminoquinolinium precursor into either C3‐ or C4‐aminated quinolines. Nucleophile‐induced dearomatization diverges into light‐driven N‐centered radical capture (C3) or base‐promoted SNAr (C4), enabling rapid assembly of aminoquinoline libraries and late‐stage diversification.
Ye‐Eun Kim, Jieun Kim, Juyeon Lee, Sungwoo Hong   +3 more
wiley   +2 more sources

A pharmacokinetic–pharmacodynamic model for chemoprotective agents against malaria

CPT: Pharmacometrics & Systems Pharmacology, 2023
Chemoprophylactics are a vital tool in the fight against malaria. They can be used to protect populations at risk, such as children younger than the age of 5 in areas of seasonal malaria transmission or pregnant women.
Mohammed H. Cherkaoui‐Rbati, Nicole Andenmatten, Lydia Burgert, Oluwaseun F. Egbelowo, Rolf Fendel, Chiara Fornari, Michael Gabel, John Ward, Jörg J. Möhrle, Nathalie Gobeau   +9 more
doaj   +1 more source

Haemolysis in G6PD Heterozygous Females Treated with Primaquine for Plasmodium vivax Malaria: A Nested Cohort in a Trial of Radical Curative Regimens.

PLoS Medicine, 2017
BackgroundRadical cure of Plasmodium vivax malaria with 8-aminoquinolines (primaquine or tafenoquine) is complicated by haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Cindy S Chu, Germana Bancone, Kerryn A Moore, Htun Htun Win, Niramon Thitipanawan, Christina Po, Nongnud Chowwiwat, Rattanaporn Raksapraidee, Pornpimon Wilairisak, Aung Pyae Phyo, Lily Keereecharoen, Stéphane Proux, Prakaykaew Charunwatthana, François Nosten, Nicholas J White   +14 more
doaj   +1 more source

Optimizing G6PD testing for Plasmodium vivax case management and beyond: why sex, counseling, and community engagement matter [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Safe access to the most effective treatment options for Plasmodium vivax malaria are limited by the absence of accurate point-of-care testing to detect glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common human genetic disorder.
Cindy S Chu, Germana Bancone, Maureen Kelley, Nicole Advani, Gonzalo J Domingo, Eva M Cutiongo-de la Paz, Nicole van der Merwe, Jessica Cohen, Emily Gerth-Guyette   +8 more
doaj   +1 more source

Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application

European Journal of Organic Chemistry, EarlyView.
Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley   +1 more source

Validation of the quantitative point-of-care CareStart biosensor for assessment of G6PD activity in venous blood. [PDF]

PLoS ONE, 2018
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in the human population affecting an estimated 8% of the world population, especially those living in areas of past and present malaria endemicity.
Germana Bancone, Gornpan Gornsawun, Cindy S Chu, Pen Porn, Sampa Pal, Pooja Bansil, Gonzalo J Domingo, Francois Nosten   +7 more
doaj   +1 more source

Real-life implementation of a G6PD deficiency screening qualitative test into routine vivax malaria diagnostic units in the Brazilian Amazon (SAFEPRIM study).

PLoS Neglected Tropical Diseases, 2021
BackgroundGlucose-6-phosphate dehydrogenase (G6PD) deficiency greatly hinders Plasmodium vivax malaria radical cure and further elimination due to 8-aminoquinolines-associated hemolysis.
Jose Diego Brito-Sousa, Felipe Murta, Sheila Vitor-Silva, Vanderson S Sampaio, Maxwell O Mendes, Marcelo A M Brito, Talita S B Batista, Alicia P C Santos, Leonardo L G Marques, Laila R A Barbosa, Marly M Melo, Djane C Baia-da-Silva, Alexandre V Silva-Neto, Thalie C Santos, Brenda K A Souza, Erick F G Figueiredo, Emanuelle L Silva, Sheila Rodovalho, Theresa H Nakagawa, Ana Ruth Arcanjo, André M Siqueira, Gisely C Melo, Judith Recht, Gonzalo J Domingo, Quique Bassat, Germana Bancone, Wuelton M Monteiro, Marcus V G Lacerda   +27 more
doaj   +1 more source

SYNTHESIS OF 8-AMINOQUINOLINES. PART VII

, 1957
Synthesis of 7-chioro-2-methyl-8-amino-4-(4’-hydroxy-3'-diethylaminomethyl)-anilinoquinaldine has been described.
ACHINTYA K. SEN, U. P. BASU
openaire   +1 more source

Chan–Lam Cross‐Coupling With Alkylboron Reagents: From Transmetallation to Radical Pathways

European Journal of Organic Chemistry, EarlyView.
Alkylative Chan–Lam coupling overcomes intrinsic transmetallation limitations of alkylboron reagents by engaging radical pathways. Recent advances reveal how radical and radical–polar crossover mechanisms enable mild C(sp3)—heteroatom bond formation. This minireview highlights key mechanistic insights and emerging strategies that transform alkylboron ...
Nicolas G.‐Simonian, Andrea Serafino, Luc Neuville, Géraldine Masson   +3 more
wiley   +1 more source

Optimizing G6PD testing for Plasmodium vivax case management: why sex, counseling, and community engagement matter [version 1; peer review: 2 approved]

Wellcome Open Research, 2020
Safe access to the most effective treatment options for Plasmodium vivax malaria are limited by the absence of accurate point-of-care testing to detect glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common human genetic disorder.
Cindy S Chu, Germana Bancone, Maureen Kelley, Nicole Advani, Gonzalo J Domingo, Eva M Cutiongo-de la Paz, Nicole van der Merwe, Jessica Cohen, Emily Gerth-Guyette   +8 more
doaj   +1 more source