Results 31 to 40 of about 1,092 (179)

Synthesis and antiplasmodial activity of regioisomers and epimers of second-generation dual acting ivermectin hybrids

Scientific Reports, 2022
With its strong effect on vector-borne diseases, and insecticidal effect on mosquito vectors of malaria, inhibition of sporogonic and blood-stage development of Plasmodium falciparum, as well as in vitro and in vivo impairment of the P.
Lovepreet Singh, Diana Fontinha, Denise Francisco, Miguel Prudêncio, Kamaljit Singh   +4 more
doaj   +1 more source

The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR

Malaria Journal, 2020
Background Trials to assess the efficacy of the radical cure of Plasmodium vivax malaria with 8-aminoquinolines require that most post-treatment relapses are identified, but there is no consensus on the optimal duration of follow-up in either symptomatic
Koukeo Phommasone, Frank van Leth, Mallika Imwong, Gisela Henriques, Tiengkham Pongvongsa, Bipin Adhikari, Thomas J. Peto, Cholrawee Promnarate, Mehul Dhorda, Pasathorn Sirithiranont, Mavuto Mukaka, Pimnara Peerawaranun, Nicholas P. J. Day, Frank Cobelens, Arjen M. Dondorp, Paul N. Newton, Nicholas J. White, Lorenz von Seidlein, Mayfong Mayxay   +18 more
doaj   +1 more source

Antimalarial and antimicrobial activities of 8-aminoquinoline-uracils metal complexes [PDF]

, 2016
8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and ...
Kunwittaya, Sarun, Phopin, Kamonrat, Prachayasittikul, Supaluk, Prachayasittikul, Virapong, Ruchirawat, Somsak, Sinthupoom, Nujarin, Treeratanapiboon, Lertyot   +6 more
core   +1 more source

Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids [PDF]

, 2020
This is the pre-peer reviewed version of the following article: Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids, which has been published in final form at https://doi.org/10.1002/slct.201903835.
Carda, Miguel, Cardona G, Wilson I, Coa, Juan Carlos, Conesa Milián, Laura, Robledo, Sara M., Upegui Zapata, Yulieth Alexandra, Yepes, Andrés   +6 more
core   +1 more source

Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials

Pharmaceuticals, 2010
Drugs that kill or inhibit the sexual stages of Plasmodium could potentially amplify or synergize the impact of other interventions by blocking transmission to mosquitoes.
Anthony E. Kiszewski
doaj   +1 more source

In silico modeling of tetraoxane-8-aminoquinoline hybrids active against Plasmodium falciparum

Beni-Suef University Journal of Basic and Applied Sciences, 2020
Background Quantitative structure-activity relationships (QSAR) is a technique that is used to produce a model that connects biological activities of compounds to their chemical structures, and molecular docking is a technique that reveals the binding ...
Aliyu Wappah Mahmud, Gideon Adamu Shallangwa, Adamu Uzairu   +2 more
doaj   +1 more source

Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers [PDF]

, 2016
Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria.
Bandara Herath, H. M. T., Baresel, Paul, Bartlett, Marilyn S., Dhammika Nanayakkara, N. P., Fronczek, Frank R., Gettayacamin, Montip, McChesney, James D., Melendez, Victor, Ohrt, Colin, Reichard, Gregory A., Rochford, Rosemary, Sahu, Rajnish, Tekwani, Babu L., Tungtaeng, Anchalee, Van Gessel, Yvonne, Walker, Larry A., Wickham, Kristina S.   +16 more
core   +1 more source

The blood schizonticidal activity of tafenoquine makes an essential contribution to its prophylactic efficacy in nonimmune subjects at the intended dose (200 mg)

Malaria Journal, 2017
Tafenoquine (TQ) is an 8-aminoquinoline anti-malarial being developed for malaria prophylaxis. It has been generally assumed that TQ, administered prophylactically, acts primarily on the developing exoerythrocytic stages of malaria parasites (causal ...
Geoffrey Dow, Bryan Smith
doaj   +1 more source

Peptidomimetic and Organometallic Derivatives of Primaquine Active against Leishmania infantum [PDF]

, 2012
The current treatment of visceral leishmaniasis is made difficult by the low efficacy, elevated costs, low bioavailability, and high toxicity of many of the available drugs.
Ana Tomas, Joana Matos, Maria Salome Gomes, Nuno Vale, Paula Gomes, Rui Moreira, Silvia Vale Costa   +6 more
core   +1 more source

Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines

Malaria Journal, 2018
Background Tafenoquine was recently approved for Plasmodium vivax radical cure (KRINTAFEL™) and malaria prevention (ARAKODA™). Methods A review of the non-clinical and clinical literature was conducted to assess whether tafenoquine (and primaquine ...
Jonathan Berman, Tracey Brown, Geoffrey Dow, Stephen Toovey   +3 more
doaj   +1 more source