Results 11 to 20 of about 1,092 (179)

G6PD deficiency in malaria endemic areas of Nepal

Malaria Journal, 2020
Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is currently a threat to malaria elimination due to risk of primaquine-induced haemolysis in G6PD deficient individuals.
Baburam Marasini, Bibek Kumar Lal, Suman Thapa, Kiran Raj Awasthi, Bijay Bajracharya, Pratik Khanal, Sanjeev Neupane, Shambhu Nath Jha, Sanjaya Acharya, Smriti Iama, Madan Koirala, Dinesh Koirala, Suresh Bhandari, Ram Kumar Mahato, Arun Chaudhary, Pramin Ghimire, Rahachan Gharti Magar, Rajan Kumar Bhattarai, Gornpan Gornsawun, Pimsupah Penpitchaporn, Germana Bancone, Bhim Prasad Acharya   +21 more
doaj   +1 more source

Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion

Malaria Journal, 2019
Background Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites.
Germana Bancone, Didier Menard, Nimol Khim, Saorin Kim, Lydie Canier, Chea Nguong, Koukeo Phommasone, Mayfong Mayxay, Sabine Dittrich, Malavanh Vongsouvath, Nadine Fievet, Jean-Yves Le Hesran, Valerie Briand, Sommay Keomany, Paul N. Newton, Gornpan Gorsawun, Kaelan Tardy, Cindy S. Chu, Orpreeya Rattanapalroj, Le Thanh Dong, Huynh Hong Quang, Nguyen Tam-Uyen, Nguyen Thuy-Nhien, Tran Tinh Hien, Michael Kalnoky, Francois Nosten   +25 more
doaj   +1 more source

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. [PDF]

, 2014
Preventing relapses of Plasmodium vivax malaria through a radical cure depends on use of the 8-aminoquinoline primaquine, which is associated with safety and compliance issues.
Borboa, Rachel, Campo, Brice, Chatterjee, Arnab K, Chen, Zhong, Diagana, Thierry T, Gagaring, Kerstin, Glynne, Richard J, Klooster, Els J, Kocken, Clemens HM, Kuhen, Kelli, Leroy, Didier, Luty, Adrian, McNamara, Case W, Nagle, Advait, Plouffe, David M, Remarque, Edmond J, Roland, Jason, Sauerwein, Robert, Thomas, Alan W, van Amsterdam, Sandra M, van den Berg, Alexander, van Gemert, Geert-Jan, Voorberg-van der Wel, Annemarie, Winzeler, Elizabeth A, Yeung, Bryan KS, Zeeman, Anne-Marie   +25 more
core   +1 more source

Heterogeneity of G6PD deficiency prevalence in Mozambique: a school-based cross-sectional survey in three different regions [PDF]

, 2017
Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked hereditary enzymatic abnormality that affects more than 400 million people worldwide.
Aide, Pedro Carlos Paulino, Alonso, Pedro, Bassat Orellana, Quique, Galatas, Beatriz, Mabote, Lurdes, Macete, Eusebio Víctor, Matambisso, Gloria, Mañú Pereira, María del Mar, Menéndez, Clara, Nhamussua, Lidia, Saute, Francisco, Simone, Wilson   +11 more
core   +4 more sources

Primaquine-induced haemolysis in females heterozygous for G6PD deficiency

Malaria Journal, 2018
Oxidative agents can cause acute haemolytic anaemia in persons with G6PD deficiency. Understanding the relationship between G6PD genotype and the phenotypic expression of the enzyme deficiency is necessary so that severe haemolysis can be avoided.
Cindy S. Chu, Germana Bancone, François Nosten, Nicholas J. White, Lucio Luzzatto   +4 more
doaj   +1 more source

4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease

Pharmaceutics, 2022
Considering that acetylcholinesterase (AChE) inhibition is the most important mode of action expected of a potential drug used for the treatment of symptoms of Alzheimer’s disease (AD), our previous pilot study of 4-aminoquinolines as potential human ...
Katarina Komatović, Ana Matošević, Nataša Terzić-Jovanović, Suzana Žunec, Sandra Šegan, Mario Zlatović, Nikola Maraković, Anita Bosak, Dejan M. Opsenica   +8 more
doaj   +1 more source

A first example of cobalt-catalyzed remote C-H functionalization of 8-aminoquinolines operating through a single electron transfer mechanism [PDF]

, 2016
The development of new C[BOND]H functionalization protocols based on inexpensive cobalt catalysts is currently attracting significant interest. Functionalized 8-aminoquinoline compounds are high-potential building blocks in organic chemistry and ...
Ackermann, Cong, Corbet, Donaldson, Dong, Fors, Galliker, Gandy, Goldstein, Grossi, Guo, Guo, He, Hong, Hu, Iwai, Katayev, Kilpatrick, Kochi, Koley, Liang, Liu, Liu, Maity, Moselage, Nakata, Olah, Ono, Planas, Qiao, Recht, Sahoo, Saito, Seuss, Taniguchi, Wang, Wei, Wei, Williams, Xia, Xu, Yan, Yan, Yoon, Zhang, Zhang, Zhang, Zhao, Zhou, Zhu   +49 more
core   +1 more source

Nopol-Based Quinoline Derivatives as Antiplasmodial Agents

Molecules, 2021
Malaria remains a significant cause of morbidity and mortality in Sub-Saharan Africa and South Asia. While clinical antimalarials are efficacious when administered according to local guidelines, resistance to every class of antimalarials is a persistent ...
Rogers J. Nyamwihura, Huaisheng Zhang, Jasmine T. Collins, Olamide Crown, Ifedayo Victor Ogungbe   +4 more
doaj   +1 more source

Review of mass drug administration for malaria and its operational challenges. [PDF]

, 2015
Mass drug administration (MDA) was a component of many malaria programs during the eradication era, but later was seldomly deployed due to concerns regarding efficacy and feasibility and fear of accelerating drug resistance.
Chen, Ingrid, Gosling, Roly, Greenwood, Brian, Hwang, Jimee, Ippolito, Matthew M, Kachur, S Patrick, Koita, Kadiatou, Newby, Gretchen, Poirot, Eugenie, Shanks, G Dennis, Slutsker, Laurence, von Seidlein, Lorenz, Wegbreit, Jennifer   +12 more
core   +1 more source

Arylmethylamino steroids as antiparasitic agents [PDF]

, 2017
In search of antiparasitic agents, we here identify arylmethylamino steroids as potent compounds and characterize more than 60 derivatives. The lead compound 1o is fast acting and highly active against intraerythrocytic stages of chloroquine-sensitive ...
Becker, Katja, Beckmann, Svenja, Blandin, Stéphanie, Brakhage, Axel, Burrows, Jeremy, Dahse, Hans-Martin, Davioud-Charvet, Elisabeth, Elhabiri, Mourad, Goetz, Alice-Anne, Grevelding, Christoph G., Jortzik, Esther, Krieg, Reimar, Nuryyeva, Selbi, Pinkerton, Anthony B., Quack, Thomas, Rahbari, Mahsa, Rahlfs, Stefan, Schönecker, Bruno, Voigt, Kerstin, Wittlin, Sergio   +19 more
core   +11 more sources