Results 21 to 30 of about 1,092 (179)
Recent developments in 8-aminoquinoline antimalarials [PDF]
, 1984 Malaria is an old scourge of mankind and mention of the disease is found in ancient writings in India, Egypt and China [1]. The clinical symptoms of this disease were described by Hippocrates 400 years before the Christian era [1]. Human population affected by malaria is alarmingly large in tropical regions although in the past the disease was also ...
B K, Bhat, M, Seth, A P, Bhaduri
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Cu(II) and Fe(III) complexes of sulphadoxine mixed with pyramethamine: Synthesis, characterization, antimicrobial and toxicology study [PDF]
, 2012 Two new mixed ligands metal complexes of sulphadoxine and pyramethamine were prepared by using CuCl2.6H2O and FeCl3.6H2O. The complexes were characterized by elemental analysis, melting point determination, molar conductivity, metal content analysis (AAS)
Adekoya, J. A. +5 more
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Wide range of G6PD activities found among ethnic groups of the Chittagong Hill Tracts, Bangladesh.
PLoS Neglected Tropical Diseases, 2020 The proportion of Plasmodium vivax malaria among all malarias is increasing worldwide. Treatment with 8-aminoquinolines remain the only radical cure.
Benedikt Ley +12 more
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8-Aminoquinoline Therapy for Latent Malaria [PDF]
Clinical Microbiology Reviews, 2019 The technical genesis and practice of 8-aminoquinoline therapy of latent malaria offer singular scientific, clinical, and public health insights. The 8-aminoquinolines brought revolutionary scientific discoveries, dogmatic practices, benign neglect, and, finally, enduring promise against endemic malaria.
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Life Science Alliance, 2022 Infusions from two Artemisia species, one containing artemisinin, the other not, equally inhibit pre-erythrocytic and erythrocytic stages of different Plasmodium species, including two relapsing species.
Kutub Ashraf +18 more
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Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones [PDF]
, 2008 A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P.
Jiri Gut +7 more
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A Guide to Directing Group Removal: 8‐Aminoquinoline
Chemistry – A European Journal, 2021 AbstractThe use of directing groups allows high levels of selectivity to be achieved in transition metal‐catalyzed transformations. Efficient removal of these auxiliaries after successful functionalization, however, can be very challenging. This review provides a critical overview of strategies used for removal of Daugulis’ 8‐aminoquinoline (2005–2020),
Liam S. Fitzgerald, Miriam L. O'Duill
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Malaria Journal, 2018 Background The study aimed to gain first data on the prevalence of G6PD enzyme deficiency measured by spectrophotometry and associated genetic variants in Jimma and surroundings, Ethiopia.
Nora Kießling +9 more
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G6PD Variants and Haemolytic Sensitivity to Primaquine and Other Drugs
Frontiers in Pharmacology, 2021 Restrictions on the cultivation and ingestion of fava beans were first reported as early as the fifth century BC. Not until the late 19th century were clinical descriptions of fava-induced disease reported and soon after characterised as “favism” in the ...
Germana Bancone +3 more
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Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria. [PDF]
PLoS Neglected Tropical Diseases, 2018 The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with
James Watson +5 more
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