Results 61 to 70 of about 1,092 (179)

Polycationic Peptides That Bind T‐Box Riboswitch Antiterminator RNA and Inhibit Riboswitch Function

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
Polycationic decapeptides inhibit T‐box riboswitch tRNA‐induced transcription readthrough. ABSTRACT Resistance to antibiotic treatments continues to be a significant health challenge and necessitates investigating novel antibacterial targets including noncoding regulatory RNA.
Emily Fairchild, Danushika Herath, Sebastian Lux, Sophie R. Harvey, Deborah Amesaki, Destini McCartney, Monique Richter, Ralf Hoffmann, Jennifer V. Hines   +8 more
wiley   +1 more source

Vivax malaria in pregnancy and lactation: a long way to health equity

Malaria Journal, 2020
Background The Sustainable Development Goals (SDG) call for increased gender equity and reduction in malaria-related mortality and morbidity. Plasmodium vivax infections in pregnancy are associated with maternal anaemia and increased adverse perinatal ...
Tobias Brummaier, Mary Ellen Gilder, Gornpan Gornsawun, Cindy S. Chu, Germana Bancone, Mupawjay Pimanpanarak, Kesinee Chotivanich, François Nosten, Rose McGready   +8 more
doaj   +1 more source

Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening [PDF]

, 2023
The sporozoite stages of malaria parasites are the primary cause of infection of the vertebrate host and are targeted by (experimental) vaccines. Yet, little is known about their susceptibility to chemical intervention. Phenotypic high-throughput screens
Bolscher, Judith M, Campo, Brice, Chen, Emily, de Bruijni, Marloes, Dechering, Koen J, Gray, David, Kiczun, Michael, Koolen, Karin J M, Miglianico, Marie, Rajagopal, Deeya S, Sauerwein, Robert W, Vos, Martijn W   +11 more
core   +2 more sources

Tomato Spotted Wilt Virus Reprogrammes Host Glycolysis to Facilitate Proliferation by a Phase‐Separated Co‐Aggregate of Nucleocapsid Protein and Phosphoglycerate Kinase

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2826-2842, May 2026.
ABSTRACT Efficient viral proliferation within the host is a critical step in pathogenicity and requires adenosine triphosphate (ATP). The replication, movement and immune evasion of many plant viruses within their hosts are associated with phase separation (PS)‐derived aggregates formed by viral components.
Guangcheng Zu, Zhifu Xing, Jiao Li, Tangbing Yang, Huan Wu, Qiangsheng Ge, Yanju Wang, Baoan Song, Runjiang Song   +8 more
wiley   +1 more source

Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Hartono Candra, Xue‐Jiao Wang, Ka Diam Go, Li Feng, Miaomiao Cai, Guang‐Lei Ma, Clarissa Widyantoro, Lik Tong Tan, Zbynek Bozdech, Zhe Wang, Zhao‐Xun Liang   +10 more
wiley   +1 more source

Genetic analysis and molecular basis of G6PD deficiency among malaria patients in Thailand: implications for safe use of 8-aminoquinolines

Malaria Journal
Background It was hypothesized that glucose-6-phosphate dehydrogenase (G6PD) deficiency confers a protective effect against malaria infection, however, safety concerns have been raised regarding haemolytic toxicity caused by radical cure with 8 ...
Usa Boonyuen, Beatriz Aira C. Jacob, Jutamas Wongwigkan, Kamonwan Chamchoy, Natsamon Singha-art, Natnicha Pengsuk, Duantida Songdej, Emily R. Adams, Thomas Edwards, Supat Chamnanchanunt, Syazwani Itri Amran, Nurriza Ab Latif, Naveen Eugene Louis, Shamini Chandran   +13 more
doaj   +1 more source

Characterization of G6PD genotypes and phenotypes on the northwestern Thailand-Myanmar border.

PLoS ONE, 2014
Mutations in the glucose-6-phosphate dehydrogenase (G6PD) gene result in red blood cells with increased susceptibility to oxidative damage. Significant haemolysis can be caused by primaquine and other 8-aminoquinoline antimalarials used for the radical ...
Germana Bancone, Cindy S Chu, Raweewan Somsakchaicharoen, Nongnud Chowwiwat, Daniel M Parker, Prakaykaew Charunwatthana, Nicholas J White, François H Nosten   +7 more
doaj   +1 more source

Clinical Laboratory Parameters Among Adult Males During a Primaquine Chemoprophylaxis Trial in Irian Jaya, Indonesia [PDF]

, 1995
Primakuin yang digunakan sebagai profilaksis malaria terbukti efektif dan diterima dengan baik oleh tubuh manusia yang normal terhadap aktivitas enzim 6 glukosa-6 fosfat dehidrogenase (G-6PD).
Baird, J. K. (J), Fryauff, D. J. (David), Hadiputranto, H. (Hilda), Hoffman, S. L. (Stephen), Larasati, R. P. (Ria), Mouzin, E. (Eric), Pudjoprawoto, N. (Nurani), Ratiwayanto, S. (Sutanti), Richards, A. L. (Allen), Richie, T. L. (Thomas), Sandjaya, B. (Bartolomeus), Subianto, B. (Budi), Sutamihardja, M. A. (Mochammad), Tjitra, E. (Emiliana), Wignall, F. S. (F)   +14 more
core  

: who cares? [PDF]

, 2008
More attention is being focused on malaria today than any time since the world's last efforts to achieve eradication over 40 years ago. The global community is now discussing strategies aimed at dramatically reducing malarial disease burden and the ...
Mary R Galinski, John W Barnwell
core   +1 more source

A Sustainable Borrowing Hydrogen Strategy in Natural Deep Eutectic Solvents for the N‐Alkylation of Amines From Alcohols

European Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.
A sustainable, ligand‐free Pd‐catalyzed borrowing hydrogen protocol in a biodegradable hydrophobic natural deep eutectic solvent (NADES) (thymol/DL‐menthol) enables the N‐alkylation of primary amines with benzylic alcohols under mild, aerobic conditions, allowing efficient reuse of both catalyst and solvent for seven consecutive cycles. The hydrophobic
Maryam Saeb, Maristella Simone, Luciana Cicco, Paola Vitale, Filippo Maria Perna, Vito Capriati   +5 more
wiley   +1 more source