Results 71 to 80 of about 1,092 (179)

Reference and point-of-care testing for G6PD deficiency: Blood disorder interference, contrived specimens, and fingerstick equivalence and precision.

PLoS ONE, 2021
Certain clinical indications and treatments such as the use of rasburicase in cancer therapy and 8-aminoquinolines for Plasmodium vivax malaria treatment would benefit from a point-of-care test for glucose-6-phosphate dehydrogenase (G6PD) deficiency ...
Sampa Pal, Jane Myburgh, Pooja Bansil, Amanda Hann, Lynn Robertson, Emily Gerth-Guyette, Gwen Ambler, Greg Bizilj, Maria Kahn, Stephanie Zobrist, Michelle R Manis, Nickolas A Styke, Vajra Allan, Richard Ansbro, Tobi Akingbade, Andrew Bryan, Sean C Murphy, James G Kublin, Mark Layton, Gonzalo J Domingo   +19 more
doaj   +1 more source

Antimalarial activity of the anticancer histone deacetylase inhibitor SB939 [PDF]

, 2012
Histone deacetylase (HDAC) enzymes posttranslationally modify lysines on histone and nonhistone proteins and play crucial roles in epigenetic regulation and other important cellular processes. HDAC inhibitors (e.g., suberoylanilide hydroxamic acid [SAHA;
Andrews, Katherine T., Do, Tram Anh, Fairlie, David P., Goodman, Christopher D., Haque, Ashraful, Lucke, Andrew J., McFadden, Geoffrey I., Sahama, Ishani, Skinner-Adams, Tina, Sumanadasa, Subathdrage D. M.   +9 more
core   +1 more source

Macromolecular 4-aminoquinoline compounds as potential antimalarial drugs [PDF]

, 2011
4-Aminoquinolines have a long and successful history as antimalarials as they have provided a number of useful antimalarials. P. falciparum, a causative organism of the most deadly form of human malaria, is generally slow to develop resistance to these ...
Aderibigbe, Atim Blessing
core  

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, Volume 32, Issue 13, 1 April 2026.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Shrinking the Malaria Map: A Prospectus on Malaria Elimination [PDF]

, 2009
\ud Thirty-nine countries across the world are making progress toward malaria elimination. Some are committed to nationwide elimination, while others are pursuing spatially progressive elimination within their borders.
Feachem, Richard G.A., Phillips, Allison A., Targett, Geoff rey A.   +2 more
core   +3 more sources

Pharmacological considerations in the design of anti-malarial drug combination therapies - is matching half-lives enough? [PDF]

, 2014
Anti-malarial drugs are now mainly deployed as combination therapy (CT), primarily as a mechanism to prevent or slow the spread of resistance. This strategy is justified by mathematical arguments that generally assume that drug 'resistance' is a binary ...
Hodel, Eva Maria
core   +1 more source

Choroidal Vascularity Index in Schizophrenia Compared to Healthy Subjects: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims This study aims to evaluate choroidal vascular architecture in patients with schizophrenia compared to healthy individuals. Methods This cross‐sectional study was conducted between 2019 and 2021. In total, 22 hospitalized patients with documented instances of schizophrenia and 22 healthy subjects were included. Demographic,
Mehrdad Motamed Shariati, Maryam Naghib, Marziyeh Fotouhi, Mohammad Reza Fayyazi Bordbar   +3 more
wiley   +1 more source

Variation in Glucose-6-Phosphate Dehydrogenase activity following acute malaria

PLoS Neglected Tropical Diseases, 2022
Primaquine and tafenoquine are the only licensed drugs with activity against Plasmodium vivax hypnozoites but cause haemolysis in patients with glucose–6–phosphate dehydrogenase (G6PD) deficiency.
Benedikt Ley, Mohammad Shafiul Alam, Ari Winasti Satyagraha, Ching Swe Phru, Kamala Thriemer, Dagimawie Tadesse, Tamiru Shibiru, Asrat Hailu, Mohammad Golam Kibria, Mohammad Sharif Hossain, Hisni Rahmat, Jeanne R. Poespoprodjo, Wasif Ali Khan, Julie A. Simpson, Ric N. Price   +14 more
doaj  

The impact of phenotypic and genotypic G6PD deficiency on risk of plasmodium vivax infection: a case-control study amongst Afghan refugees in Pakistan. [PDF]

PLoS Medicine, 2010
BACKGROUND: The most common form of malaria outside Africa, Plasmodium vivax, is more difficult to control than P. falciparum because of the latent liver hypnozoite stage, which causes multiple relapses and provides an infectious reservoir.
Toby Leslie, Marnie Briceño, Ismail Mayan, Nasir Mohammed, Eveline Klinkenberg, Carol Hopkins Sibley, Christopher J M Whitty, Mark Rowland   +7 more
doaj   +1 more source

Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3beta of substituted quinolines. [PDF]

, 2014
A new series of fifteen 5-, 6-, and 8-appended 4-methylquinolines were synthesized and evaluated for their neural protective activities. Selected compounds were further examined for their inhibition of glycogen synthase kinase-3β (GSK-3β) and protein ...
Erenler, Ramazan, Hua, Duy H., Jin, Lee-Way, Li, Jun, Lu, Lu, Maezawa, Izumi, Nguyen, James, Nguyen, Thi D.T., Ranjan, Alok, Srivastava, Sanjay K., Swisher, Luxi Zhang, Weerasekara, Sahani   +11 more
core   +1 more source