Results 61 to 70 of about 6,120 (213)

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Submicroscopic carriage of Plasmodium falciparum and Plasmodium vivax in a low endemic area in Ethiopia where no parasitaemia was detected by microscopy or rapid diagnostic test. [PDF]

, 2015
BACKGROUND: Motivated by the success in malaria control that was documented over the last decade Ethiopia is aiming at malaria elimination by 2020 in selected districts.
Baidjoe, Amrish, Bousema, Teun, Drakeley, Chris, Grignard, Lynn, Hall, Tom, Lanke, Kjerstin, Mamo, Hassen, Pett, Helmi, Sutherland, Colin, Tadesse, Fitsum G   +9 more
core   +4 more sources

Ultrasound‐Assisted Synthesis and Comprehensive Characterization of Nanosized VO(II), Fe(III), and Ru(III) Complexes: From Density Functional Theory/Nonlinear Optical Properties to Pharmaceutical Applications and Docking Insights

ChemistryOpen, Volume 15, Issue 6, June 2026.
Ultrasound‐assisted synthesis enabled the formation of ultrafine hydrazone‐based metal complexes with controlled nanostructures and enhanced stability. Density functional theory revealed optimized geometries and electronic properties. The nanosized complexes exhibited superior antimicrobial, anticancer, and antioxidant activities, supported by ...
R. A. El‐Kasaby, Eida S. Al‐Farraj, Senem Akkoc, Amal H. Alsehli, Maher Fathalla, Samir A. Abdel‐Latif, Mashael A. Alghamdi, Ahmed M. Abu‐Dief   +7 more
wiley   +1 more source

8-Amino-6-Methoxyquinoline—Tetrazole Hybrids: Impact of Linkers on Antiplasmodial Activity

Molecules, 2021
A new series of compounds was prepared from 6-methoxyquinolin-8-amine or its N-(2-aminoethyl) analogue via Ugi-azide reaction. Their linkers between the quinoline and the tert-butyltetrazole moieties differ in chain length, basicity and substitution ...
Patrick Hochegger, Johanna Dolensky, Werner Seebacher, Robert Saf, Marcel Kaiser, Pascal Mäser, Robert Weis   +6 more
doaj   +1 more source

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]

, 2004
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Stepniewska, K, Taylor, W R J, Mayxay, M, Price, R, Smithuis, F, Guthmann, J P, Barnes, K, Myint, H Y, Adjuik, M, Olliaro, P, Pukrittayakamee, S, Looareesuwan, S, Hien, T T, Farrar, J, Nosten, F, Day, N P J, White, N J   +16 more
core   +2 more sources

Chan–Lam Cross‐Coupling With Alkylboron Reagents: From Transmetallation to Radical Pathways

European Journal of Organic Chemistry, Volume 29, Issue 18, 14 May 2026.
Alkylative Chan–Lam coupling overcomes intrinsic transmetallation limitations of alkylboron reagents by engaging radical pathways. Recent advances reveal how radical and radical–polar crossover mechanisms enable mild C(sp3)—heteroatom bond formation. This minireview highlights key mechanistic insights and emerging strategies that transform alkylboron ...
Nicolas G.‐Simonian, Andrea Serafino, Luc Neuville, Géraldine Masson   +3 more
wiley   +1 more source

Metal‐Free, Chemoselective Reduction of Aromatic Nitro Compounds in Water at Room Temperature

ChemistryOpen, Volume 15, Issue 5, May 2026.
A metal‐free, rapid, and chemoselective nitro reduction of aromatic compounds is developed using tetrahydroxydiboron as reducing agent and 4,4′‐bipyridine as organocatalyst. This green method provides an efficient entry to aromatic amines with high functional group tolerance in excellent yields under mild conditions using water as solvent. A metal‐free,
Maria Batzaki, Thomas S. A. Heugebaert, Christian V. Stevens   +2 more
wiley   +1 more source

Functionalized 3-hydroxy-3-aminoquinoline-oxindole hybrids as promising dual-function anti-plasmodials

European Journal of Medicinal Chemistry Reports, 2022
Malaria parasites continue to pose a concern. Drug resistance underlines the need for new structural cores that, when combined with existing antimalarial frameworks, can partially re-sensitize drug-resistant parasites to available antimalarial drugs ...
Bharvi Sharma, Jenny Legac, Nosipho Cele, Paul Awolade, Philip J. Rosenthal, Parvesh Singh, Vipan Kumar   +6 more
doaj   +1 more source

Anti-pneumoscystis carinni activitiy of primaquine imidazolidin-4-ones [PDF]

, 2006
Pneumocystis pneumonia (PCP) is one of the most frequent causes of mortality among HIV-infected patients. Primaquine (PQ) is an antimalarial 8-aminoquinoline effective against PCP when given in combination with clindamycin.
Araújo, Maria João, Azevedo, Joana, Collins, Margaret S., Cushion, Melanie T., Ferraz, Ricardo, Gomes, Paula, Moreira, Rui, Vale, Nuno   +7 more
core  

SERS‐Based Nano‐ and Microsystems Toward Biomedical Applications

Small, Volume 22, Issue 28, 18 May 2026.
This review provides a current overview of nano‐ and microscale SERS‐based devices, encompassing all aspects from material design to practical applications. We highlight controlled SERS‐active architectures, including patterned substrates, nanorods, microspheres, micromotors, and microneedles, as well as combinations of these microfluidic systems.
Gohar Soufi, Tijana Maric, Isidro Badillo‐Ramírez, Juliane Fjelrad Christfort, Matteo Tollemeto, Carmen Milan Guimera, Casper Nisula, Giulia Zappalá, Laura De Vittorio, Marta Rubio‐Huertas, Sungyeong Kim, Ziqiao Li, Morten Bo Søndergaard Svendsen, Zhongyang Zhang, Anja Boisen   +14 more
wiley   +1 more source