Results 41 to 50 of about 23,342 (303)

Transcriptional Regulation of the Genes Encoding Branched-Chain Aminotransferases in Kluyveromyces lactis and Lachancea kluyveri Is Independent of Chromatin Remodeling

Microbiology Research
In yeasts, the Leu3 transcriptional factor regulates the expression of genes encoding enzymes of the leucine biosynthetic pathway, in which the first committed step is catalyzed by α-isopropylmalate synthase (α-IPMS). This enzyme is feedback inhibited by
James González, Héctor Quezada, Jose Carlos Campero-Basaldua, Édgar Ramirez-González, Lina Riego-Ruiz, Alicia González   +5 more
doaj   +1 more source

Optimization of methods for aspartate aminotransferase and alanine aminotransferase.

Clinical Chemistry, 1978
Abstract Conditions for accurate measurement of catalytic activity of aspartate aminotransferase and alanine aminotransferase in human serum have been reinvestigated. The basic variables (kind of buffer, buffer concentration, pH, ion effects, and the influence of pyridoxal-5-phosphate) can now be considered optimized.
H U, Bergmeyer, P, Scheibe, A W, Wahlefeld   +2 more
openaire   +2 more sources

Selective inhibition of alanine aminotransferase and aspartate aminotransferase in rat hepatocytes [PDF]

Biochemical Journal, 1984
Experiments were conducted with intact rat hepatocytes to identify inhibitors and incubation conditions that cause selective inhibition of alanine aminotransferase or aspartate aminotransferase. Satisfactory results were obtained by preincubating cells with L-cycloserine or L-2-amino-4-methoxy-trans-but-3-enoic acid in the absence of added substrates ...
N W, Cornell, P F, Zuurendonk, M J, Kerich, C B, Straight   +3 more
openaire   +2 more sources

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Effect of naringerin on biochemical parameters in the streptozotocin-induced diabetic rats

Brazilian Archives of Biology and Technology, 2009
Amongst the numerous co-adjuvant therapies which could influence the incidence and progression of diabetic complications, antioxidants and flavonoids are currently being tested in clinical trials.
Ana Angélica Henrique Fernandes, Ethel Lourenzi Barbosa Novelli, Ary Fernandes Junior, Cristiano Machado Galhardi   +3 more
doaj   +1 more source

Is It Necessary to Order Aspartate Aminotransferase with Alanine Aminotransferase in Clinical Practice? [PDF]

Clinical Chemistry, 2001
We read with great interest the articles by Dufour et al., “Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests” (1) and “Diagnosis and monitoring of hepatic injury. II. Recommendations for use of laboratory tests in screening, diagnosis, and monitoring” (2).
A, Larsson, N, Tryding
openaire   +2 more sources

Persistence of elevated aminotransferases in Wilson's disease despite adequate therapy

, 2004
The persistence of elevated aminotransferases in Wilson's disease despite adequate therapy is ...
Marazzi, Maria Grazia, Michielutti, Fabio, Vegnente, Angela, D'Ambrosi, Mariangela, Giacchino, Raffaella, Vajro, Pietro, Iorio, Raffaele, Marcellini, Matilde, Resti, Massimo, Maggiore, Giuseppe, Pastore, Maria, Barbera, Christiana, Zancan, Lucia, Frediani, Tullio, Francavilla, Ruggiero   +14 more
core   +1 more source

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

The Interactions between Metallic Nanoparticles and Cytochrome P450, Alanine Aminotransferase, and Aspartate Aminotransferase Enzymes

Journal of Pure and Applied Microbiology, 2023
The use of metallic nanoparticles (NPs) in various industrial and biomedical fields is increasing exponentially. As a result, research examining the potentially toxic impact of these NPs on human health is also increasing. Cytochrome P450 (P450s) enzymes
Hayat A. Al-Btoush
doaj   +1 more source

Photoinactivation of Aspartate Aminotransferase

Journal of Biological Chemistry, 1970
Abstract The cofactor pyridoxal 5'-phosphate bound through an aldimine linkage to lysine residues of the enzyme aspartate aminotransferase is very stable to irradiation with light of 420 nm. The catalytic function of the enzyme exposed to light absorbed by the cofactor remains unaffected, indicating that pyridoxal 5'-phosphate is not an efficient ...
N, Burridge, J E, Churchich
openaire   +2 more sources