Results 21 to 30 of about 23,342 (303)

Assessment of the hepatorenal and hematological parameters of rats exposed to graded doses of lysine acetylsalicylate

open access: yesJournal of Taibah University for Science, 2022
Lysine acetylsalicylate (LAS) is an analgesic used for the prevention of cardiovascular disease with few adverse though its effect on the hepatorenal and hematological parameters remains unclear. 45 mature male Wistar rats were equally divided into three
Ibrahim M. El-Ashmawy   +4 more
doaj   +1 more source

AGXT2: a promiscuous aminotransferase [PDF]

open access: yesTrends in Pharmacological Sciences, 2014
Alanine-glyoxylate aminotransferase 2 (AGXT2) is a multifunctional mitochondrial aminotransferase that was first identified in 1978. The physiological importance of AGXT2 was largely overlooked for three decades because AGXT2 is less active in glyoxylate metabolism than AGXT1, the enzyme that is deficient in primary hyperoxaluria type I.
Roman N, Rodionov   +3 more
openaire   +2 more sources

Evolutionary origin and functional diversification of aminotransferases [PDF]

open access: yes, 2022
Aminotransferases (ATs) are pyridoxal 5′-phosphate–dependent enzymes that catalyze the transamination reactions between amino acid donor and keto acid acceptor substrates.
Yoshikuni, Yasuo   +10 more
core   +1 more source

Biological activity of humic substances in the liver of Mongolian gerbils (Meriones unguiculatus)

open access: yesVìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ, 2016
One important reason for non-use of medicinal drugs is their hepatotoxicity. The search for new natural biologically active substances with hepatoprotective properties and which are cost-effective is an important task today.
D. Serova, O. Taran, O. Dyomshina
doaj   +1 more source

Aspartate aminotransferase/alanine aminotransferase ratio and subsequent cancer development [PDF]

open access: yesCancer Medicine, 2021
AbstractBackgroundWe aimed to evaluate the association between the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio and subsequent development of any type of cancer in an apparently healthy population.MethodsWe conducted a retrospective cohort study at St. Luke's International Hospital, Tokyo, Japan between 2005 and 2018.
Daiki Kobayashi   +3 more
openaire   +3 more sources

Acylation of aspartate aminotransferase [PDF]

open access: yesBiochemical Journal, 1967
1. Acetylation of aspartate aminotransferase from pig heart inhibits completely the enzymic activity when the coenzyme is in the amino form (pyridoxamine phosphate) or when the coenzyme has been removed, but not when the coenzyme is in the aldehyde form (pyridoxal phosphate). 2.
C, Turano   +3 more
openaire   +2 more sources

Molecular mechanisms of metabolic disorders in the organs of rats of different ages affected by sodium nitrite in the context of tobacco intoxication

open access: yesRegulatory Mechanisms in Biosystems, 2017
Among pollutants a significant threat is posed by heavy metals, nitrate fertilizers and industrial waste. However, people also contribute to this threat through bad habits such as smoking and alcohol.
P. H. Lyhatskyi   +3 more
doaj   +1 more source

Biochemical and histological studies on the possible protective impact of the herb basil (Ocimum basilicum) on adriamycin induced toxicity in rats. I. Influence on the liver. [PDF]

open access: yesJournal of Bioscience and Applied Research, 2016
The purpose of this work was to evaluate the effect of basil (Ocimum basilicum) against hepatotoxicity induced in albino rats by the anticancer drug adriamycin (ADR).
M.F.F Bayomy, S.A. Sakr, Gendia S.E. M
doaj   +1 more source

Effectiveness of enterosgel usage in the conditions of simultaneous destruction of rats by karbofos and carbon tetrachloride

open access: yesRegulatory Mechanisms in Biosystems, 2014
The aim of our study was to examine the effectiveness of the enterosgel sorbent in the terms of simultaneous destruction of rats by karbofos and carbon tetrachloride.
L. А. Boyko   +2 more
doaj   +1 more source

Association between Serum Liver Enzymes and Cardiovascular Diseases: A Case-control Study among Adults with Cardiovascular Disease [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2022
Introduction: Cardiovascular Diseases (CVDs) are the leading cause of global morbidity and mortality. However, their prevalence is disproportionately distributed, with the highest rate in low-income countries, moderate in middle-income countries, and the
Naval Kishor Yadav   +5 more
doaj   +1 more source

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