Results 11 to 20 of about 63,089 (245)
Frontiers in Cardiovascular Medicine, 2022 Objectives Amiodarone is widely used to treat arrhythmia. However, amiodarone is known for its severe toxicity to the liver, lungs, and thyroid. Amiodarone causes liver damage ranging from asymptomatic serum aminotransferase elevation to hepatic failure ...
H. You +7 more
semanticscholar +1 more source
A multicenter retrospective cohort study on predicting the risk for amiodarone pulmonary toxicity
BMC Pulmonary Medicine, 2022 Background Amiodarone is one of the most commonly used anti-arrhythmic agents. Amiodarone pulmonary toxicity is a potentially fatal adverse effect associated with amiodarone use.
Wang Chun Kwok +4 more
doaj +1 more source
Effect of Amiodarone and Hypothermia on Arrhythmia Substrates During Resuscitation
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Amiodarone is administered during resuscitation, but its antiarrhythmic effects during targeted temperature management are unknown. The purpose of this study was to determine the effect of both therapeutic hypothermia and amiodarone on ...
Joseph S. Piktel +6 more
doaj +1 more source
Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Amiodarone Toxicity
International Journal of Molecular Sciences, 2021 Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans. It has previously been demonstrated that amiodarone and its metabolite (desethylamiodarone, DEA) can inhibit mitochondrial function, particularly complexes I ...
Alina M Bețiu +9 more
semanticscholar +1 more source
Pharmaceutics, 2022 Background: Adjusting drug therapy under veno-venous extracorporeal membrane oxygenation (VV ECMO) is challenging. Although impaired pharmacokinetics (PK) under VV ECMO have been reported for sedative drugs and antibiotics, data about amiodarone are ...
Mickaël Lescroart +9 more
doaj +1 more source
European Journal of Inflammation, 2022 Objectives: Atrial fibrillation (AF) is a common arrhythmia in clinics with a high mortality rate. Recently, statins combined with amiodarone and amiodarone alone were used in the treatment of AF.
Yingbiao Wu, Xi Zhu, Zhongping Ning
doaj +1 more source
Time‐to‐onset analysis of amiodarone‐associated thyroid dysfunction
Journal of Clinical Pharmacy and Therapeutics, 2020 Amiodarone (AMD) treatment is associated with a number of significant adverse effects including thyroid dysfunction. However, the relationship between the development of thyroid dysfunction and the dosage and treatment duration of AMD remains unclear ...
Sayoko Kinoshita +3 more
semanticscholar +1 more source
Circulation, 2020 Supplemental Digital Content is available in the text. Background: Antiarrhythmic drugs have not proven to significantly improve overall survival after out-of-hospital cardiac arrest from shock-refractory ventricular fibrillation/pulseless ventricular ...
M. Daya +16 more
semanticscholar +1 more source
Risk factors for amiodarone-induced thyroid dysfunction in Japan
Journal of Arrhythmia, 2016 Background: Amiodarone is associated with a number of significant adverse effects, including elevated transaminase levels, pulmonary fibrosis, arrhythmia, and thyroid dysfunction.
Sayoko Kinoshita +8 more
doaj +1 more source
Evaluation and Treatment of Amiodarone-Induced Thyroid Disorders.
Journal of Clinical Endocrinology and Metabolism, 2020 Amiodarone is a class III antiarrhythmic drug containing 37% iodine by weight, with a structure similar to that of thyroid hormones. Deiodination of amiodarone releases large amounts of iodine that can impair thyroid function, causing either ...
D. Ylli, L. Wartofsky, K. Burman
semanticscholar +1 more source