Results 21 to 30 of about 26,582 (250)
Cardiotoxicity of amitriptyline and doxepin [PDF]
Clinical Pharmacology and Therapeutics, 1981 The cardiotoxicity of the tricyclic antidepressants amitriptyline and doxepin were compared in an animal with acute overdose. The mean repetitive extrasystole threshold (RET) decreased 71.5% with amitriptyline and 27.5% with doxepin (mean blood levels 933 ng/ml and 1889 ng/ml). Physostigmine reversed these effects.
Tobis, Jonathan M, Aronow, Wilbert S
openaire +5 more sources
Cytoprotective Effects of Melatonin Against Amitriptyline-Induced Toxicity in Isolated Rat Hepatocytes [PDF]
Advanced Pharmaceutical Bulletin, 2015 Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are
Shohreh Taziki +3 more
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Frontiers in Psychiatry, 2022 Auditory hallucination is usually associated with psychiatric diseases and organic brain illness. It was rarely found as adverse events of antidepressants.
Motoko Watanabe +8 more
doaj +1 more source
BMC Neurology, 2012 Background Amitriptyline, a tricyclic antidepressant and potent use-dependent blocker of sodium channels, has been shown to attenuate acute and chronic pain in several preclinical modes.
Cheng Kuang-I +7 more
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Evaluation the effect of amitriptyline and/or ashwagandha on body weight in male rats
Al-SalamJournal for Medical Science, 2023 study aims to examine and compare the effects of amitriptyline and ashwagandha on body weight in male rats by measurement weight for 4 weeks after their exposure to these two compound.
Ghada A. Taqa, Ismail R. Idrees
doaj +1 more source
Advances in Pharmacological Sciences, 2015 The present study was designed to evaluate the acute and chronic antidepressant effect of genistein in combination with amitriptyline in mice. Animals were divided into six groups (n=6) for treatment with water, genistein, or amitriptyline, either alone ...
Gaurav Gupta +5 more
doaj +1 more source
Mechanisms of the Cardiotoxic Action of Amitriptyline
Общая реаниматология, 2011 Objective: to study the mechanisms of toxic action of amitriptyline on the myocardium. Material and methods. Investigations were conducted using the hearts from 30 outbred albino rats, which had been isolated and perfused according to the procedure ...
G. V. Chekmarev, V. T. Dolgikh
doaj +1 more source
Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity. [PDF]
PLoS ONE, 2011 Approximately 35 million people worldwide suffer from Alzheimer's disease (AD). Existing therapeutics, while moderately effective, are currently unable to stem the widespread rise in AD prevalence.
Wayne Chadwick +11 more
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Calcium channel blocker-induced depression: a case report from South India
Open Journal of Psychiatry and Allied Sciences, 2019 Flunarizine is a cerebro-selective calcium channel blocker, commonly prescribed for migraine prophylaxis and is considered as non-inferior to propranolol to reduce the frequency of migraine attacks.
Sumana Gundam, Keya Das
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PLoS ONE, 2020 Chronic pain and sleep have a bidirectional relationship that promotes a vicious circle making chronic pain more difficult to treat. Therefore, pain and sleep should be treated simultaneously.
Hisakatsu Ito +5 more
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