Results 51 to 60 of about 56,967 (294)

Tricyclic antidepressant amitriptyline inhibits autophagic flux and prevents tube formation in vascular endothelial cells

Basic & Clinical Pharmacology & Toxicology, 2018
Amitriptyline is a tricyclic antidepressant and an inhibitor of lysosomal acid sphingomyelinase (ASM). Amitriptyline is well known for its cardiovascular side effects and toxicity in psychiatric patients.
Ying-Chao Guan, Xiang Li, M. Umetani, K. Boini, Pin-Lan Li, Yang Zhang   +5 more
semanticscholar   +1 more source

Saliva as a TDM matrix and its application in the model‐informed precision dosing

The Journal of Clinical Pharmacology, EarlyView.
Abstract This study reviews the main points of saliva as a therapeutic drug monitoring (TDM) matrix, its advantages and limitations, the methods of saliva sample collection and testing, the types of drugs in saliva TDM, and the methods of establishing saliva population pharmacokinetic (Pop PK) models, as well as summarizes the experiences and ...
Baohua Xu, Yujie Wen, Jinxia Lu, Maobai Liu, Xin Luo, Wei Huang, Helin Xie, Yu Cheng, Hongqiang Qiu, Xuemei Wu   +9 more
wiley   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Validation of an Endoscopic Landmark for Injection of Internal Branch of Superior Laryngeal Nerve

The Laryngoscope, EarlyView.
This study validates a transnasal endoscopic approach to target the internal branch of the superior laryngeal nerve (iSLN) via the piriform sinus. Cadaveric analysis showed this method enables precise localization with minimal variability, offering a promising technique for treating laryngeal sensory dysfunction.
Yuki Tanigami, David Hortobagyi, Andrew J. Bowen, Chelsea Kruse, Seth H. Dailey   +4 more
wiley   +1 more source

Electrokinetic Manipulations Combined With Direct and Ambient Ionization Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) is a powerful analytical technique that typically involves sample preparation and online analytical separation before MS detection. Traditional methods often face bottlenecks in sample preparation and analytical separation, despite the rapid detection capabilities of MS.
Nicholas E. Manicke, Lahiru Wedasingha, Magnus Rydberg   +2 more
wiley   +1 more source

Disclosure and adverse effects of complementary and alternative medicine used by hospitalized patients in the North East of England [PDF]

, 2012
Objectives: This study aimed to investigate the prevalence, disclosure and adverse effects of complementary and alternative medicine (CAM) use in hospitalised patients, and to explore the associations between patients’ perceived side-effects and relevant
Baqir, wasim, Bello, Nusirat, McGarry, Kenneth, Winit -Watjana, Win   +3 more
core   +2 more sources

NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials [PDF]

, 2013
BACKGROUND HIV-associated distal sensory polyneuropathy (HIV-DSP) is the most frequently reported neurologic complication associated with HIV infection.
Brew, Bruce J, Brown, Stephen, Fisher, Martin, Larbalestier, Nicholas, Moyle, Graeme, Orkin, Chloe, Schifitto, Giovanni, Simpson, David M, Tobias, Jeffrey K, Vanhove, Geertrui F   +9 more
core   +1 more source

Influence of mirtazapine on salivary cortisol in depressed patients [PDF]

, 2003
Unlike other antidepressants, mirtazapine does not inhibit the reuptake of norepinephrine or serotonin but acts as an antagonist at presynaptic alpha(2)-receptors, at postsynaptic 5-HT2 and 5-HT3 receptors, and at histaminergic H1 receptors. Furthermore,
Baghai, Thomas C., Hennig, J., Laakmann, G., Schule, C.   +3 more
core   +1 more source

A Study on CYP2C19 and CYP2D6 Polymorphic Effects on Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Koreans

Clinical and Translational Science, 2017
We performed a double‐blinded, genotype‐based stratification study to explore the pharmacokinetics and pharmacodynamics of amitriptyline according to CYP2C19 and CYP2D6 genotype in Korean subjects.
S. Ryu, S. Park, J. Lee, Y. Kim, HS Na, HS Lim, Hy Choi, IY Hwang, Jg Lee, ZW Park, WY Oh, Jm Kim, S. Choi   +12 more
semanticscholar   +1 more source

Interstitial Cystitis/Bladder Pain Syndrome Patient Phenotyping

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims In April of 2025, the Wake Forest Institute for Regenerative Medicine hosted a Global Consensus meeting on IC/BPS in Winston‐Salem, NC. The goal of this meeting was to establish global consensus regarding diagnostic criteria, phenotyping, treatment outcome assessment, and etiopathology in interstitial cystitis/bladder pain syndrome (IC ...
Dylan T. Wolff, Stephen Tranchina, Andrew Schrepf, R. Christopher Doiron, Toby C. Chai, Stephen J. Walker   +5 more
wiley   +1 more source