Results 51 to 60 of about 26,582 (250)
Rules of Thumb for Estimating Drug Levels in Breast Milk: How Well Do They Work?
Clinical Pharmacology &Therapeutics, EarlyView.The American Academy of Pediatrics and the World Health Organization recommend exclusive breastfeeding for the first 6 months of life due to extensive benefits for the maternal–infant dyad. While over 90% of mothers initiate breastfeeding, continuation drops to 35% by 6 months, often due to concerns about medication safety.
Juliya Gasparyan +3 more
wiley +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives The aim of the present study was to investigate the analgesic effects of repetitive transcranial magnetic stimulation over the primary motor cortex (M1‐rTMS) using different stimulation parameters to explore the optimal stimulus condition for treating neuropathic pain.
Nobuhiko Mori +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan +6 more
wiley +1 more source
Saliva as a TDM matrix and its application in the model‐informed precision dosing
The Journal of Clinical Pharmacology, EarlyView.Abstract This study reviews the main points of saliva as a therapeutic drug monitoring (TDM) matrix, its advantages and limitations, the methods of saliva sample collection and testing, the types of drugs in saliva TDM, and the methods of establishing saliva population pharmacokinetic (Pop PK) models, as well as summarizes the experiences and ...
Baohua Xu +9 more
wiley +1 more source
PLoS ONE, 2023 BackgroundHalf the US population uses drugs with anticholinergic properties. Their potential harms may outweigh their benefits. Amitriptyline is among the most frequently prescribed anticholinergic medicinal products, is used for multiple indications ...
Maria-Sophie Brueckle +9 more
doaj +1 more source
JEADV Clinical Practice, EarlyView.Punch grafting was retrospectively evaluated in patients with chronic lower leg ulcers treated at Erasmus MC between 2018 and 2023. Median pain scores significantly decreased after 6 weeks. Opioid use declined and 30% of patients no longer required analgesics. Complete wound closure was achieved in 7% of cases.
M. van Zanten +4 more
wiley +1 more source
European Pharmaceutical Journal, 2016 The aim of our work was to investigate the effect of amitriptyline, citalopram and venlafaxine on the heart during ischemic- reperfusion (l-R) injury.
Vicen M., Gulač P., Stankovičová T.
doaj +1 more source
JEADV Clinical Practice, EarlyView.ABSTRACT Skin changes such as xerosis and pruritus are common complications among diabetes patients and may lead to serious adverse events such as diabetic foot syndrome and amputations. Evidence suggests that daily application of optimal skincare, including gentle cleansers and moisturizers, may help improve skin barrier function, preventing ...
Robert S. Kirsner +5 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2013 Background/Aims: Several recent studies revealed an accumulation of ceramide in bronchial, tracheal and intestinal epithelial cells of mice and patients with cystic fibrosis (CF). Normalization of ceramide concentrations in lungs of CF mice employing the
Lutz Nährlich +16 more
doaj +1 more source
The Laryngoscope, EarlyView.Prospective study from April 2021 to August 2024 of adult patients with refractory chronic cough undergoing SLN block. This prospective assessment indicates that nearly 2 in 3 refractory chronic cough patients respond positively at 2 weeks post injection, with around 50% of these initial improvers endorsing ongoing cough symptom improvement at 6–9 ...
Andrew T. Peachman +5 more
wiley +1 more source