Results 71 to 80 of about 47,538 (286)

Evaluation of person-level heterogeneity of treatment effects in published multiperson N-of-1 studies: systematic review and reanalysis. [PDF]

, 2018
OBJECTIVE:Individual patients with the same condition may respond differently to similar treatments. Our aim is to summarise the reporting of person-level heterogeneity of treatment effects (HTE) in multiperson N-of-1 studies and to examine the evidence ...
Balk, Ethan M, Chan, Jeffrey, Dubois, Robert W, Kent, David M, Kravitz, Richard L, Lai, Lana, Lutz, Jennifer S, Raman, Gowri, Shi, Jennifer   +8 more
core   +1 more source

Rules of Thumb for Estimating Drug Levels in Breast Milk: How Well Do They Work?

Clinical Pharmacology &Therapeutics, EarlyView.
The American Academy of Pediatrics and the World Health Organization recommend exclusive breastfeeding for the first 6 months of life due to extensive benefits for the maternal–infant dyad. While over 90% of mothers initiate breastfeeding, continuation drops to 35% by 6 months, often due to concerns about medication safety.
Juliya Gasparyan, Philip O. Anderson, Tamorah Lewis, Cindy H. T. Yeung   +3 more
wiley   +1 more source

Examination and characterisation of the effect of amitriptyline therapy for chronic neuropathic pain on neuropeptide and proteomic constituents of human cerebrospinal fluid

Brain, Behavior, & Immunity - Health, 2021
Introduction: Amitriptyline is prescribed to reduce the intensity of chronic neuropathic pain. There is a paucity of validated in vivo evidence in humans regarding amitriptyline’s mechanism of action.
Jonathan Royds, Hilary Cassidy, Melissa J. Conroy, Margaret R. Dunne, Joanne Lysaght, Connail McCrory   +5 more
doaj   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Modulation of nociception by amitriptyline hydrochloride in the Speke’s hinge‐back tortoise (Kiniskys spekii)

Veterinary Medicine and Science, 2021
Background There are limited studies on the utilization of analgesics in testudines. Management of pain in reptiles is by use of analgesics generally used in other vertebrate species.
Christopher M. Makau, Philemon K. Towett, Klas S.P. Abelson, Titus I. Kanui   +3 more
doaj   +1 more source

Toward a More accurate, Evidence‐Based Classification of CYP Inhibitors: A Critical Appraisal of Current Systems

Clinical Pharmacology &Therapeutics, EarlyView.
In this issue of CPT, Malavé et al. deliver a comprehensive reassessment of CYP2C19 inhibitor classifications through a systematic review of clinical drug–drug interaction (DDI) studies. While their findings bring clarity to specific discrepancies, this commentary explores the origins of such inconsistencies, particularly focusing on methodological ...
Janne T. Backman
wiley   +1 more source

Influence of mirtazapine on salivary cortisol in depressed patients [PDF]

, 2003
Unlike other antidepressants, mirtazapine does not inhibit the reuptake of norepinephrine or serotonin but acts as an antagonist at presynaptic alpha(2)-receptors, at postsynaptic 5-HT2 and 5-HT3 receptors, and at histaminergic H1 receptors. Furthermore,
Baghai, Thomas C., Hennig, J., Laakmann, G., Schule, C.   +3 more
core   +1 more source

A Retrospective Analysis Into the Effect of Punch Grafts in Patients With Chronic Ulcers of the Lower Leg

JEADV Clinical Practice, EarlyView.
Punch grafting was retrospectively evaluated in patients with chronic lower leg ulcers treated at Erasmus MC between 2018 and 2023. Median pain scores significantly decreased after 6 weeks. Opioid use declined and 30% of patients no longer required analgesics. Complete wound closure was achieved in 7% of cases.
M. van Zanten, J. E. Geskes, M. M. E. Thung, P. Velthuis, C. van Montfrans   +4 more
wiley   +1 more source

Phenotypic and functional assessment of two novel KCNQ2 gain-of-function variants Y141N and G239S and effects of amitriptyline treatment [PDF]

, 2023
Allan Bayat, Stefano Iavarone, Francesco Miceli, Anne Vagner Jakobsen, Katrine M. Johannesen, Marina Nikanorova, Rafał Ploski, Krystyna Szymańska, Robert Flamini, Edward C. Cooper, Sarah Weckhuysen, Maurizio Taglialatela, Rikke S. Møller   +12 more
openalex   +1 more source

NGX-4010, a capsaicin 8% patch, for the treatment of painful HIV-associated distal sensory polyneuropathy: integrated analysis of two phase III, randomized, controlled trials [PDF]

, 2013
BACKGROUND HIV-associated distal sensory polyneuropathy (HIV-DSP) is the most frequently reported neurologic complication associated with HIV infection.
Brew, Bruce J, Brown, Stephen, Fisher, Martin, Larbalestier, Nicholas, Moyle, Graeme, Orkin, Chloe, Schifitto, Giovanni, Simpson, David M, Tobias, Jeffrey K, Vanhove, Geertrui F   +9 more
core   +1 more source