Results 41 to 50 of about 654,842 (253)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The effect of simulated nitrogen deposition on soil chemical properties in maple plantation stand [PDF]

علوم محیطی, 2017
Introduction: The amount of nitrogen compounds released into the atmosphere has increased, and is higher in industrial areas due to the increasing usage of fossil fuels and chemical fertilizers (Gruber and Galloway, 2008).
Mehrcedeh Tafazoli, Hamid Jalilvand, Seyyed Mohammad Hojjati, Norbert Lamersdorf   +3 more
doaj  

Synthesis and Properties of Acyclic Ammonium-based Ionic Liquids with Allyl Substituents as Electrolytes

Molecules, 2009
Several new acyclic ammonium-TFSI ionic liquids with an allyl substituent(s) were synthesized and their physicochemical and electrochemical properties were characterized. [AAMM]Am-TFSI (3) with two allyl groups showed the widest electrochemical stability
Young Gyu Kim, Seung M. Oh, Junyoung Mun, Chang Young Choi, Taeeun Yim   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Combining PDMS Composite and Plasmonic Solid Chemosensors: Dual Determination of Ammonium and Hydrogen Sulfide as Biomarkers in a Saliva Single Test

Chemosensors
In recent years, in the field of bioanalysis, the use of saliva as a biological fluid for the determination of biomarkers has been proposed. Saliva analysis stands out for its simplicity and non-invasive sampling.
Belen Monforte-Gómez, Sergio Mallorca-Cebriá, Carmen Molins-Legua, Pilar Campíns-Falcó   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Endophytic Expression of nif Genes of Azoarcus sp. Strain BH72 in Rice Roots

Molecular Plant-Microbe Interactions, 1999
Transcriptional fusions of gusA and gfp to the nifH gene as well as immunogold labeling with antibodies against the iron protein of nitrogenase revealed high nitrogenase gene expression levels of the endophyte Azoarcus sp.
Tanja Egener, Thomas Hurek, Barbara Reinhold-Hurek   +2 more
doaj   +1 more source

Removal of nitrogen and phosphorus from water by sludge-based biochar modified by montmorillonite coupled with nano zero-valent iron

Water Science and Technology, 2022
Biochar prepared by thermal decomposition of sewage sludge is a new adsorbent for sludge resource utilization and aquatic environmental treatment. In this study, sewage sludge was used as raw material for the preparation of pyrolysis sludge-based biochar.
Dezhi Xu, Xiulei Fan, Qing Chen, Shuyun Qiao, Jiankun Zhang, Yangyang Yang, Hong Wang, Linjun Zhang, Jun Hou   +8 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Synthesis of zeolites and their application as soil amendments to increase crop yield and potentially act as controlled release fertilizers. [PDF]

, 2005
A Thesis Submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of Philosophy.Zeolites have been used in agriculture since the 1960s, due to the effectiveness of these crystalline microporous ...
Jakkula, Vijay S.
core   +3 more sources