Results 51 to 60 of about 586,823 (315)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Nitrogen regulation of protein–protein interactions and transcript levels of GlnK PII regulator and AmtB ammonium transporter homologs in Archaea

, 2013
Gene homologs of GlnK PII regulators and AmtB-type ammonium transporters are often paired on prokaryotic genomes, suggesting these proteins share an ancient functional relationship.
Soppa, Jörg, Lange, Christian, Maupin-Furlow, Julie, Pedro-Roig, Laia, Pedro Roig, Laia, Bonete, María-José, Bonete, María José   +6 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Selective Recognition of Quaternary Ammonium Cations

, 2023
Selective recognition of ammonium cations fundamentally relies on their degree of substitution. In biological systems, proteins can preferentially bind more substituted ammonium cations over less substituted homologues.
Abby, Haworth, Emma, Winful, Dmitry, Yufit, Clare, Mahon, Matthew, Kitching, Emma, Wolpert, Emanuella, Fiandra, Callum , Begg, Karen, Johnston, Kim, Jelfs, Mark , Walsh, Joseph, Phelps   +11 more
core   +1 more source

Ammonium and methyl ammonium transport by RhAG

The FASEB Journal, 2012
The erythroid Rh protein (RhAG) is one component of the “Rh complex” that is known for its immunogenic characteristics. Recently, a role of RhAG in transport of ions has been proposed. In this study, we characterized NH 3 /NH 4 ...
Tolga Caner, Solange Abdulnour-Nakhoul, Karen Brown, L. Lee Hamm, Nazih Nakhoul   +4 more
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Ammonium Phenylphosphonamidodiselenoates and Phenylphosphonamidodi-selenoic Diamides from the Selenation of Primary and Secondary Amines

, 2014
The authors are thankful to the University of St Andrews and the Engineering and Physical Science Research Council (EPSRC, U.K.) for financial support.By reacting two equivalents of primary or secondary amines with 2,4-bis(phenyl)-1,3 ...
Woollins, J. Derek, Randall, Rebecca A. M., Hua, Guoxiong, Slawin, Alexandra M. Z.   +3 more
core   +1 more source

The effect of simulated nitrogen deposition on soil chemical properties in maple plantation stand [PDF]

علوم محیطی, 2017
Introduction: The amount of nitrogen compounds released into the atmosphere has increased, and is higher in industrial areas due to the increasing usage of fossil fuels and chemical fertilizers (Gruber and Galloway, 2008).
Mehrcedeh Tafazoli, Hamid Jalilvand, Seyyed Mohammad Hojjati, Norbert Lamersdorf   +3 more
doaj  

Synthesis and Properties of Acyclic Ammonium-based Ionic Liquids with Allyl Substituents as Electrolytes

Molecules, 2009
Several new acyclic ammonium-TFSI ionic liquids with an allyl substituent(s) were synthesized and their physicochemical and electrochemical properties were characterized. [AAMM]Am-TFSI (3) with two allyl groups showed the widest electrochemical stability
Young Gyu Kim, Seung M. Oh, Junyoung Mun, Chang Young Choi, Taeeun Yim   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source