Results 61 to 70 of about 190,766 (251)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Modeling the Ability of a Maize–Olive Agroforestry System in Nitrogen and Herbicide Pollution Reduction Using RZWQM2 and Comparison with Field Measurements

Agronomy, 2022
Agricultural pollution models are a valuable tool for researchers and managers to predict and assess the potential contamination from the use of fertilizers and pesticides in the field.
George Pavlidis, Vassilios A. Tsihrintzis   +1 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Influence of pre-crop and root architecture on the mobilization of non-exchangeable NH4+

Plant, Soil and Environment, 2014
It is well established that non-exchangeable NH4+ is an important N source for plants. However, release from clay minerals only occurs when the NH4+ concentration of the mineral environment declines below a certain level.
P. Beuters, T. Eichert, H.W. Scherer
doaj   +1 more source

Spatial Distribution and Mobility of Nutrients on Sand Mulching Soil for Fertigated Green Bean Crops under Greenhouse Conditions in Southern Spain: (I) Macronutrients

Agronomy, 2021
Information about the nutrients distribution in sand-mulched soils is rather scarce; therefore, the aim of this experiment was to determine the spatial distribution and mobility of macronutrients in the wet bulb zone in two sand-mulched soils (a ...
Alfonso Llanderal, Pedro Garcia-Caparros, Juana Isabel Contreras, María Teresa Lao, María Luz Segura   +4 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Application of Spruce Bark Biochar Minimizes Nitrogen and Carbon Leaching from an Eastern Newfoundland Podzolic Soil

Plants
Biochar has broad applications in agriculture, where its incorporation into soils is recognized as an effective strategy for improving soil quality, enhancing remediation, sequestering carbon, and mitigating climate change.
Riad O. Eissa, Lordwin Jeyakumar, David B. McKenzie, Jianghua Wu   +3 more
doaj   +1 more source

The impact of nitrogen fertilizer injection on kernel yield and yield formation of maize

Plant, Soil and Environment, 2014
In field experiments over three vegetation periods (2010-2012) we studied impact of the CULTAN (controlled uptake long term ammonium nutrition) method on yield and yield parameters of kernel maize. The field experiments were conducted at three sites with
K. Kubešová, J. Balík, O. Sedlář, L. Peklová   +3 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Impact of nitrogen fertilizer injection on grain yield and yield formation of spring barley (Hordeum vulgare L.)

Plant, Soil and Environment, 2011
The experiment was carried out to observe the influence of the CULTAN method (controlled uptake long term ammonium nutrition) on grain yield and yield formation of spring barley cultivar Jersey.
O. Sedlář, J. Balík, O. Kozlovský, L. Peklová, K. Kubešová   +4 more
doaj   +1 more source