Decreased Prevalence of Plasmodium Falciparum Resistance Markers to Amodiaquine Despite its wide Scale use as ACT Partner Drug in Zanzibar. [PDF]
, 2012 Zanzibar has recently undergone a rapid decline in Plasmodium falciparum transmission following combined malaria control interventions with artemisinin-based combination therapy (ACT) and integrated vector control.
Björkman, Anders +7 more
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British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 968-980, April 2025.Infants bear a significant malaria burden but are usually excluded from participating in early dose optimization studies that inform dosing regimens of antimalarial therapy. Unlike older children, infants' exclusion from early‐phase trials has resulted in limited evidence to guide accurate dosing of antimalarial treatment for uncomplicated malaria or ...
Clifford G. Banda +2 more
wiley +1 more source
Response to malaria epidemics in Africa. [PDF]
, 2007 Malaria epidemics affect nonimmune populations in many highland and semi-arid areas of Africa. Effective prevention of these epidemics is challenging, particularly in the highlands where predictive accuracy of indicators is not sufficiently high to allow
Abeku, Tarekegn A
core +3 more sources
High Efficacy of Two Artemisinin-Based Combinations (Artesunate + Amodiaquine and Artemether + Lumefantrine) in Caala, Central Angola. [PDF]
, 2006 In April 2004, 137 children 6-59 months of age with uncomplicated Plasmodium falciparum (Pf) malaria (Caala, Central Angola) were randomized to receive either artemether-lumefantrine (Coartem) or artesunate + amodiaquine (ASAQ).
Balkan, S +10 more
core +1 more source
Pharmacokinetics of Quinine, Chloroquine and Amodiaquine
Clinical Pharmacokinetics, 1996 Malaria is associated with a reduction in the systemic clearance and apparent volume of distribution of the cinchona alkaloids; this reduction is proportional to the disease severity. There is increased plasma protein binding, predominantly to alpha 1-acid glycoprotein, and elimination half-lives (in healthy adults quinine t1/2z = 11 hours, quinidine ...
Sanjeev Krishna +2 more
openaire +4 more sources
Temporal changes in haematocrit following artemisinin-based combination treatments of uncomplicated falciparum malaria in children [PDF]
, 2015 Semilog plots of deficit in haematocrit from 30Â % versus time in children with haematocrit
Adejumoke I. Ayede +6 more
core +4 more sources
Antimalarial Drugs-Induced Hepatic Injury in Rats and the Protective Role of Carnosine
Pharmaceutical Sciences, 2016 Background: Chloroquine and amodiaquine are used in the prophylaxis and treatment of malaria. However, hepatic injury is associated with malaria drug therapy. On the other hand, there is no promising hepatoprotective agent for prophylaxis or treatment of
Akram Jamshidzadeh, Reza Heidari, Farzaneh Abazari, Maral Ramezani, Forouzan Khodaei, Mohammad Mehdi Ommati, Maryam Ayarzadeh, Roya Firuzi, Arastoo Saeedi, Negar Azarpira, Asma Najibi
doaj +1 more source
Early Changes in Plasmodium falciparum Asexual and Sexual Populations in Children with Acute Infections Following Treatment with Artemisinin-Based Combination Drugs [PDF]
, 2012 Artemisinin-based combination therapies (ACTs) may influence malaria transmission but the early changes in parasite populations have not been frequently evaluated.
Gbotosho, Grace O. +3 more
core +1 more source
Drugs in R&D, 2020 Background In 2006, the National Malaria Control Program in Mali recommended artemisinin-based combination therapy as the first-line treatment for uncomplicated malaria.
Karim Traoré +12 more
doaj +1 more source
The Pharmacogenetics of the Antimalarial Amodiaquine
, 2012 Jose Pedro Gil1,2,3 1Department of Physiology and Pharmacology, Drug Resistance Unit, Division of Pharmacogenetics, Karolinska Institutet, Stockholm, 2Department of Biomedical Sciences, University of Algarve IBB-Institute for Biotechnology and Bioengineering, The Centre for Molecular and Structural Biomedicine, Gambelas, 3Department of Biological ...
openaire +4 more sources