Results 101 to 110 of about 15,149 (207)

Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso

Malaria Journal, 2008
Background Combination therapy has become a new paradigm in malaria treatment. Amodiaquine is a common partner drug in different malaria combination therapies used or investigated in sub-Saharan Africa, but data on its efficacy as a single drug are ...
Meissner Peter, Coulibaly Boubacar, Mockenhaupt Frank P, Mandi Germain, Müller Olaf   +4 more
doaj   +1 more source

Risk associated with asymptomatic parasitaemia occurring post-antimalarial treatment [PDF]

, 2008
OBJECTIVE: Parasites may recur asymptomatically after initial clearance by antimalarial treatment. Current guidelines recommend treatment only when patients develop symptoms or at the end of follow-up. We wanted to assess prospectively the probability of
Guthmann, Missinou, Mutabingwa, Njama-Meya, White, WHO, WHO, WHO, WHO   +8 more
core   +2 more sources

Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine [PDF]

, 2018
Stephen Walimbwa, Mohammed Lamorde, Catriona Waitt, Julian Kaboggoza, Laura Else, Pauline Byakika‐Kibwika, Alieu Amara, Joshua Gini, Markus Winterberg, Justin Chiong, Joel Tärning, Saye Khoo   +11 more
openalex   +1 more source

Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo

Memorias do Instituto Oswaldo Cruz, 2007
Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear.
Akintunde Sowunmi, Grace O Gbotosho, Christian T Happi, Ahmed A Adedeji, Olayinka M Bolaji, Fatai A Fehintola, Babasola A Fateye, Ayoade MJ Oduola   +7 more
doaj  

Distribution of the cytochrome P450 CYP2C8*2 allele in Brazzaville, Republic of Congo

International Journal of Infectious Diseases, 2019
Background: Cytochrome P450 (CYP) enzymes are essential in the metabolism of most drugs used today. Single nucleotide polymorphism(s) occurring in CYP genes can adversely affect drug pharmacokinetics, efficacy, and safety. Individuals carrying the CYP2C8*
Simon Marie Peko, Francine Ntoumi, Christevy Vouvoungui, David Nderu, Simon Charles Kobawila, Thirumalaisamy P. Velavan, Félix Koukouikila-Koussounda   +6 more
doaj   +1 more source

Amodiaquine as COVID-19 Mpro Inhibitor: A Theoretical Study [PDF]

, 2020
bnacharya Acharya
openalex   +1 more source

Prevalence of CYP2C8*2 and *3 among Eritreans and its Potential Impact on Artesunate/Amodiaquine Treatment

Pharmacogenomics and Personalized Medicine, 2020
Lidia Habtemikael,1 Mulugeta Russom,2 Iyassu Bahta,2 Selam Mihreteab,3 Araia Berhane,4 Andreas Mårtensson,1 Jose Pedro Gil1,5,6 1Department of Women’s and Children’s Health, International Maternal and Child Health (IMCH), Uppsala ...
Habtemikael L, Russom M, Bahta I, Mihreteab S, Berhane A, Mårtensson A, Gil JP   +6 more
doaj  

In silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates.

, 2014
A sequence of computational methods was used for predicting novel drug targets against drug resistant malaria parasite Plasmodium falciparum. Comparative genomics, orthologous protein analysis among same and other malaria parasites and protein-protein ...
Altschul, Andrews, Anishetty, Arama, Berman, Bernstein, Bhasin, Boeckmann, Chang, Chawley, Chen, Colovos, Corpet, David Charles Warhurst, Eisenberg, Finn, Franceschini, Ghosh, Irwin, Irwin, Kanehisa, Konc, Krogh, Kushwaha, Larsen, Laskowski, Ludin, Miller, Morris, Mrutyunjay Suar, Mulder, Pieper, Pierleoni, Pontius, Rajani Kanta Mahapatra, Sali, Subhashree Rout, Sun, Tam, von Mering, Wallner, Wiederstein, World Health Organization, Yang, Yeh, Zhexin   +45 more
core   +1 more source

Amodiaquine ameliorates stress-induced premature cellular senescence via promoting SIRT1-mediated HR repair

Cell Death Discovery
DNA damage is considered to be a potentially unifying driver of ageing, and the stalling of DNA damage repair accelerates the cellular senescence. However, augmenting DNA repair has remained a great challenge due to the intricate repair mechanisms ...
Jie Du, Fuqiang Chen, Chenghong Du, Wenna Zhao, Zihan Chen, Zhenhua Ding, Meijuan Zhou   +6 more
doaj   +1 more source

Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria

Bulletin of the World Health Organization
OBJECTIVE: To test a novel methodology to define age-based dosing regimens for the treatment of malaria with a new, user-friendly, blister-packaged fixed-dose combination of artesunate and amodiaquine.
Walter RJ Taylor, Dianne J Terlouw, Piero L Olliaro, Nicholas J White, Philippe Brasseur, Feiko O ter Kuile   +5 more
doaj   +1 more source