Results 101 to 110 of about 13,912 (195)

Prevalence of CYP2C8*2 and *3 among Eritreans and its Potential Impact on Artesunate/Amodiaquine Treatment

Pharmacogenomics and Personalized Medicine, 2020
Lidia Habtemikael,1 Mulugeta Russom,2 Iyassu Bahta,2 Selam Mihreteab,3 Araia Berhane,4 Andreas Mårtensson,1 Jose Pedro Gil1,5,6 1Department of Women’s and Children’s Health, International Maternal and Child Health (IMCH), Uppsala ...
Habtemikael L, Russom M, Bahta I, Mihreteab S, Berhane A, Mårtensson A, Gil JP   +6 more
doaj  

Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo

Memorias do Instituto Oswaldo Cruz, 2007
Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear.
Akintunde Sowunmi, Grace O Gbotosho, Christian T Happi, Ahmed A Adedeji, Olayinka M Bolaji, Fatai A Fehintola, Babasola A Fateye, Ayoade MJ Oduola   +7 more
doaj  

Amodiaquine ameliorates stress-induced premature cellular senescence via promoting SIRT1-mediated HR repair

Cell Death Discovery
DNA damage is considered to be a potentially unifying driver of ageing, and the stalling of DNA damage repair accelerates the cellular senescence. However, augmenting DNA repair has remained a great challenge due to the intricate repair mechanisms ...
Jie Du, Fuqiang Chen, Chenghong Du, Wenna Zhao, Zihan Chen, Zhenhua Ding, Meijuan Zhou   +6 more
doaj   +1 more source

Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria

Bulletin of the World Health Organization
OBJECTIVE: To test a novel methodology to define age-based dosing regimens for the treatment of malaria with a new, user-friendly, blister-packaged fixed-dose combination of artesunate and amodiaquine.
Walter RJ Taylor, Dianne J Terlouw, Piero L Olliaro, Nicholas J White, Philippe Brasseur, Feiko O ter Kuile   +5 more
doaj   +1 more source

Examination of effectiveness of chemical scavengers as therapeutics in organophosphate poisoning [PDF]

, 2017
Cholinergic crisis triggered by inhibition of cholinesterases via organophosphorus nerve agents (OP) and pesticides is treated with atropine and a reactivator of inhibited cholinesterase, called oxime.
Bierwisch, Anne
core  

Voacanga africana-artesunate and Voacanga africana-amodiaquine combinations as effective anti-plasmodial agents in mice

Scientific African
Background: Malaria is a global health problem due to its high incidence of morbidity and mortality, especially in children and pregnant women. However, the Plasmodium parasite frequently develops resistance to chemotherapy, triggering continuous ...
Daniel Ampomah Frimpong, Aliu Moomin, Samuel Asare Nkansah, Aaron Opoku Antwi, Abubakar Ibn Sidik, Paa Kofi Tawiah Adu-Gyamfi, Kwesi Boadu Mensah   +6 more
doaj   +1 more source

NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination.

, 2010
We characterized vaccine-induced cellular responses to rabies virus in naive adult volunteers. Contrary to current paradigms, we observed potent and prolonged in vitro NK cell cytokine production and degranulation responses after restimulation of PBMCs ...
Behrens, Ron H, Fooks, Anthony R, Horowitz, Amir, Okell, Lucy, Riley, Eleanor M   +4 more
core   +1 more source

Population pharmacokinetics of amodiaquine and piperaquine in African pregnant women with uncomplicated Plasmodium falciparum infections

CPT: Pharmacometrics & Systems Pharmacology
Artemisinin‐based combination therapy (ACT) is the first‐line recommended treatment for uncomplicated malaria. Pharmacokinetic (PK) properties in pregnant women are often based on small studies and need to be confirmed and validated in larger pregnant ...
Junjie Ding, Richard M. Hoglund, Harry Tagbor, Halidou Tinto, Innocent Valéa, Victor Mwapasa, Linda Kalilani‐Phiri, Jean‐Pierre Van Geertruyden, Michael Nambozi, Modest Mulenga, Sebastian Hachizovu, Raffaella Ravinetto, Umberto D'Alessandro, Joel Tarning   +13 more
doaj   +1 more source

PBPK‐led assessment of antimalarial drugs as candidates for Covid‐19: Simulating concentrations at the site of action to inform repurposing strategies

Clinical and Translational Science
The urgent need for safe, efficacious, and accessible drug treatments to treat coronavirus disease 2019 (COVID‐19) prompted a global effort to evaluate drug repurposing opportunities.
Nada Abla, Lisa M. Almond, Jennifer J. Bonner, Naomi Richardson, Timothy N. C. Wells, Jörg J. Möhrle   +5 more
doaj   +1 more source

Amodiaquine [PDF]

, 2020
openaire   +1 more source