Results 101 to 110 of about 17,783 (291)

Involvement of CCL2/CCR2 macrophage recruitment in amodiaquine-induced liver injury

Journal of Immunotoxicology, 2019
Evidence suggests that macrophages may play a role in the development of idiosyncratic drug-induced liver injury (IDILI). However, there has yet to be a clear link between macrophage activation and the inflammatory infiltrate that is characteristic of ...
A. Mak, J. Uetrecht
semanticscholar   +1 more source

Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial. [PDF]

, 2018
BACKGROUND: Primaquine and methylene blue are gametocytocidal compounds that could prevent Plasmodium falciparum transmission to mosquitoes. We aimed to assess the efficacy and safety of primaquine and methylene blue in preventing human to mosquito ...
Bousema, Teun, Bradley, John, Brown, Joelle M, Chen, Ingrid, Diarra, Kalifa, Diawara, Halimatou, Dicko, Alassane, Drakeley, Chris, Gosling, Roly, Hwang, Jimee, Issiaka, Djibrilla, Keita, Sekouba, Kone, Daouda T, Lanke, Kjerstin, Mahamar, Almahamoudou, McCulloch, Charles, Müller, Olaf, Roh, Michelle E, Sanogo, Koualy, Soumare, Harouna M, Srinivasan, Vinay, Stone, Will JR, Traore, Sekou F   +22 more
core   +2 more sources

Plasmodium falciparum genetic factors rather than host factors are likely to drive resistance to ACT in Ghana

Malaria Journal, 2020
Background Artemisinin-based combination therapy (ACT) partner drugs, currently used in Ghana are lumefantrine, amodiaquine and piperaquine. Plasmodium falciparum isolates with reduced susceptibility to these partner drugs may affect treatment outcome ...
Peter Hodoameda, Nancy Odurowah Duah-Quashie, Charles Oheneba Hagan, Sena Matrevi, Benjamin Abuaku, Kwadwo Koram, Neils Ben Quashie   +6 more
doaj   +1 more source

In Vitro Evaluation of CYP‐Mediated Metabolism of Fezolinetant and Pharmacokinetic Interaction Between Fezolinetant and Fluvoxamine in Healthy Postmenopausal Smokers and Nonsmokers

The Journal of Clinical Pharmacology, Volume 65, Issue 4, Page 508-519, April 2025.
Abstract Fezolinetant is an oral, nonhormonal, neurokinin 3 receptor antagonist treatment option for moderate to severe vasomotor symptoms associated with menopause. An in vitro study using human recombinant cytochrome P450 (CYP) enzymes and human liver microsomes showed that fezolinetant is metabolized to its major but inactive metabolite, ES259564 ...
Megumi Iwai, Jace Nielsen, Mayuko Miyagawa, Melanie Patton, Peter L. Bonate, Xuegong Wang, Tomasz Wojtkowski, Angela Sinn, Jiayin Huang   +8 more
wiley   +1 more source

Response to Buffet et al: Intermittent preventive anti-malarial treatment to children (IPTc): firebreak or fire trap?

, 2008
Buffet and colleagues have reviewed some of the potential benefits and drawbacks of intermittent preventive antimalarial treatment in children (IPTc).
Bojang, Kalifa, Chandramohan, Daniel, Cisse, Badara, Greenwood, Brian, Kweku, Margaret, Milligan, Paul   +5 more
core   +1 more source

Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children

Memorias do Instituto Oswaldo Cruz, 2008
Characteristics of primary and recrudescent Plasmodium falciparum infections were evaluated in 25 children who did not recover after amodiaquine (AQ) treatment. Recrudescence was detected by a thick blood smear and confirmed by polymerase chain reaction.
Akintunde Sowunmi, Sulayman T Balogun, Grace O Gbotosho, Christian T Happi   +3 more
doaj   +1 more source

Use of population pharmacokinetic‐pharmacodynamic modelling to inform antimalarial dose optimization in infants

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 968-980, April 2025.
Infants bear a significant malaria burden but are usually excluded from participating in early dose optimization studies that inform dosing regimens of antimalarial therapy. Unlike older children, infants' exclusion from early‐phase trials has resulted in limited evidence to guide accurate dosing of antimalarial treatment for uncomplicated malaria or ...
Clifford G. Banda, Joel Tarning, Karen I. Barnes   +2 more
wiley   +1 more source

Molecular markers of resistance to amodiaquine plus sulfadoxine–pyrimethamine in an area with seasonal malaria chemoprevention in south central Niger

Malaria Journal, 2018
In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine–pyrimethamine (AQ + SP) is recommended in the ...
R. Grais, I. Laminou, Lynda Woi-Messe, Rockyath Makarimi, Seidou H. Bouriema, C. Langendorf, A. Amambua-Ngwa, U. d’Alessandro, P. Guérin, T. Fandeur, C. Sibley   +10 more
semanticscholar   +1 more source

Fixed dose artesunate amodiaquine – a phase IIb, randomized comparative trial with non-fixed artesunate amodiaquine [PDF]

Malaria Journal, 2014
Pharmacokinetic (PK) and pharmacodynamic (PD) data are limited for artesunate (AS) and amodiaquine (AQ) in uncomplicated Plasmodium falciparum.From 2007-8, 54 P. falciparum-infected, Kenyan adults were assigned randomly fixed dose (FD) ASAQ (n = 26) or non-fixed (NF) ASAQ (n = 28).
Ogutu, Bernhards, Juma, Elizabeth, Obonyo, Charles, Jullien, Vincent, Carn, Gwenaelle, Vaillant, Michel, Taylor, Walter Robert John, Kiechel, Jean-René   +7 more
openaire   +4 more sources

Phytochemical Screening and in vivo antioxidant activity of Ethanolic extract of caesalpinia bondus (L.) Roxb [PDF]

, 2012
Phytochemical screening, antioxidant activity in vivo and lipid peroxidation of 75 % ethanolic extract of young twigs and leaves of Caesalpinia bonduc were carried out by chemical test, and assessment of catalase and peroxidase activities and lipid ...
Akindahunsi , A. A, Ntube , C. A, Ogunlana , O. E, Ogunlana , O. O, Olagunju , J. A   +4 more
core   +1 more source