Results 11 to 20 of about 15,045 (253)

Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy [PDF]

Journal of Tropical Medicine, 2015
Objective. The study was designed to determine the efficacy of combined Amodiaquine and Ciprofloxacin in plasmodiasis therapy. Method. The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations ...
Peace Mayen Edwin Ubulom, Chinweizu Ejikeme Udobi, Mark Iheukwumere Madu   +2 more
doaj   +3 more sources

Amodiaquine for treating malaria

Cochrane Database of Systematic Reviews, 2003
Amodiaquine has been widely used to treat malaria. Fatal adverse reactions have been reported in adults taking it for prophylaxis. This has led some authorities to suggest it is withdrawn as a first line treatment for malaria.To compare amodiaquine with chloroquine or sulfadoxine-pyrimethamine for treating uncomplicated Plasmodium falciparum malaria.We
Piero Olliaro, Paola Mussano
openalex   +6 more sources

Questions about the antimalarial amodiaquine [PDF]

The Lancet, 2003
Sarah G. Staedke, Grant Dorsey, Philip J. Rosenthal   +2 more
  +6 more sources

AMODIAQUINE AND COMBINATION CHEMOTHERAPY FOR MALARIA [PDF]

The American Journal of Tropical Medicine and Hygiene, 2005
Steven R. Meshnick, Alisa P. Alker
openalex   +3 more sources

Dose-Optimization of a Novel Co-Formulated Triple Combination Antimalarial Therapy: Artemether-Lumefantrine-Amodiaquine. [PDF]

Clin Pharmacol Ther
Artemisinin‐based combination therapy (ACT) is the first‐line therapy for uncomplicated falciparum malaria, but artemisinin resistance in Asia and now sub‐Saharan Africa is threatening our ability to control and eliminate malaria. Triple‐ACTs have emerged as a viable alternative treatment to combat declining ACT efficacy due to drug‐resistant malaria ...
Tarning J, White NJ, Dondorp AM.
europepmc   +2 more sources

Pharmacokinetics of intravenous amodiaquine. [PDF]

British Journal of Clinical Pharmacology, 1987
Amodiaquine hydrochloride (3 mg base kg‐1) was given by constant rate intravenous injection over 10 min to seven healthy adult male volunteers, and by constant rate infusion (10 mg base kg‐1) over 4 h to 10 adult patients admitted to hospital with falciparum malaria.
White, N, Looareesuwan, S, Edwards, G, Phillips, R, Karbwang, J, Nicholl, D, Bunch, C, Warrell, D   +7 more
openaire   +4 more sources

Amodiaquine promotes testosterone production and de novo synthesis of cholesterol and triglycerides in Leydig cells

Journal of Lipid Research, 2021
Testosterone is a hormone essential for male reproductive function. It is produced primarily by Leydig cells in the testicle through activation of steroidogenic acute regulatory protein and a series of steroidogenic enzymes, including a cytochrome P450 ...
Yujeong Choi, Eun Goo Lee, Gibbeum Lee, Mi Gyeong Jeong, Hyo Kyeong Kim, Ji-Hyun Oh, Sung Won Kwon, Eun Sook Hwang   +7 more
doaj   +1 more source

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Adam, Ishag, Ademowo, George, Arze, Cesar, Asaq Molecular Marker Study Group, Baliraine, Frederick N, Berens-Riha, Nicole, Björkman, Anders, Borrmann, Steffen, Checchi, Francesco, Dahal, Prabin, Davis, Timothy ME, Desai, Meghna, Dhorda, Mehul, Djimdé, Abdoulaye A, Dorsey, Grant, El-Sayed, Badria B, Eshetu, Teferi, Eyase, Frederick, Falade, Catherine, Faucher, Jean-François, Fröberg, Gabrielle, Gadalla, Nahla B, Grivoyannis, Anastasia, Guérin, Philippe, Hamour, Sally, Houzé, Sandrine, Johnson, Jacob, Kamugisha, Erasmus, Kariuki, Simon, Kiechel, Jean-René, Kironde, Fred, Kofoed, Poul-Erik, LeBras, Jacques, Malmberg, Maja, Moriera, Clarissa, Mwai, Leah, Mårtensson, Andreas, Ménard, Didier, Ngasala, Billy, Nosten, Francois, Nsanzabana, Christian, Nsobya, Samuel L, Nzila, Alexis, Oguike, Mary, Ogutu, Bernhards, Otienoburu, Sabina Dahlström, Ouédraogo, Jean-Bosco, Piola, Patrice, Plowe, Christopher V, Price, Ric N, Rombo, Lars, Rosenthal, Philip J, Schramm, Birgit, Sibley, Carol Hopkins, Somé, A Fabrice, Stepniewska, Kasia, Sutherland, Colin J, Thwing, Julie, Ursing, Johan, Venkatesan, Meera, Wong, Rina PM, Zeynudin, Ahmed, Zongo, Issaka   +62 more
core   +3 more sources

Susceptibility of Colombian Plasmodium falciparum isolates to 4-aminoquinolines and the definition of amodiaquine resistance in vitro

Memorias do Instituto Oswaldo Cruz, 2006
There are wide variations in the threshold used to define in vitro resistance of Plasmodium falciparum to amodiaquine (AQ), probably due to differences in methodology and interpretation. In vitro susceptibility data of Colombian P.
Diego F Echeverry, Claribel Murillo, Restrepo P Piedad, Lyda Osorio   +3 more
doaj   +1 more source

Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria

Malaria Journal, 2021
Background Accurate measurement of anti-malarial drug concentrations in therapeutic efficacy studies is essential to distinguish between inadequate drug exposure and anti-malarial drug resistance, and to inform optimal anti-malarial dosing in key target ...
Thomas A. Anyorigiya, Sandra Castel, Katya Mauff, Frank Atuguba, Bernhards Ogutu, Abraham Oduro, David Dosoo, Kwaku-Poku Asante, Seth Owusu-Agyei, Alexander Dodoo, Abraham Hodgson, Fred Binka, Lesley J. Workman, Elizabeth N. Allen, Paolo Denti, Lubbe Wiesner, Karen I. Barnes   +16 more
doaj   +1 more source