Results 11 to 20 of about 17,708 (290)
Malaria Journal, 2021 Background Accurate measurement of anti-malarial drug concentrations in therapeutic efficacy studies is essential to distinguish between inadequate drug exposure and anti-malarial drug resistance, and to inform optimal anti-malarial dosing in key target ...
Thomas A. Anyorigiya +16 more
doaj +2 more sources
Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy [PDF]
Journal of Tropical Medicine, 2015 Objective. The study was designed to determine the efficacy of combined Amodiaquine and Ciprofloxacin in plasmodiasis therapy. Method. The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations ...
Peace Mayen Edwin Ubulom +2 more
doaj +3 more sources
Malaria Journal, 2021 Background The anti-malarial drug, amodiaquine, a commonly used, long-acting partner drug in artemisinin-based combination therapy, is metabolized to active desethyl-amodiaquine (DEAQ) by cytochrome P450 2C8 (CYP2C8).
Leyre Pernaute-Lau +5 more
doaj +2 more sources
The Pan African Medical Journal, 2020 INTRODUCTION: Artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) are the first line therapy of uncomplicated malaria in Burkina Faso. We assessed the treatment efficacy, tolerability of these drugs 11 years following its adoption as first ...
Issaka Zongo +7 more
doaj +2 more sources
Amodiaquine for treating malaria
Cochrane Database of Systematic Reviews, 2003 Amodiaquine has been widely used to treat malaria. Fatal adverse reactions have been reported in adults taking it for prophylaxis. This has led some authorities to suggest it is withdrawn as a first line treatment for malaria.To compare amodiaquine with chloroquine or sulfadoxine-pyrimethamine for treating uncomplicated Plasmodium falciparum malaria.We
Piero Olliaro, Paola Mussano
openalex +6 more sources
Questions about the antimalarial amodiaquine [PDF]
The Lancet, 2003 Sarah G. Staedke +2 more
+6 more sources
Dose-Optimization of a Novel Co-Formulated Triple Combination Antimalarial Therapy: Artemether-Lumefantrine-Amodiaquine. [PDF]
Clin Pharmacol TherArtemisinin‐based combination therapy (ACT) is the first‐line therapy for uncomplicated falciparum malaria, but artemisinin resistance in Asia and now sub‐Saharan Africa is threatening our ability to control and eliminate malaria. Triple‐ACTs have emerged as a viable alternative treatment to combat declining ACT efficacy due to drug‐resistant malaria ...
Tarning J, White NJ, Dondorp AM.
europepmc +2 more sources
A LC-MS/MS Assay for Quantification of Amodiaquine and Desethylamodiaquine in Dried Blood Spots on Filter Paper. [PDF]
Int J Anal ChemArtesunate–amodiaquine (ARS–AQ) is a first‐line antimalarial treatment recommended by the World Health Organization. AQ is the long acting partner drug in this combination, and therapeutic success is correlated with the terminal exposure to AQ. Dried blood spot (DBS) sampling for AQ is a convenient and minimally invasive technique, especially suitable ...
Kaewkhao N, Tarning J, Blessborn D.
europepmc +2 more sources
AMODIAQUINE AND COMBINATION CHEMOTHERAPY FOR MALARIA [PDF]
The American Journal of Tropical Medicine and Hygiene, 2005 Steven R. Meshnick, Alisa P. Alker
openalex +3 more sources
PLoS ONE, 2022 Background Sub-Saharan Africa has the highest burden of malaria in the world. Artemisinin-based combination therapies (ACTs) have been the cornerstone in the efforts to reduce the global burden of malaria.
K. Marwa +7 more
semanticscholar +1 more source