Results 31 to 40 of about 10,947 (204)

Clinical and In Vitro Resistance of Plasmodium falciparum to Artesunate-Amodiaquine in Cambodia

Clinical Infectious Diseases, 2020
Background Artesunate-amodiaquine is a potential therapy for uncomplicated malaria in Cambodia. Methods Between September 2016 and January 2017, artesunate-amodiaquine efficacy and safety were evaluated in a prospective, open-label, single-arm ...
Mélissa Mairet-Khedim, R. Leang, Camille Marmai, N. Khim, Saorin Kim, Sopheakvatey Ke, Chhayleang Kauy, Nimol Kloeung, Rotha Eam, Sophy Chy, B. Izac, Denis Mey Bouth, Maria Dorina Bustos, P. Ringwald, F. Ariey, B. Witkowski   +15 more
semanticscholar   +1 more source

The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data

BMC Medicine, 2020
The majority of Plasmodium falciparum malaria cases in Africa are treated with the artemisinin combination therapies artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ), with amodiaquine being also widely used as part of seasonal malaria ...
M. Bretscher, P. Dahal, J. Griffin, K. Stepniewska, Q. Bassat, E. Baudin, U. d’Alessandro, A. Djimde, G. Dorsey, E. Espié, Bakary Fofana, R. González, E. Juma, C. Karema, E. Lasry, B. Lell, N. Lima, C. Menéndez, G. Mombo-Ngoma, C. Moreira, Frederic Nikiema, J. Ouédraogo, S. Staedke, H. Tinto, I. Valéa, Adoke Yeka, A. Ghani, P. Guérin, L. Okell   +28 more
semanticscholar   +1 more source

Amodiaquine promotes testosterone production and de novo synthesis of cholesterol and triglycerides in Leydig cells

Journal of Lipid Research, 2021
Testosterone is a hormone essential for male reproductive function. It is produced primarily by Leydig cells in the testicle through activation of steroidogenic acute regulatory protein and a series of steroidogenic enzymes, including a cytochrome P450 ...
Yujeong Choi, Eun Goo Lee, Gibbeum Lee, Mi Gyeong Jeong, Hyo Kyeong Kim, Ji-Hyun Oh, Sung Won Kwon, Eun Sook Hwang   +7 more
doaj   +1 more source

Dolutegravir pharmacokinetics during co-administration with either artemether/lumefantrine or artesunate/amodiaquine.

Journal of Antimicrobial Chemotherapy, 2021
BACKGROUND In sub-Saharan Africa, artemisinin-containing therapies for malaria treatment are regularly co-administered with ART. Currently, dolutegravir-based regimens are recommended as first-line therapy for HIV across most of Africa.
A. Kawuma, S. Walimbwa, G. Pillai, S. Khoo, M. Lamorde, R. Wasmann, P. Denti   +6 more
semanticscholar   +1 more source

Susceptibility of Colombian Plasmodium falciparum isolates to 4-aminoquinolines and the definition of amodiaquine resistance in vitro

Memorias do Instituto Oswaldo Cruz, 2006
There are wide variations in the threshold used to define in vitro resistance of Plasmodium falciparum to amodiaquine (AQ), probably due to differences in methodology and interpretation. In vitro susceptibility data of Colombian P.
Diego F Echeverry, Claribel Murillo, Restrepo P Piedad, Lyda Osorio   +3 more
doaj   +1 more source

In vivo/ex vivo efficacy of artemether–lumefantrine and artesunate–amodiaquine as first-line treatment for uncomplicated falciparum malaria in children: an open label randomized controlled trial in Burkina Faso

Malaria Journal, 2020
Artemisinin-based combination therapy (ACT) is recommended to improve malaria treatment efficacy and limit drug-resistant parasites selection in malaria endemic areas.
Moussa Lingani, L. N. Bonkian, Isidore W. Yerbanga, Adama Kazienga, I. Valéa, H. Sorgho, J. Ouédraogo, P. Mens, H. Schallig, R. Ravinetto, U. d’Alessandro, H. Tinto   +11 more
semanticscholar   +1 more source

Effects of pyrimethamine-sulphadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulphadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children

Memorias do Instituto Oswaldo Cruz, 2006
The effects of pyrimethamine-sulphadoxine (PS), chloroquine plus chlorpheniramine, a H1 receptor antagonist that reverses chloroquine resistance in Plasmodium falciparum in vitro and in vivo (CQCP), and amodiaquine plus pyrimethamine-sulphadoxine (AQPS ...
A Sowunmi, AA Adedeji, GO Gbotosho, BA Fateye, TC Happi   +4 more
doaj   +1 more source

Cross-resistance of the chloroquine-derivative AQ-13 with amodiaquine in Cambodian Plasmodium falciparum isolates

Journal of Antimicrobial Chemotherapy, 2021
Background Expanding resistance to multiple antimalarials, including chloroquine, in South-East Asia (SEA) urges the development of new therapies.
F. Nardella, Mélissa Mairet-Khedim, C. Roesch, S. Maher, Sopheakvatey Ke, R. Leang, D. Leroy, B. Witkowski   +7 more
semanticscholar   +1 more source

Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, Zanzibar

Emerging Infectious Diseases, 2020
Artemisinin-based combination therapies (ACTs) are first-line treatments for uncomplicated Plasmodium falciparum malaria. ACT resistance is spreading in Asia but not yet in Africa.
M. Msellem, U. Morris, A. Soe, F. Abbas, Abdul-Wahid Ali, Rory Barnes, P. Frumento, A. Ali, A. Mårtensson, A. Björkman   +9 more
semanticscholar   +1 more source

Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation

Química Nova, 2010
The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA.
Maria Lara P. M. Arguelho, José do Patrocínio H. Alves, Nelson R. Stradiotto, Valdemar Lacerda Júnior, José Maria Pires, Adilson Beatriz   +5 more
doaj   +1 more source