Results 71 to 80 of about 10,947 (204)

The Nuclear Receptor Nurr1 Modulates the Expression and Activity of PPARγ in Human Pro‐Inflammatory Macrophages

Scandinavian Journal of Immunology, Volume 102, Issue 5, November 2025.
Nurr1 activation in human primary macrophages induced the increment of PPARγ expression through protein stabilisation and reduction of the proportion of PPARγ phosphorylated at Ser84, a repressive mark for PPARγ transcriptional activity. The Nurr1 agonist C‐DIM12 enhanced the rosiglitazone‐induced expression of PPARγ‐responsive genes. ABSTRACT Nurr1 is
Eduardo Santana‐Cisneros, Miguel A. Solís‐Barbosa, Norma C. Segovia‐Gamboa, Marco A. Meraz‐Ríos, Erika González‐Domínguez, Rosaura Hernández‐Rivas, Daniel Marrero‐Rodríguez, Carmen Sanchez‐Torres   +7 more
wiley   +1 more source

Efficacy and safety of artemether–lumefantrine, artesunate–amodiaquine, and dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in three provinces in Angola, 2017

Malaria Journal, 2018
The Angolan government recommends three artemisinin-based combinations for the treatment of uncomplicated Plasmodium falciparum malaria: artemether–lumefantrine (AL), artesunate–amodiaquine (ASAQ), and dihydroartemisinin–piperaquine (DP).
Elizabeth A Davlantes, P. R. Dimbu, C. Ferreira, Maria Florinda Joao, D. Pode, Jacinto Félix, Edgar Sanhangala, Benjamin Nieto Andrade, Samaly dos Santos Souza, Eldin Talundzic, V. Udhayakumar, C. Owens, Eliane Mbounga, L. Wiesner, Eric S. Halsey, J. Martins, F. Fortes, M. Pluciński   +17 more
semanticscholar   +1 more source

Translation of a Human‐Based Malaria‐on‐a‐Chip Phenotypic Disease Model for In Vivo Applications

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Inoculation of the Malaria‐on‐a‐Chip model with human erythrocytes infected with Plasmodium falciparum can support the entire intraerythrocytic lifecycle for 7 days in vitro. Utilizing this human‐based, serum‐free model provides an alternative to animal testing by introducing a human‐based, preclinical alternative for antimalarial therapeutic delivery.
Michael J. Rupar, Hannah M. Hanson, Brianna L. Botlick, Narasimhan Sriram, Stephanie Rogers, Justin Zuniga, Zhanhe Liu, Steven J. Trimmer, Joseph M. Ciurca, Christopher J. Long, Christopher W. McAleer, Stephan Schmidt, Paola Favuzza, Philip Lowe, Nathalie Gobeau, James J. Hickman   +15 more
wiley   +1 more source

Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters [version 2; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: The human malaria parasite Plasmodium falciparum has evolved drug evasion mechanisms to all available antimalarials. The combination of amodiaquine-artesunate is among the drug of choice for treatment of uncomplicated malaria.
Loise Ndung'u, Benard Langat, Esther Magiri, Joseph Ng'ang'a, Beatrice Irungu, Alexis Nzila, Daniel Kiboi   +6 more
doaj   +1 more source

A Nurr1 ligand C-DIM12 attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice

Scientific Reports, 2022
We have previously reported that amodiaquine, a compound that binds to the ligand-binding domain of a nuclear receptor Nurr1, attenuates inflammatory responses and neurological deficits after intracerebral hemorrhage (ICH) in mice. 1,1-Bis(3′-indolyl)-1-(
Keita Kinoshita, Ayaka Yoshimizu, Yusei Ichihara, Keisuke Ushida, Shunsuke Kotani, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki   +7 more
doaj   +1 more source

Oligochitosan Conjugates of the Antimalarials Dihydroartemisinin and Lumefantrine: Synthesis, Stability, Cell Viability, and Antiplasmodial Studies

Applied Research, Volume 4, Issue 5, October 2025.
Schematic representation of orally administered antimalarial–oligochitosan conjugates. The mucoadhesive properties of oligochitosan facilitate enhanced drug absorption across the intestinal epithelium (Image created in BioRender.com & Microsoft 365 PowerPoint).
William Matshe, Sindisiwe Mvango, Rudzani Malabi, Asongwe Tantoh, Charlene Andraos, Ibukun Famuyide, Lyndy McGaw, Sooraj Baijnath, Lynne Pilcher, Mohammed Balogun   +9 more
wiley   +1 more source

Amodiaquine

Definitions, 2020
An orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum ...

semanticscholar   +1 more source

Seasonal Malaria Chemoprevention Implementation: Effect on Malaria Incidence and Immunity in a Context of Expansion of P. falciparum Resistant Genotypes with Potential Reduction of the Effectiveness in Sub-Saharan Africa

Infection and Drug Resistance, 2022
Séni Nikiema,1,2 Issiaka Soulama,1,3 Salif Sombié,1 André-Marie Tchouatieu,4 Samuel Sindie Sermé,5 Noëlie Béré Henry,5 Nicolas Ouedraogo,1 Nathalie Ouaré,1,6 Raissa Ily,1,6 Oumarou Ouédraogo,3 Dramane Zongo,3 Florencia Wendkuuni Djigma,2 Alfred B Tiono,1
Nikiema S, Soulama I, Sombié S, Tchouatieu AM, Sermé SS, Henry NB, Ouedraogo N, Ouaré N, Ily R, Ouédraogo O, Zongo D, Djigma FW, Tiono AB, Sirima SB, Simporé J   +14 more
doaj  

Tubular Injury in Diabetic Kidney Disease: Early Diagnosis and Intervention Strategies

Diabetes/Metabolism Research and Reviews, Volume 41, Issue 7, October 2025.
ABSTRACT Diabetic kidney disease (DKD) is the most severe complication of diabetes mellitus and has poor prognosis, often progressing to end‐stage renal disease, causing substantial morbidity and mortality globally. While the pathogenesis of DKD has been extensively characterised, including glomerular hyperfiltration, podocyte injury, and ...
Yi Lv, Chen Ye, Zixi Li, Jiajia Ye, Huanhuan Cao, Chun Zhang, Huajun Jiang, Yumei Wang   +7 more
wiley   +1 more source

Gametocytaemia in senegalese children with uncomplicated Falciparum malaria treated with chloroquine, amodiaquine or sulfadoxine + pyrimethamine

Parasite, 2001
Plasmodium falciparum gametocytaemia was studied in 266 Senegalese children (median 4 years, range 0.5-16) with uncomplicated malaria treated with chloroquine (CQ), amodiaquine (AQ) or sulfadoxine+pyrimethamine (SP).
Sokhina C.S, Trape J.-F, Robert V.
doaj   +1 more source