Results 71 to 80 of about 13,912 (195)

A Nurr1 ligand C-DIM12 attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice

Scientific Reports, 2022
We have previously reported that amodiaquine, a compound that binds to the ligand-binding domain of a nuclear receptor Nurr1, attenuates inflammatory responses and neurological deficits after intracerebral hemorrhage (ICH) in mice. 1,1-Bis(3′-indolyl)-1-(
Keita Kinoshita, Ayaka Yoshimizu, Yusei Ichihara, Keisuke Ushida, Shunsuke Kotani, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki   +7 more
doaj   +1 more source

Artemisinin-based combinations versus amodiaquine plus sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Faladje, Mali [PDF]

, 2009
Background Because of the emergence of chloroquine resistance in Mali, artemether-lumefantrine (AL) or artesunate-amodiaquine (AS+AQ) are recommended as first-line therapy for uncomplicated malaria, but have not been available in Mali until recently ...
Kassoum Kayentao, Hamma Maiga, Robert D Newman, Meredith L McMorrow, Annett Hoppe, Oumar Yattara, Hamidou Traore, Younoussou Kone, Etienne A Guirou, Renion Saye, Boubacar Traore, Abdoulaye Djimde, Ogobara K Doumbo, H Sangho, X De Radigues, World Health Organization and UNICEF, AA Djimdé, I Sagara, CO Obonyo, BJ Bell, MA Thera, K Kayentao, B Faye, FP Mockenhaupt, D Menard, World Health Organization, DA Diallo, N Bakyaita, SG Staedke, CE Rwagacondo, S Krishna, A Yeka   +31 more
core   +2 more sources

IA‐0130, a novel 3‐(1,3‐diarylallylidene)oxindole derivative, alleviates ovarian cancer via inhibiting IL‐6/gp130/STAT3 signalling

British Journal of Pharmacology, Volume 182, Issue 22, Page 5670-5689, November 2025.
Background and Purpose Dysregulation of the IL‐6/glycoprotein 130(gp130)/STAT3 signalling axis is implicated in several human diseases, particularly cancer. Notably, gp130, a single transducer of this signalling axis, is a target for ovarian cancer treatment. However, data regarding small‐molecule inhibitors of gp130 are lacking. Therefore, we aimed to
Sun‐Ae Park, Hee Jung Kim, Lee Kyung Kim, Hae‐Ri Lee, Bo‐Kyung Jung, Ji Hyeon Kim, Myung Jin Kim, Tae Gwon Oh, Hee Eun Kang, Kye Jung Shin, Jae Hong Seo, Tae‐Hwe Heo   +11 more
wiley   +1 more source

Pharmacokinetics and safety profile of artesunate-amodiaquine co-administered with antiretroviral therapy in malaria uninfected HIV-positive Malawian adults. [PDF]

, 2018
There are limited data on the pharmacokinetic and safety profiles of artesunate-amodiaquine in human immnunodeficiency virus infected (HIV+) individuals receiving antiretroviral therapy. In a two-step intensive sampling pharmacokinetic trial, we compared
Banda, Clifford, Dzinjalamala, Fraction, Mukaka, Mavuto, Mallewa, Jane, Maiden, Victor, Terlouw, Anja, Lalloo, David, Khoo, Saye H, Mwapasa, Victor   +8 more
core   +3 more sources

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, Volume 58, Issue 11, November 2025.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity

E-Journal of Chemistry, 2009
Amodiaquine is a 4-aminoquinoline antimalarial that can cause adverse side effects including hepatic and haematological toxicity. The drug toxicity involves the formation of an electrophilic metabolite, amodiaquine quinoneimine (AQQI), which binds to ...
Chandra Nath Saha, Sanjib Bhattacharya, Dipak Chetia   +2 more
doaj   +1 more source

Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type

Malaria Journal, 2010
The loss of chloroquine due to selection and spread of drug resistant Plasmodium falciparum parasites has greatly impacted malaria control, especially in highly endemic areas of Africa.
Twu Olivia, Sa Juliana M
doaj   +1 more source

High Efficacy of Two Artemisinin-Based Combinations (Artesunate + Amodiaquine and Artemether + Lumefantrine) in Caala, Central Angola. [PDF]

, 2006
In April 2004, 137 children 6-59 months of age with uncomplicated Plasmodium falciparum (Pf) malaria (Caala, Central Angola) were randomized to receive either artemether-lumefantrine (Coartem) or artesunate + amodiaquine (ASAQ).
Balkan, S, Cohuet, S, Fortes, F, Francis, M, Guthmann, J P, Kiguli, J, Kyomuhendo, J, Mulemba, M, Noël, F, Rigutto, C, Saraiva, N   +10 more
core   +1 more source

Use of area under the curve to evaluate the effects of antimalarial drugs on malaria associated anemia after treatment [PDF]

, 2011
To evaluate the effects of antimalarial drugs on Plasmodium falciparum malaria associated anemia (MAA), we use the area under curve (AUC) of anemia levels after treatment as an approach to combine their duration and magnitude.
Fatunmbi, Bayo, Folarin, Onikepe A, Gbotosho, Grace O., Happi, Christian T., Michael, Obaro S, Okuboyejo, Titilope M, Sowunmi, Akintunde   +6 more
core   +1 more source

The Nuclear Receptor Nurr1 Modulates the Expression and Activity of PPARγ in Human Pro‐Inflammatory Macrophages

Scandinavian Journal of Immunology, Volume 102, Issue 5, November 2025.
Nurr1 activation in human primary macrophages induced the increment of PPARγ expression through protein stabilisation and reduction of the proportion of PPARγ phosphorylated at Ser84, a repressive mark for PPARγ transcriptional activity. The Nurr1 agonist C‐DIM12 enhanced the rosiglitazone‐induced expression of PPARγ‐responsive genes. ABSTRACT Nurr1 is
Eduardo Santana‐Cisneros, Miguel A. Solís‐Barbosa, Norma C. Segovia‐Gamboa, Marco A. Meraz‐Ríos, Erika González‐Domínguez, Rosaura Hernández‐Rivas, Daniel Marrero‐Rodríguez, Carmen Sanchez‐Torres   +7 more
wiley   +1 more source