Results 71 to 80 of about 15,149 (207)

Micronutrient Powders Combined With Malaria Chemoprevention to Improve Anaemia and Cognitive Function in Early Childhood in Mali: A Cluster‐Randomised Trial

Maternal &Child Nutrition, Volume 21, Issue 4, October 2025.
Globally nearly 40% of children under 5 years old are anaemic, which affects their ability to grow and develop. A cluster randomised trial was conducted in 60 communities in Southern Mali to evaluate the added impact of home fortification with micronutrient powders, delivered alongside seasonal malaria chemoprevention, on anaemia, malaria infection ...
Niélé H. Diarra, Yahia Dicko, Natalie Roschnik, Modibo Bamadio, Michael Boivin, Yvonne Griffiths, Rebecca Jones, Sham Lal, Helen Moestue, Hamidou Niangaly, Lauren Pisani, Renion Saye, Kalifa Sidibe, Karla Smuts, Nia‐An Philippe Thera, Josselin Thuilliez, Hans Verhoef, Moussa Sacko, Siân E. Clarke   +18 more
wiley   +1 more source

Opportunities and Challenges of Population Pharmacogenomics

Annals of Human Genetics, Volume 89, Issue 5, Page 384-397, September 2025.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou, Yoomi Park, Mahamadou D. Camara, Volker M. Lauschke   +3 more
wiley   +1 more source

Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters [version 2; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: The human malaria parasite Plasmodium falciparum has evolved drug evasion mechanisms to all available antimalarials. The combination of amodiaquine-artesunate is among the drug of choice for treatment of uncomplicated malaria.
Loise Ndung'u, Benard Langat, Esther Magiri, Joseph Ng'ang'a, Beatrice Irungu, Alexis Nzila, Daniel Kiboi   +6 more
doaj   +1 more source

A Nurr1 ligand C-DIM12 attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice

Scientific Reports, 2022
We have previously reported that amodiaquine, a compound that binds to the ligand-binding domain of a nuclear receptor Nurr1, attenuates inflammatory responses and neurological deficits after intracerebral hemorrhage (ICH) in mice. 1,1-Bis(3′-indolyl)-1-(
Keita Kinoshita, Ayaka Yoshimizu, Yusei Ichihara, Keisuke Ushida, Shunsuke Kotani, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki   +7 more
doaj   +1 more source

Use of area under the curve to evaluate the effects of antimalarial drugs on malaria associated anemia after treatment [PDF]

, 2011
To evaluate the effects of antimalarial drugs on Plasmodium falciparum malaria associated anemia (MAA), we use the area under curve (AUC) of anemia levels after treatment as an approach to combine their duration and magnitude.
Fatunmbi, Bayo, Folarin, Onikepe A, Gbotosho, Grace O., Happi, Christian T., Michael, Obaro S, Okuboyejo, Titilope M, Sowunmi, Akintunde   +6 more
core   +1 more source

Concentration–Response Analysis of the Combination of Pyronaridine and Piperaquine on Corrected QT Interval From a Randomized, Double‐Blind, Placebo‐Controlled Study in Healthy Adults of African Sub‐Saharan Origin

Clinical and Translational Science, Volume 18, Issue 7, July 2025.
ABSTRACT A novel oral combination of the long‐acting antimalarials pyronaridine (PYR) and piperaquine (PQP) has potential for malaria chemoprevention. This single‐center randomized, double‐blind, placebo‐controlled study assessed the effects of PYR and PQP alone and when co‐administered on Fridericia‐corrected QT interval (QTcF).
Mathieu Felices, Isabelle Borghini‐Fuhrer, Nada Abla, Stephan Chalon   +3 more
wiley   +1 more source

Seasonal Malaria Chemoprevention Implementation: Effect on Malaria Incidence and Immunity in a Context of Expansion of P. falciparum Resistant Genotypes with Potential Reduction of the Effectiveness in Sub-Saharan Africa

Infection and Drug Resistance, 2022
Séni Nikiema,1,2 Issiaka Soulama,1,3 Salif Sombié,1 André-Marie Tchouatieu,4 Samuel Sindie Sermé,5 Noëlie Béré Henry,5 Nicolas Ouedraogo,1 Nathalie Ouaré,1,6 Raissa Ily,1,6 Oumarou Ouédraogo,3 Dramane Zongo,3 Florencia Wendkuuni Djigma,2 Alfred B Tiono,1
Nikiema S, Soulama I, Sombié S, Tchouatieu AM, Sermé SS, Henry NB, Ouedraogo N, Ouaré N, Ily R, Ouédraogo O, Zongo D, Djigma FW, Tiono AB, Sirima SB, Simporé J   +14 more
doaj  

Pharmacokinetics and safety profile of artesunate-amodiaquine co-administered with antiretroviral therapy in malaria uninfected HIV-positive Malawian adults. [PDF]

, 2018
There are limited data on the pharmacokinetic and safety profiles of artesunate-amodiaquine in human immnunodeficiency virus infected (HIV+) individuals receiving antiretroviral therapy. In a two-step intensive sampling pharmacokinetic trial, we compared
Banda, Clifford, Dzinjalamala, Fraction, Mukaka, Mavuto, Mallewa, Jane, Maiden, Victor, Terlouw, Anja, Lalloo, David, Khoo, Saye H, Mwapasa, Victor   +8 more
core   +3 more sources

Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert, Lucie Paloque, Jean‐Michel Augereau, Flore Nardella, Michel Nguyen, Bernard Meunier, Françoise Benoit‐Vical   +6 more
wiley   +1 more source

Gametocytaemia in senegalese children with uncomplicated Falciparum malaria treated with chloroquine, amodiaquine or sulfadoxine + pyrimethamine

Parasite, 2001
Plasmodium falciparum gametocytaemia was studied in 266 Senegalese children (median 4 years, range 0.5-16) with uncomplicated malaria treated with chloroquine (CQ), amodiaquine (AQ) or sulfadoxine+pyrimethamine (SP).
Sokhina C.S, Trape J.-F, Robert V.
doaj   +1 more source