Results 71 to 80 of about 10,579 (201)

Seasonal Malaria Chemoprevention Implementation: Effect on Malaria Incidence and Immunity in a Context of Expansion of P. falciparum Resistant Genotypes with Potential Reduction of the Effectiveness in Sub-Saharan Africa

Infection and Drug Resistance, 2022
Séni Nikiema,1,2 Issiaka Soulama,1,3 Salif Sombié,1 André-Marie Tchouatieu,4 Samuel Sindie Sermé,5 Noëlie Béré Henry,5 Nicolas Ouedraogo,1 Nathalie Ouaré,1,6 Raissa Ily,1,6 Oumarou Ouédraogo,3 Dramane Zongo,3 Florencia Wendkuuni Djigma,2 Alfred B Tiono,1
Nikiema S, Soulama I, Sombié S, Tchouatieu AM, Sermé SS, Henry NB, Ouedraogo N, Ouaré N, Ily R, Ouédraogo O, Zongo D, Djigma FW, Tiono AB, Sirima SB, Simporé J   +14 more
doaj  

Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters [version 2; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: The human malaria parasite Plasmodium falciparum has evolved drug evasion mechanisms to all available antimalarials. The combination of amodiaquine-artesunate is among the drug of choice for treatment of uncomplicated malaria.
Loise Ndung'u, Benard Langat, Esther Magiri, Joseph Ng'ang'a, Beatrice Irungu, Alexis Nzila, Daniel Kiboi   +6 more
doaj   +1 more source

A Nurr1 ligand C-DIM12 attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice

Scientific Reports, 2022
We have previously reported that amodiaquine, a compound that binds to the ligand-binding domain of a nuclear receptor Nurr1, attenuates inflammatory responses and neurological deficits after intracerebral hemorrhage (ICH) in mice. 1,1-Bis(3′-indolyl)-1-(
Keita Kinoshita, Ayaka Yoshimizu, Yusei Ichihara, Keisuke Ushida, Shunsuke Kotani, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki   +7 more
doaj   +1 more source

Neonatal Survival Following Spontaneous Maternal Recovery From Ebola Virus Disease in a Resource‐Limited Setting in Western Democratic Republic of the Congo

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Background: Pregnancy induces physiological decline in maternal immunity. Ebola virus disease (EVD) in pregnancy is associated with obstetrical complications, and vaccination in early pregnancy is recommended, but may not be without risk. Case Presentation: We described neonatal survival after spontaneous maternal EVD recovery. This neonate was born to
Prince Imani-Musimwa, Emilie Grant, Daniel Mukadi-Bamuleka, Rigo Fraterne-Muhayangabo, Richard Kitenge-Omasumbu, Placide Mbala-Kingebeni, Zacharie Tsongo-Kibendelwa, Olivier Nyakio-Ngeleza, Ines Claris-Mwatsi, Juakali Sihali-Kyolov, Théophile Barhwamire-Kabesha, Celine Kavira-Malengera, Micheline Feza-Malira, Richard Bitwe-Mihanda, Dieudonné Sengeyi-Mushengezi-Amani, Mija Ververs, Dawei Cui   +16 more
wiley   +1 more source

Efficacy of artemether–lumefantrine, artesunate–amodiaquine, and dihydroartemisinin–piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in Angola, 2015

Malaria Journal, 2017
Recent anti-malarial resistance monitoring in Angola has shown efficacy of artemether–lumefantrine (AL) in certain sites approaching the key 90% lower limit of efficacy recommended for artemisinin-based combination therapy.
M. Pluciński, P. R. Dimbu, A. Macaia, C. Ferreira, Claudete Samutondo, Joltim Quivinja, Marília Afonso, Richard Kiniffo, Eliane Mbounga, Julia Kelley, Dhruviben Patel, Yun He, Eldin Talundzic, D. Garrett, Eric S. Halsey, V. Udhayakumar, P. Ringwald, F. Fortes   +17 more
semanticscholar   +1 more source

Protecting the malaria drug arsenal: halting the rise and spread of amodiaquine resistance by monitoring the PfCRT SVMNT type

Malaria Journal, 2010
The loss of chloroquine due to selection and spread of drug resistant Plasmodium falciparum parasites has greatly impacted malaria control, especially in highly endemic areas of Africa.
Twu Olivia, Sa Juliana M
doaj   +1 more source

Nanoformulation and Preclinical Evaluation of Dihydroartemisinin–Lumefantrine and Primaquine as Combined Antimalarial Therapy

Journal of Nanotechnology, Volume 2025, Issue 1, 2025.
The World Health Organization recommends artemisinin‐based combinations for uncomplicated malaria treatment. Artemether and lumefantrine (LUM) are the first‐line treatments, with artemether serving as a prodrug of dihydroartemisinin (DHA), while primaquine (PQ) is primarily used as a prophylactic drug.
Pesila Odera, Geoffrey Otieno, Joab Onyango, Bernhards Ogutu, James Owour, Florence Oloo, Martin Ongas, Hulda Swai, Jeremiah Gathirwa, Arnab Biswas   +9 more
wiley   +1 more source

Efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria: revisiting molecular markers in an area of emerging AQ and SP resistance in Mali

Malaria Journal, 2009
Background To update the National Malaria Control Programme of Mali on the efficacy of chloroquine, amodiaquine and sulphadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria.
Wele Mamadou, Dembele Demba, Kone Aminatou, Dama Souleymane, Ouologuem Dinkorma, Fofana Bakary, Sagara Issaka, Maiga Hamma, Beavogui Abdoul H, Djimde Abdoulaye A, Tekete Mamadou, Dicko Alassane, Doumbo Ogobara K   +12 more
doaj   +1 more source

Predicting Clinical Outcomes of SARS‐CoV‐2 Drug Efficacy with a High‐Throughput Human Airway Microphysiological System

Advanced Biology, Volume 8, Issue 11, November 2024.
PREDICT96‐ALI, an in vitro microphysiological model of human lung tissue derived from normal human primary tracheobronchial cells, resolves distinctive replication kinetics of native SARS‐CoV‐2 variants of concern. When used to test a panel of antivirals or prospective antivirals, the platform distinguishes clinically efficacious antiviral therapies ...
Landys Lopez Quezada, Felix Mba Medie, Rebeccah J. Luu, Robert B. Gaibler, Elizabeth P. Gabriel, Logan D. Rubio, Thomas J. Mulhern, Elizabeth E. Marr, Jeffrey T. Borenstein, Christine R. Fisher, Ashley L. Gard   +10 more
wiley   +1 more source

Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing

Antimicrobial Agents and Chemotherapy, 2018
Amodiaquine plus artesunate is the recommended antimalarial treatment in many countries where malaria is endemic. However, pediatric doses are largely based on a linear extrapolation from adult doses.
A. Ali, M. Penny, Thomas A. Smith, L. Workman, P. Sasi, G. Adjei, F. Aweeka, J. Kiechel, V. Jullien, M. Rijken, R. McGready, Julia Mwesigwa, K. Kristensen, K. Stepniewska, J. Tarning, K. Barnes, P. Denti, Achille Adama Adicat Agnés Alphonse Anna Arnaud Aung Pyae Massougbodji Gansané Adeothy Aubouy Ouedraogo Anne   +17 more
semanticscholar   +1 more source