Results 71 to 80 of about 7,380 (205)

Antimalarial Drugs-Induced Hepatic Injury in Rats and the Protective Role of Carnosine

Pharmaceutical Sciences, 2016
Background: Chloroquine and amodiaquine are used in the prophylaxis and treatment of malaria. However, hepatic injury is associated with malaria drug therapy. On the other hand, there is no promising hepatoprotective agent for prophylaxis or treatment of
Akram Jamshidzadeh, Reza Heidari, Farzaneh Abazari, Maral Ramezani, Forouzan Khodaei, Mohammad Mehdi Ommati, Maryam Ayarzadeh, Roya Firuzi, Arastoo Saeedi, Negar Azarpira, Asma Najibi
doaj   +1 more source

The Pharmacogenetics of the Antimalarial Amodiaquine

, 2012
Jose Pedro Gil1,2,3 1Department of Physiology and Pharmacology, Drug Resistance Unit, Division of Pharmacogenetics, Karolinska Institutet, Stockholm, 2Department of Biomedical Sciences, University of Algarve IBB-Institute for Biotechnology and Bioengineering, The Centre for Molecular and Structural Biomedicine, Gambelas, 3Department of Biological ...
openaire   +4 more sources

Preparation and evaluation of mixed-ligand complexes of Cu (II) and Co (II) with amodiaquine hydrochloride and sulphamethazine

Journal of Applied Sciences and Environmental Management, 2018
Cu (ll) and Co (II) complexes of amodiaquine hydrochloride and sulphamethazine (AMOSUF) have been prepared and characterized by elemental analysis, molar conductivity, FTIR and electronic spectroscopy.
E.A. Enemose, E.E. Akporhonor, B Kpomah
doaj   +1 more source

Ex-vivo Sensitivity of Plasmodium falciparum to Common Anti-malarial Drugs: The Case of Kéniéroba, a Malaria Endemic Village in Mali

Drugs in R&D, 2020
Background In 2006, the National Malaria Control Program in Mali recommended artemisinin-based combination therapy as the first-line treatment for uncomplicated malaria.
Karim Traoré, Seidina A. S. Diakité, Sekou Bah, Drissa S. Konaté, Djeneba Dabitao, Ibrahim Sanogo, Modibo Sangaré, Souleymane Dama, Bourama Keita, Mory Doumbouya, Merepen A. Guindo, Seydou Doumbia, Mahamadou Diakité   +12 more
doaj   +1 more source

Recent applications of pharmacometrics and systems pharmacology approaches to improve and optimize drug therapy for pregnant and lactating women

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 11, Page 1815-1819, November 2024.
Priya Jayachandran, Jane Knöchel, Brian Cicali, Karen Rowland Yeo   +3 more
wiley   +1 more source

Selection of pfmdr1 mutations after amodiaquine monotherapy and amodiaquine plus artemisinin combination therapy in East Africa

Infection, Genetics and Evolution, 2007
Despite the pharmacodynamic advantages with artemisinin-based combination therapy (ACT) and some potentially opposite molecular mechanisms of tolerance to amodiaquine (AQ)/desethylamodiaquine (DEAQ) and artesunate (ART), there is a risk for rapid decay in efficacy if the two drugs are unable to ensure mutual prevention against a selection and spread of
Gabrielle Holmgren, Johan Hamrin, José Pedro Gil, José Pedro Gil, Anders Björkman, Andreas Mårtensson, Jenny Svärd   +6 more
openaire   +3 more sources

EFFECT OF AMODIAQUINE ON GASTRIC HISTAMINE METHYLTRANSFERASE AND ON HISTAMINE‐STIMULATED GASTRIC SECRETION [PDF]

, 1975
H. Barth, W. Lorenz, H. Troidl
openalex   +1 more source

Systematic review of amodiaquine treatment in uncomplicated malaria

The Lancet, 1996
Opinion and policy over the use of amodiaquine for treating malaria vary. Amodiaquine is more palatable than chloroquine and may be more effective but serious adverse events have been reported in travellers taking it as prophylaxis. It is not recommended as first-line treatment.
Olliaro P., Nevill, C., Le Bras, J., Ringwald, Pascal, Mussano, P., Garner, P., Brasseur, P.   +6 more
openaire   +4 more sources

Efficacy of amodiaquine in the treatment of uncomplicated falciparum malaria in young children of rural north-western Burkina Faso

Malaria Journal, 2008
Background Combination therapy has become a new paradigm in malaria treatment. Amodiaquine is a common partner drug in different malaria combination therapies used or investigated in sub-Saharan Africa, but data on its efficacy as a single drug are ...
Meissner Peter, Coulibaly Boubacar, Mockenhaupt Frank P, Mandi Germain, Müller Olaf   +4 more
doaj   +1 more source

Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component [PDF]

, 1996
Shaun R. Hawley, P. G. Bray, Paul M. O’Neill, Dean J. Naisbitt, B K Park, Stephen A. Ward   +5 more
openalex   +1 more source