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Delivery of Poorly Soluble Compounds by Amorphous Solid Dispersions
Current Pharmaceutical Design, 2014Solid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in this area, with focus on the fundamentals, characterization, formulation development and ...
Chow, Albert H.L. +5 more
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Diffusivity of amorphous drug in solid dispersion
Journal of Thermal Analysis and Calorimetry, 2013Filmy solid dispersion of terfenadine (TFD), fenofibrate (FFB), and carbamazepine (CBZ) and methacrylic acid methyl methacrylate copolymer (Eudragit®) was prepared by evaporating their solution. Raman and IR measurements for the filmy samples were performed.
Etsuo Yonemochi +3 more
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Dissolution Mechanisms of Amorphous Solid Dispersions
2023The dissolved concentration of an active pharmaceutical ingredient in biological fluids is of significant importance for establishing a therapeutic effect in patients. However, the current pharmaceutical landscape is abundant in poorly soluble drugs that require solubility enhancing techniques to enable their administration. A promising technique, with
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Characterization of amorphous solid dispersions: An update
Journal of Drug Delivery Science and Technology, 2019Abstract Amorphous solid dispersions (ASDs) are a promising formulation approach to improve the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have complicated physicochemical properties due to the various formulations and processes used to produce them. These properties influence their physical stability, so it
Xiangyu Ma, Robert O. Williams
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Structural Characterization of Amorphous Solid Dispersions
2014Amorphous solid dispersions (ASD) stand on the forefront of solubilizing formulations for many poorly soluble drug candidates. It has been widely accepted that the physical stability, downstream processability, and performance of an ASD largely inherits its physical structure. The in-depth and multi-methodological characterization of ASD microstructure
Amrit Paudel +2 more
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Release Mechanisms of Amorphous Solid Dispersions
2022As the pharmaceutical industry moves towards molecular obesity with the use of high throughput screening for identification of promising candidates, the low aqueous solubilities of new chemical entities pose significant challenges to achieving adequate oral absorption and bioavailability. Enabling formulations are often needed to address this issue.
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Overview of Amorphous Solid Dispersion Technologies
2014Successful development of amorphous solid dispersion formulations depends on three primary factors: active pharmaceutical ingredient properties, stabilizing polymer, and the processing technology. Polymer provides the fundamental framework for stabilizing the amorphous form and the process supplies the energy required to transform the system into an ...
Harpreet Sandhu +3 more
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Ternary Amorphous Solid Dispersions
Journal of Developing Drugs, 2017Dev Prasad +3 more
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Polymeric solid dispersion Vs co-amorphous technology: A critical comparison
Journal of Drug Delivery Science and Technology, 2022Athira R Nair +2 more
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