Results 171 to 180 of about 106,566 (335)

Cyclic AMP and synaptic activity-dependent phosphorylation of AMPA- preferring glutamate receptors [PDF]

, 1994
Craig Blackstone, Timothy H. Murphy, S.J. Moss, Jay M. Baraban, RL Huganir   +4 more
openalex   +1 more source

Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgenic mice

Neuroprotection, EarlyView.
Downregulation of the expression of silent information regulator sirtuin 1 (SIRT1) exacerbates neuronal degeneration and loss by activating forkhead box O1 (FOXO1) acetylation and promoting endoplasmic reticulum stress (ERSA)‐mediated apoptosis in aging.
Nan Zhang, Zongyuan Zhao, Xiaoxiao Chen, Hanbing Yao, Min Zhu, Shuqing Ma, Hui Wang, Xianghong Yin, Ying Zhou, Chenfei Zheng, Jianmin Li, Jingye Pan, Kaicheng Wang, Bin Yang, Yunting Wang, Junming Fan, Yongsheng Gong, Rong Liu, Jing Zeng, Xiaofang Fan, Yangping Shentu   +20 more
wiley   +1 more source

Vesicular glutamatergic transmission in noise-induced loss and repair of cochlear ribbon synapses [PDF]

, 2019
Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic mechanisms are unknown, and the necessity of glutamate for synapse loss or regeneration is unclear. Despite absence of glutamatergic transmission from cochlear inner
Carlquist, Jason, Davis, Bethany, Fitzpatrick, James A.J., Gantz, Jay A, Hirose, Keiko, Kallogjeri, Dorina, Kim, Kyunghee X, Li, Song-Zhe, Ohlemiller, Kevin K, Payne, Shelby, Rutherford, Mark A, V-Ghaffari, Babak, Yang-Hood, Aizhen   +12 more
core   +1 more source

Cyclothiazide unmasks AMPA‐evoked stimulation of [³H]‐L‐glutamate release from rat hippocampal synaptosomes [PDF]

, 1994
Janine M. Barnes, Kumlesh K. Dev, Jeremy M. Henley   +2 more
openalex   +1 more source

A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord [PDF]

, 1994
Boris A. Chizh, M. Cumberbatch, P.M. Headley   +2 more
openalex   +1 more source

Elucidating the Three‐Dimensional Structure of Piracetam through Rotational Spectroscopy

ChemistryOpen, EarlyView.
Neutral molecules of the nootropic drug piracetam are generated by laser ablation and structurally characterized by microwave spectroscopy. Two conformers differing in the exo/endo configuration of the pyrrolidine ring are detected, with exo being the predominant form.
S. Mato, S. Municio, J. L. Alonso, E. R. Alonso, I. León   +4 more
wiley   +1 more source

Improving screening model of pesticide risk assessment in surface soils: Considering degradation metabolites

Ecotoxicology and Environmental Safety, 2021
As pesticides can be degraded to toxic metabolites in the soil, metabolite toxicity should be considered in human health risk assessments. In this study, a screening-level modeling framework was developed to manage pesticides in surface soil, which was ...
Zijian Li
doaj  

Effectiveness and safety of perampanel for pediatric patients with epilepsy: A real‐world study from China

Pediatric Investigation, EarlyView.
The 50% responder rate and seizure freedom rate after 6 months of PER treatment during routine clinical care were 70.4% and 22.1%, respectively. The 50% responder rates for the 3 age‐based cohorts were 64.5% in infants and young children, 73.4% in children and 69.2% in adolescents, and the Seizure‐freedom rates were 16.1%, 23.7% and 25.6% respectively.
Xiaohui Wang, Taoyun Ji, Maomao Liu, Xiaofei Wang, Zhixian Yang, Sanmei Wang, Liping Zou, Jiong Qin, Xiaotun Ren, Liankun Ren, Liri Jin, Jie Shi, Dantao Peng, Kui Chen, Jindong Dai, Nan Zhang, Jun Wang, Tianyu Song, Fang Fang, Yuehua Zhang, Qun Wang   +20 more
wiley   +1 more source

Metabotropic Glutamate Receptor Activation in Cerebelar Purkinje Cells as Substrate for Adaptive Timing of the Classicaly Conditioned Eye Blink Response [PDF]

, 1995
To understand how the cerebellum adaptively times the classically conditioned nictitating membrane response (NMR), a model of the metabotropic glutamate receptor (mGluR) second messenger system in cerebellar Purkinje cells is constructed.
Bullock, Daniel, Fiala, John C., Grossberg, Stephen   +2 more
core   +1 more source

Persistent phosphorylation parallels long-term desensitization of cerebellar purkinje cell AMPA-type glutamate receptors. [PDF]

, 1997
Kazu Nakazawa, Sumiko Mikawa, M. Ito
openalex   +1 more source