Results 71 to 80 of about 2,334,241 (398)

Clathrin-Independent Trafficking of AMPA Receptors [PDF]

The Journal of Neuroscience, 2015
Membrane trafficking of AMPA receptors (AMPARs) is critical for neuronal function and plasticity. Although rapid forms of AMPAR internalization during long-term depression (LTD) require clathrin and dynamin, the mechanisms governing constitutive AMPAR turnover and internalization of AMPARs during slow homeostatic forms of synaptic plasticity remain ...
Glebov, Oleg, Tigaret, Cezar M., Mellor, Jack R., Henley, Jeremy M.   +3 more
openaire   +4 more sources

Characterization of Phosphorylation Sites on the Glutamate Receptor 4 Subunit of the AMPA Receptors [PDF]

, 1999
Recent studies have suggested that protein phosphorylation of glutamate receptors may play an important role in synaptic transmission. Specifically, the phosphorylation of AMPA receptors has been implicated in cellular models of synaptic plasticity.
Carvalho, Ana Luísa, Huganir, Richard L., Kameyama, Kimihiko   +2 more
core   +1 more source

Mechanisms of AMPA Receptor Endosomal Sorting [PDF]

Frontiers in Molecular Neuroscience, 2018
The regulation of synaptic AMPA receptors (AMPARs) is critical for excitatory synaptic transmission, synaptic plasticity and the consequent formation of neural circuits during brain development and their modification during learning and memory processes.
Parkinson, Gabrielle T., Hanley, Jonathan G.   +1 more
openaire   +6 more sources

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]

, 2010
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A., Jamieson, Craig, Maclean, John K. F., Morrow, John A., Rankovic, Zoran   +4 more
core   +1 more source

Essential roles of AMPA receptor GluA1 phosphorylation and presynaptic HCN channels in fast-acting antidepressant responses of ketamine

Science Signaling, 2016
Ketamine alters presynaptic channels in the hippocampus to mediate fast-acting antidepressant action. Keys to the rapid antidepressant action of ketamine Ketamine is a clinically used “dissociative analgesic” for pain management and a rapidly acting ...
Ke Zhang, Ting Xu, Zhongmin Yuan, Zhisheng Wei, V. Yamaki, Mingfa Huang, R. Huganir, Xiang Cai   +7 more
semanticscholar   +1 more source

Superactivation of AMPA receptors by auxiliary proteins [PDF]

Nature Communications, 2016
AbstractGlutamate receptors form complexes in the brain with auxiliary proteins, which control their activity during fast synaptic transmission through a seemingly bewildering array of effects. Here we devise a way to isolate the activation of complexes using polyamines, which enables us to show that transmembrane AMPA receptor regulatory proteins ...
Andrew J.R. Plested, Andrew J.R. Plested, Anna L. Carbone   +2 more
openaire   +4 more sources

Degradation of Glyphosate to Benign N‐Formyl Glycine Using MOF‐808 Nanocrystals

Angewandte Chemie, EarlyView.
A Zr‐based metal–organic framework (MOF‐808) with different crystal sizes and designed defect sites was employed as an efficient heterogeneous catalyst for the complete degradation of glyphosate at room temperature. The degradation mechanism produces N‐formyl glycine and hydroxymethyl‐phosphonate. Abstract Glyphosate (N‐phosphonomethyl glycine, GPh) is
Jhair A. Peña Prada, Tatiana A. Huertas Navarro, Stephange L. Chua, Alejandro M. Granados, Chih‐Wen Pao, Alejandro M. Fracaroli, Nicholas M. Bedford   +6 more
wiley   +2 more sources

Exploiting the molecular diversity of the synapse to investigate neuronal communication: A guide through the current toolkit

European Journal of Neuroscience, Volume 56, Issue 12, Page 6141-6161, December 2022., 2022
Chemical synapses are tiny and overcrowded environments enriched with thousands of protein species. Many efforts have been devoted to developing sensors and actuators able to evaluate and control synaptic communication. Most of these recent tools are based on the engineering of one or more specific synaptic proteins used to target active moieties to ...
Jacopo Lamanna, Mattia Ferro, Sara Spadini, Antonio Malgaroli   +3 more
wiley   +1 more source

p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression

Nature Communications, 2019
AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA ...
Yuan Ge, Meng Tian, Lidong Liu, Tak Pan Wong, Bo Gong, Dongchuan Wu, Taesup Cho, Shujun Lin, Jürgen Kast, Jie Lu, Yu Tian Wang   +10 more
doaj   +1 more source

How feedback inhibition shapes spike-timing-dependent plasticity and its implications for recent Schizophrenia models [PDF]

, 2011
It has been shown that plasticity is not a fixed property but, in fact, changes depending on the location of the synapse on the neuron and/or changes of biophysical parameters.
Aihara, Akbarian, Andreasen, Angulo, Beasley, Bernd Porr, Bi, Bower, Christoph Kolodziejski, Clopath, De Schutter, De Schutter, Egerton, Feinberg, Florentin Wörgötter, Freund, Guidotti, Hebb, Iglesias, Jolivet, Kehrer, Klopf, Koch, Lewis, Lindskog, Lisman, Lynsey McCabe, Magee, Markram, Morris, O’Mann, Paolo di Prodi, Paz, Pierri, Porr, Porr, Ragland, Rapoport, Rubin, Saudargiene, Shinoda, Somogyi, Straub, Tamosiunaite, Tamosiunaite, Tamosiunaite, Traub, Ulrich, Voegtlin, Yang, Zaitsev   +50 more
core   +1 more source