Results 71 to 80 of about 99,629 (284)

Mitochondrial superoxide production and MnSOD activity following exposure to an agonist and antagonists of ionotropic receptors in rat brain [PDF]

Archives of Biological Sciences, 2005
The involvement of NMDA and AMPA/kainate receptors in the induction of superoxide production in the rat brain was examined after intrahippocampal injection of kainate, a non-NMDA receptor agonist; kainate plus CNQX, a selective AMPA/kainate receptor ...
Radenović Lidija Lj., Selaković Vesna
doaj   +1 more source

Heroin-piracetam mixture: suggested mechanisms of action and risks of misinterpretation for drug users [PDF]

, 2017
Piracetam is a positive allosteric modulator of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor that has been frequently used in the treatment of cognitive disorders.
Cappelletti, Simone, Ciallella, Costantino, Lombardo, Francesco, Vallone, Giuseppe, Vitale, Pasquale   +4 more
core   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

PhotonSABER: new tool shedding light on endocytosis and learning mechanisms in vivo

Communicative & Integrative Biology, 2019
In the central nervous system, activity-dependent endocytosis of postsynaptic AMPA-type glutamate receptors (AMPA receptors) is thought to mediate long-term depression (LTD), which is a synaptic plasticity model in various neuronal circuits.
Shinji Matsuda, Wataru Kakegawa, Michisuke Yuzaki   +2 more
doaj   +1 more source

Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine

The Journal of Headache and Pain, 2022
Background The pathogenesis of chronic migraine remains unresolved. Recent studies have affirmed the contribution of GLUA1-containing AMPA receptors to chronic migraine.
Wei Zhang, Ming Lei, Qianwen Wen, Dunke Zhang, Guangcheng Qin, Jiying Zhou, Lixue Chen   +6 more
doaj   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, EarlyView.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

Acid-Sensing Ion Channels Activated by Evoked Released Protons Modulate Synaptic Transmission at the Mouse Calyx of Held Synapse [PDF]

, 2017
Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. We found that these channels can be activated in neurons of the medial nucleus of the trapezoid body (MNTB) of the auditory system in ...
Di Guilmi, Mariano Nicolás, González Inchauspe, Carlota María Fabiola, Uchitel, Osvaldo Daniel, Urbano Suarez, Francisco Jose   +3 more
core   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Involvement of hippocampal AMPA glutamate receptor changes and the cAMP/protein kinase A/CREB-P signalling pathway in memory consolidation of an avoidance task in rats

Brazilian Journal of Medical and Biological Research, 1997
Training in step-down inhibitory avoidance (0.3-mA footshock) is followed by biochemical changes in rat hippocampus that strongly suggest an involvement of quantitative changes in glutamate AMPA receptors, followed by changes in the dopamine D1 receptor ...
R. Bernabeu, M. Cammarota, I. Izquierdo, J.H. Medina   +3 more
doaj   +1 more source

Assessing the Nature of Human Brain‐Derived Extracellular Vesicles on Synaptic Activity Via the Development of an Air‐liquid Microfluidic Platform

Advanced Science, EarlyView.
This seminal study highlights the interwoven and tightly regulated functions of brain‐derived extracellular vesicles. Using microfluidics, proteomics, and AI‐based electric signal analyses of cortical brain explants, this work provides a useful resource dataset revealing the composition of human brain‐derived extracellular vesicles obtained from ...
Corentin Bernou, Yukiko Iwasaki, Willy Lutz, Glaucia Almeida, Emilie Béchard, François Delalande, Magali Rompais, Jules Bouget, Barbara Gorda, Chantal Cazevieille, Yonis Bare, Christine Carapito, Sophie Colomb, Gowrishankar Ganesh, Raphael Gaudin   +14 more
wiley   +1 more source