Results 191 to 200 of about 48,317 (239)

AMPA receptors play an important role in the biological consequences of spinal cord injury: Implications for AMPA receptor modulators for therapeutic benefit. [PDF]

Biochem Pharmacol
Witkin JM, Radin DP, Rana S, Fuller DD, Fusco AF, Demers JC, Pradeep Thakre P, Smith JL, Lippa A, Cerne R.   +9 more
europepmc   +1 more source

AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking [PDF]

Cellular and Molecular Life Sciences, 2019
To correctly transfer information, neuronal networks need to continuously adjust their synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of their function and is, thus, tightly regulated. In glutamatergic neurons, synaptic strength is controlled by the number and function of AMPA receptors at the ...
Diane Bissen, , Acker-Palmer Amparo
exaly   +4 more sources

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AMPA Receptor Antagonists

Current Medicinal Chemistry, 2001
AMPA Receptor antagonists have received considerable attention in recent years. Within the class of excitatory amino acid receptor antagonists AMPA receptor antagonists have shown excellent neuroprotection in several models of cerebral ischemia and neuronal injury.
S S, Nikam, B E, Kornberg
openaire   +2 more sources

Competitive AMPA Receptor Antagonists

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
CATARZI, DANIELA, COLOTTA, VITTORIA, VARANO, FLAVIA   +2 more
openaire   +3 more sources

RNA aptamers for AMPA receptors

Neuropharmacology, 2021
RNA aptamers are single-stranded RNA molecules, and they are selected against a target of interest so that they can bind to and modulate the activity of the target, such as inhibiting the target activity, with high potency and selectivity. Antagonists, such as RNA aptamers, acting on AMPA receptors, a major subtype of ionotropic glutamate receptors ...
Zhen Huang, Li Niu
openaire   +2 more sources

Neuropharmacology of AMPA and kainate receptors

Neuropharmacology, 1998
David Lodge, David Bleakman, D Bleakman   +2 more
exaly   +3 more sources

Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins

Neuroscience, 2009
The AMPA receptors are ligand-gated ion channels belonging to the family of ionotropic glutamate receptors. They play an essential role in fast excitatory synaptic transmission in the CNS of vertebrates. Their activity-dependent directed transport and fast turnover at the plasma membrane contribute to synaptic plasticity and require numerous ...
C, Sager, D, Tapken, S, Kott, M, Hollmann   +3 more
openaire   +2 more sources

AMPA receptors

Neurology, 2016
In this and forthcoming reviews, a representative clinical case will serve as an introduction to the topic to be discussed. This will provide the basis to address some recent insights from basic neuroscience research on the normal function of the primary target of the disease process involved in the case presented, as well as putative pathophysiologic ...
openaire   +2 more sources

Inhibitors of AMPA and Kainate Receptors

Current Medicinal Chemistry, 2001
The glutamate receptor system is implicated in the development and maintenance of epileptic seizures, and animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of AMPA and/or kainate (KA) receptor activity. These results make such inhibitors potential future antiepileptic drugs.
U, Madsen, T B, Stensbøl, P, Krogsgaard-Larsen   +2 more
openaire   +2 more sources