Results 171 to 180 of about 86,925 (261)

The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse. [PDF]

, 2007
Erazo Fischer, E.
core   +1 more source

Unveiling the Molecular Mechanism of Intestinal Metabolite para‐Cresol in Modulating Neuroinflammation and Synaptic Dysfunction: Implications for Autism Spectrum Disorder

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Here we investigated the effect of p‐Cresol on different brain‐cell types to speculate on their specific contribution to autism spectrum disorder (ASD) synaptic dysfunctions. Our in vitro data show that p‐Cresol impairs dendritic arborization and length, disrupts the excitatory/inhibitory balance, and induces glial activation and inflammatory responses.
Wenjie Liao, Kristy Antonioni, Federica Silvestri, Monica Piemontese, Martina Bodria, Eleonora Daini, Antonio M. Persico, Michele Zoli, Andreas M. Grabrucker, Antonietta Vilella   +9 more
wiley   +1 more source

Systemic increase of AMPA receptors associated with cognitive impairment of long COVID. [PDF]

Brain Commun
Fujimoto Y, Abe H, Eiro T, Tsugawa S, Tanaka M, Hatano M, Nakajima W, Ichijo S, Arisawa T, Takada Y, Kimura K, Sano A, Hirahata K, Sasaki N, Kimura Y, Takahashi T.   +15 more
europepmc   +1 more source

Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome. [PDF]

Front Mol Neurosci, 2023
Chojnacka M, Beroun A, Magnowska M, Stawikowska A, Cysewski D, Milek J, Dziembowska M, Kuzniewska B.   +7 more
europepmc   +1 more source

N,N‐Dimethyltryptamine (DMT) Acutely Exposed to Mouse Ventral Tegmental Area Ih‐Negative Neurons Alters the Firing Rate and Conductance in a Sex‐Dependent Manner

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Depression and substance use disorder are difficult to treat, prompting interest in psychedelics like DMT, though its neural mechanisms remain unclear. This ex vivo study examined acute DMT effects on electrophysiology in male and female Ih‐negative neurons of the mouse ventral tegmental area (VTA). Low‐dose DMT (500 nM) had no effect, whereas a higher
Jannik Nicklas Eliasen, Amir Rezagholizadeh, Helene Påbøl Jacobsen, Kristi A. Kohlmeier   +3 more
wiley   +1 more source

Accumbal calcium-permeable AMPA receptors orchestrate neuronal ensembles underlying social attachment. [PDF]

Nat Commun
El-Kalliny MM, Kushner JK, Sheeran WM, Neilly OE, Winther KE, Brusman LE, Kelberman MA, Hoeffer CA, Donaldson ZR.   +8 more
europepmc   +1 more source

Calcium-permeable AMPA receptors: an underestimated pharmacological target for the therapy of brain pathologies. [PDF]

Neural Regen Res, 2023
Gaidin SG, Kosenkov AM.
europepmc   +1 more source

The development of positron emission tomography (PET) tracer for glutamate AMPA receptors and its application to human biology and clinics

Psychiatry and Clinical Neurosciences, Volume 80, Issue 5, Page 367-373, May 2026.
Psychiatric and neurological disorders severely compromised patients' quality of life. Despite their urgent needs, the development of diagnostics and therapeutics based on the biological basis has made only little progress. This is due to limited evidence on the biological basis of these disorders in humans. Synapses are fundamental structural units of
Mai Hatano, Hiroki Abe, Takuya Takahashi
wiley   +1 more source

Modeling the use of transient ligand binding information by AMPA receptors. [PDF]

NPJ Syst Biol Appl
Braunstein H, Ventura AC, Colman-Lerner A.   +2 more
europepmc   +1 more source

Thiazole Derivatives as Modulators of GluA2 AMPA Receptors: Potent Allosteric Effects and Neuroprotective Potential. [PDF]

Biomolecules, 2023
Hawash M.
europepmc   +1 more source