Results 151 to 160 of about 55,529 (250)
The role of postsynaptic AMPA receptors in stabilizing presynaptic inputs [PDF]
The establishment of functional neuronal circuits relies on the formation of excess synapses, followed by the elimination of inappropriate connections.
Ripley, Beth Ann
core
Psilocybin as a novel treatment for chronic pain
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey +3 more
wiley +1 more source
AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues
The learning processes underlying the formation of drug-cue associations involve changes in synaptic transmission mediated by AMPA receptors. Here, we examine the consequences of targeted deletion of the gene encoding GluR1 subunits of AMPA receptors ...
Andy N Mead (16053851) +3 more
core
Psychedelics, entactogens and psychoplastogens for depression and related disorders
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley +1 more source
Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs [PDF]
Ashby, MC +5 more
core +1 more source
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller +3 more
wiley +1 more source
Neuronal chloride homeostasis, governed by KCC2 and NKCC1 cotransporters, constrains convergence to learning in biophysical spiking neural networks. Systematic exploration of transporter activity shows that successful learning emerges only within a restricted parameter regime, whose boundaries and convergence properties critically depend on NKCC1 ...
Mohamed Ahmed +3 more
wiley +1 more source
Migraine pathophysiology is thought to involve activation of the trigeminal fibres which innervate dural structures. The nociceptive inflow from the meninges is relayed to the trigeminocervical complex (TCC), before ascending to higher brain areas ...
Andreou, A.
core
Impact of Voluntary Alcohol Consumption on Corticostriatal Plasticity in Rats
After 8 weeks voluntary alcohol consumption, AMPA/NMDA ratios were reduced in medium spiny neurons in the dorsolateral striatum, upon optogenetic stimulation of sensorimotor cortical inputs. Moreover, coefficient of variance was reduced and paired‐pulse facilitation was enhanced, selectively in high alcohol drinking rats.
Johanna A. S. Smeets +6 more
wiley +1 more source
Trafficking and ethanol-induced inhibition of AMPA receptors
AMPA receptors are an important class of ionotropic glutamate receptors which participate in fast excitatory synaptic transmission in most brain areas. They have a pivotal role in adjustment of cell membrane excitability as their cell membrane expression
Möykkynen, Tommi
core

