Results 41 to 50 of about 2,293,512 (363)

Subunit-specific role for the amino-terminal domain of AMPA receptors in synaptic targeting

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance It is generally accepted that trafficking of AMPA receptors underlies synaptic enhancement during long-term potentiation, a cellular model for learning and memory.
J. Díaz-Alonso, Y. Sun, Adam J. Granger, Jonathan M. Levy, Sabine M. Blankenship, R. Nicoll   +5 more
semanticscholar   +1 more source

Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum

Neuroscience, 2009
Heterogeneity among AMPA receptor (AMPAR) subtypes is thought to be one of the key postsynaptic factors giving rise to diversity in excitatory synaptic signaling in the CNS. Recently, compelling evidence has emerged that ancillary AMPAR subunits-the so-called transmembrane AMPA receptor regulatory proteins (TARPs)-also play a vital role in influencing ...
Ian D. Coombs, Stuart G. Cull-Candy
openaire   +3 more sources

Intracerebroventricular administration of oxytocin and intranasal administration of the oxytocin derivative improve β‐amyloid peptide (25–35)‐induced memory impairment in mice

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 492-501, December 2022., 2022
Abstract Aim We previously reported that oxytocin, a peptide hormone, can reverse the β‐amyloid peptide (25–35) (Aβ25–35)‐induced impairments of the murine hippocampal synaptic plasticity. In this study, we examined the effects of oxytocin on the Aβ25–35‐induced impairment of cognitive behavior in murine in order to investigate the potential of ...
Junpei Takahashi, Yudai Ueta, Daisuke Yamada, Sachie Sasaki‐Hamada, Takashi Iwai, Tomomi Akita, Chikamasa Yamashita, Akiyoshi Saitoh, Jun‐Ichiro Oka   +8 more
wiley   +1 more source

Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors.

PLoS ONE, 2017
S 47445 is a novel positive allosteric modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors (AMPA-PAM). S 47445 enhanced glutamate's action at AMPA receptors on human and rat receptors and was inactive at NMDA and ...
Sylvie Bretin, Caroline Louis, Laure Seguin, Stéphanie Wagner, Jean-Yves Thomas, Sylvie Challal, Nathalie Rogez, Karine Albinet, Fabrice Iop, Nadège Villain, Sonia Bertrand, Ali Krazem, Daniel Bérachochéa, Stéphanie Billiald, Charles Tordjman, Alex Cordi, Daniel Bertrand, Pierre Lestage, Laurence Danober   +18 more
doaj   +1 more source

P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals

The Journal of Headache and Pain, 2020
Background Purine receptors play roles in peripheral and central sensitization and are associated with migraine headache. We investigated the possibility that ATP plays a permissive role in the activation of AMPA receptors thus inducing Glu release from ...
Diego Currò, Pierluigi Navarra, Irene Samengo, Maria Martire   +3 more
doaj   +1 more source

Analytical modelling of temperature effects on synapses [PDF]

Kufel, D. S., & Wojcik, G. M. (2018). Analytical modelling of temperature effects on an AMPA-type synapse. Journal of computational neuroscience, 44(3), 379-391, 2016
It was previously reported, that temperature may significantly influence neural dynamics on different levels of brain modelling. Due to this fact, while creating the model in computational neuroscience we would like to make it scalable for wide-range of various brain temperatures. However currently, because of a lack of experimental data and an absence
arxiv   +1 more source

Auxiliary subunits keep AMPA receptors compact during activation and desensitization

eLife, 2018
Signal transduction at vertebrate excitatory synapses involves the rapid activation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, glutamate-gated ion channels whose four subunits assemble as a dimer-of-dimers.
Jelena Baranovic, Andrew JR Plested
doaj   +1 more source

Ion channel gradients in the apical tuft region of CA1 pyramidal neurons. [PDF]

PLoS ONE, 2012
Dendritic ion channels play a critical role in shaping synaptic input and are fundamentally important for synaptic integration and plasticity. In the hippocampal region CA1, somato-dendritic gradients of AMPA receptors and the hyperpolarization-activated
Katie C Bittner, Bertalan K Andrasfalvy, Jeffrey C Magee   +2 more
doaj   +1 more source

Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

Nature Communications, 2016
Trafficking and biophysical properties of AMPA receptors (AMPARs) in the brain depend on interactions with associated proteins. We identify Shisa6, a single transmembrane protein, as a stable and directly interacting bona fide AMPAR auxiliary subunit ...
R. Klaassen, J. Stroeder, F. Coussen, Anne-Sophie Hafner, J. Petersen, Cedric Renancio, L. J. Schmitz, E. Normand, J. C. Lodder, D. Rotaru, Priyanka Rao-Ruiz, S. Spijker, H. Mansvelder, D. Choquet, A. Smit   +14 more
semanticscholar   +1 more source

Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-containing NMDA Receptors

Frontiers in Molecular Neuroscience, 2016
NMDA receptors are Ca2+-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function.
Li-Jun Li, Rong Hu, Rong Hu, Brendan Lujan, Juan Chen, Jian-Jian Zhang, Yasuko Nakano, Tian-Yuan Cui, Ming-Xia Liao, Jin-Cao Chen, Hengye Man, Hua Feng, Qi Wan, Qi Wan, Qi Wan, Qi Wan   +15 more
doaj   +1 more source